beta Catenin

A multi-functional catenin that participates in CELL ADHESION and nuclear signaling. Beta catenin binds CADHERINS and helps link their cytoplasmic tails to the ACTIN in the CYTOSKELETON via ALPHA CATENIN. It also serves as a transcriptional co-activator and downstream component of WNT PROTEIN-mediated SIGNAL TRANSDUCTION PATHWAYS.

Also Known As:

Networked: 4231 relevant articles (49 outcomes, 580 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Clevers, Hans: 24 articles (03/2010 - 02/2002)
2.	Brabletz, Thomas: 22 articles (03/2015 - 06/2002)
3.	Moon, Randall T: 22 articles (09/2010 - 02/2003)
4.	Taketo, Makoto M: 21 articles (09/2010 - 01/2002)
5.	Fearon, Eric R: 21 articles (05/2010 - 03/2002)
6.	Nosho, Katsuhiko: 20 articles (04/2011 - 09/2006)
7.	Hirohashi, Setsuo: 20 articles (09/2009 - 04/2002)
8.	Ogino, Shuji: 17 articles (04/2011 - 07/2007)
9.	Tanaka, Takuji: 17 articles (07/2010 - 09/2002)
10.	Ben-Ze'ev, Avri: 17 articles (06/2010 - 07/2002)

Related Diseases

1.	Neoplasms (Cancer) 12/01/2008 - "Immunohistochemical analysis demonstrated significantly greater beta-catenin accumulation in pyloric tumors, compared with those in the fundus (P < 0.01) with mutations of exon 3; 18.2% and 31.6% in MNU-alone and MNU + H. " 10/15/2006 - "Effective treatment of tumors with strong beta-catenin/T-cell factor activity by transcriptionally targeted oncolytic herpes simplex virus vector." 12/01/2005 - "RT-PCR analysis successfully confirmed the presence of both beta-catenin splice variants in histologically normal and preneoplastic squamous epithelium, and invasive tumors of the esophagus, and identified a significant reduction in the 16A/16B ratio (P = 0.014) and an accompanying significant increase in the MYC/WAF1 expression ratio (P = 0.001) with progression from normal mucosa to dysplasia. " 05/01/2007 - "Taken together, these data demonstrate the efficacy of disrupting the beta-catenin/TCF transcriptional complex to exploit tumor dependence on Wnt signaling as a therapeutic approach in the treatment of MM." 08/01/2008 - "Inhibitors of the Tcf/beta-catenin complex may prove useful in the treatment of adrenocortical tumors in which multiple genetic alterations have accumulated."
2.	Colorectal Neoplasms (Colorectal Cancer) 07/01/2010 - "Increasing beta-catenin expression in the cytoplasm was associated with improved survival for colorectal cancer cases on both univariate (P = 0.003) and multivariate (P = 0.01) analysis. " 06/01/2008 - "Our study identifies DACT3 as an important regulator of Wnt/beta-catenin signaling in colorectal cancer and suggests a potential strategy for therapeutic control of Wnt/beta-catenin signaling in colorectal cancer." 01/01/2008 - "Further studies on Wnt/beta-catenin and MMP-7 gene activity and protein expression are necessary to better understand the pathogenesis of colorectal carcinoma." 01/01/2008 - "To study the dynamic events leading to impaired cell-cell adhesion upon transition to the invasive phenotype of colorectal cancer (CRC), we examined three distinct beta-catenin expression patterns (membranous, cytoplasmic, and nuclear) in the paired samples of the primary tumours (P) and their metastatic lesions (M). " 05/01/2007 - "L1, a new target gene for Wnt/beta-catenin-TCF signaling, has been identified in the invasive front of colorectal cancer cells in vitro study. "
3.	Adenoma (Adenomas) 08/01/2008 - "Min mice treated systemically with beta-catenin AODNs over a 6-week period had a statistically significant reduction in the number of intestinal adenomas. " 08/01/2008 - "ANALYSIS OF beta-CATENIN PROTEIN EXPRESSION IN LIVER TISSUE AND INTESTINAL ADENOMAS: Adenomas harvested from mice treated for 7 days with beta-catenin AODNs demonstrated clear downregulation of beta-catenin expression, which was accompanied by a significant reduction in proliferation. " 06/04/2007 - "However, nuclear beta-catenin expression was significantly greater in MCRA patients' tumours than in sporadic adenomas. " 04/01/2009 - "This study was performed to characterize the clinicopathological features and examine activation of the Wnt/beta-catenin pathway in LSTs and protruded-type colorectal adenomas (PAs). " 08/01/2008 - "These studies provide direct evidence that targeted suppression of beta-catenin inhibits the formation of intestinal adenomas in APC-mutant mice. "
4.	Carcinoma (Carcinomatosis) 01/01/2014 - "These results suggest that mucinous breast carcinomas express some markers of intestinal differentiation, such as MUC-2 and beta-catenin; however, future studies with a larger series of cases and using molecular techniques that help affirm these results are needed." 09/01/2011 - "In this study, we used lentivirus-mediated RNA interference (RNAi) targeted against beta-catenin to determine the effects of decreasing the high constitutive level of this protein in human tongue carcinoma cell line Tca8113. " 04/01/2006 - "Study of phospho-beta-catenin subcellular distribution in invasive breast carcinomas in relation to their phenotype and the clinical outcome." 10/01/2004 - "Recent studies have associated PTEN mutations with tumorigenesis of prostate carcinoma via the Wnt signaling pathway, leading to nuclear beta-catenin accumulation. " 04/30/2004 - "Recent studies have revealed the presence of beta-catenin mutations in a small subset of human and rat lung carcinomas, suggesting the involvement of the Wnt pathway in pulmonary carcinogenesis. "
5.	Neoplasm Metastasis (Metastasis) 01/01/2011 - "The purpose of this study is to investigate whether nuclear beta-catenin overexpression in metastatic sentinel lymph node(s) [SLN(s)] is associated with synchronous liver metastasis. " 08/01/2015 - "The abnormal expression rates of Tcf4 and beta-catenin were also related to the lymph node metastasis and Dukes stage (P<0.05). " 12/01/2014 - "Nek2 and beta-catenin expression were examined by immunohistochemistry in a series of resected CRC, as well as their matched lymph node and liver metastases, and correlated with clinicopathological characteristics. " 01/01/2014 - "The main effector of the Wnt signaling, beta-catenin, was up-regulated in 56%, and transferred to the nucleus in 36% of metastases. " 07/01/2011 - "The main effector of the wnt signaling, beta-catenin, was upregulated in 42.9% of cases and transferred to the nucleus in 28.6% of metastasis cases. "

Related Drugs and Biologics

1.	Cadherins (E-Cadherin)
2.	Cyclin D1
3.	Messenger RNA (mRNA)
4.	glycogen synthase kinase 3 beta
5.	Transcription Factors (Transcription Factor)
6.	Glycogen Synthase Kinases
7.	Azoxymethane
8.	Dimenhydrinate (DMH)
9.	Sulindac (Copal)
10.	1,2-Dimethylhydrazine (1,2 Dimethylhydrazine)

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Chemoprevention
3.	Lasers (Laser)
4.	Therapeutics
5.	Adjuvant Chemotherapy