HOME PRODUCTS SERVICES COMPANY CONTACT FAQ

Clusterin

A highly conserved heterodimeric glycoprotein that is differentially expressed during many severe physiological disturbance states such as CANCER; APOPTOSIS; and various NEUROLOGICAL DISORDERS. Clusterin is ubiquitously expressed and appears to function as a secreted MOLECULAR CHAPERONE.

Also Known As:

ApoJ Protein; Apolipoprotein J; Complement Lysis Inhibitor; Complement-Associated Protein SP-40,40; Ionizing Radiation-Induced Protein-8; MAC393 Antigen; SGP-2 Protein; SP 40,40 Protein; Sulfated Glycoprotein 2; Sulfated Glycoprotein-2; TRPM-2 Protein; Testosterone-Repressed Prostate Message-2 Protein; X-Ray-Inducible Protein 8; XIP8 Protein; 40,40 Protein, SP; Complement Associated Protein SP 40,40; Ionizing Radiation Induced Protein 8; Radiation-Induced Protein-8, Ionizing; SGP 2 Protein; SP-40,40, Complement-Associated Protein; TRPM 2 Protein; Testosterone Repressed Prostate Message 2 Protein; X Ray Inducible Protein 8

Networked: 791 relevant articles (21 outcomes, 142 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins
- Proteins: 90489
  - Glycoproteins: 18176
    - Clusterin: 791
  - Molecular Chaperones: 904
    - Clusterin: 791

Experts

1.	Gleave, Martin E: 37 articles (04/2014 - 02/2002)
2.	Gleave, Martin: 22 articles (11/2015 - 01/2002)
3.	Miyake, Hideaki: 20 articles (12/2014 - 01/2002)
4.	Bettuzzi, Saverio: 16 articles (01/2015 - 06/2002)
5.	Hara, Isao: 14 articles (09/2006 - 01/2002)
6.	Zoubeidi, Amina: 12 articles (09/2014 - 08/2008)
7.	Beraldi, Eliana: 9 articles (11/2015 - 03/2004)
8.	Fazli, Ladan: 9 articles (11/2015 - 03/2004)
9.	Chi, Kim N: 9 articles (08/2013 - 06/2004)
10.	Xie, Dan: 9 articles (05/2013 - 01/2005)

Related Diseases

1.	Neoplasms (Cancer) 04/01/2011 - "Because increased clusterin expression correlates with aggressive behavior in tumors, clusterin inhibition might be beneficial in cancer treatment. " 07/21/2015 - "Custirsen (OGX-011) is a novel 2'-methoxyethyl modified phosphorothioate antisense oligonucleotide that targets secretory clusterin protein expression and is currently in clinical trials for patients with different cancers. " 11/01/2009 - "This study highlights the potential of clusterin detection in stool to be a valuable tool to improve the effectiveness and efficiency of large-scale clinical cancer screening." 11/01/2009 - "Secreted clusterin isoform (sCLU) is cytoprotective and its prosurvival function is the basis of the current phase I/II clinical trials against prostate, lung, and breast cancers. " 08/01/2009 - "This study seeks to further characterize the immunophenotype of these tumors, and investigates the utility of clusterin as a diagnostic marker. "
2.	Prostatic Neoplasms (Prostate Cancer) 10/01/2008 - "Further studies revealed that clusterin is methylated in the TRAMP-C2 cell line, as well as in the human prostate cancer cell line LNCaP. " 09/01/2005 - "The objective of this study was to review our experience in the development of antisense (AS) oligodeoxynucleotide (ODN) therapy for prostate cancer targeting antiapoptotic gene, clusterin. " 02/01/2005 - "Our recent studies showed that antisense oligodeoxynucleotide targeting antiapoptotic gene, clusterin, enhanced apoptosis induced by conventional therapeutic modalities using several prostate cancer models. " 12/01/2004 - "In the present study, we investigated the effect of oxidative stress on cell injury using androgen-dependent human prostate cancer LNCaP cells overexpressing clusterin, which has been shown to play crucial roles in the acquisition of resistance to several apoptotic stimuli. " 01/01/2004 - "Results of this preliminary study support the important role of clusterin in the stromal component for prostate cancer progression. "
3.	Neoplasm Metastasis (Metastasis) 11/01/2014 - "Clusterin expression in gastrointestinal neuroendocrine tumours is highly correlated with location and is helpful in determining the origin of liver metastases." 09/01/2012 - "The aim of this study is to evaluate clusterin as a marker for evaluating diagnosis and metastasis potential of viral-related HCC. " 10/27/2015 - "Here, we identified the clusterin (CLU) gene that is also enriched in Lgr5+ intestinal stem cells, as a gene induced during L1-mediated CRC metastasis. " 11/01/2014 - "Clusterin expression in gastrointestinal NETs is highly correlated with location and probably also with grading, in both the primary tumour and metastases. " 09/01/2012 - "Clusterin might be deemed as a useful marker for predicting the progression and metastasis potential of HCC."
4.	Urinary Bladder Neoplasms (Bladder Cancer) 02/01/2005 - "Therapeutic efficacy of adenoviral-mediated p53 gene transfer is synergistically enhanced by combined use of antisense oligodeoxynucleotide targeting clusterin gene in a human bladder cancer model." 02/01/2005 - "These findings suggest that combined treatment with AS clusterin ODN and Ad5CMV-p53 could be a novel strategy to inhibit bladder cancer progression, and that further additional use of a chemotherapeutic agent may substantially enhance the efficacy of this combined regimen." 06/01/2005 - "This study was to analyze correlation of expression of clusterin protein to clinicopathologic parameters and prognosis of bladder cancer with tissue chip. " 05/01/2005 - "The objective of this study was to investigate whether radiation sensitivity was enhanced by suppressing clusterin gene expression with antisense (AS) oligodeoxynucleotide (ODN) in the human bladder cancer KoTCC-1 model. " 12/01/2001 - "Although recent studies have demonstrated a protective role of clusterin expression against various kinds of apoptotic stimuli, the functional role of clusterin in the acquisition of a therapy-resistant phenotype in bladder cancer remains unknown. "
5.	Lung Neoplasms (Lung Cancer) 11/15/2005 - "The purpose of this study was to determine whether inhibition of clusterin by an antisense-based investigative drug enhances radiation sensitization in a lung cancer model. " 03/01/2013 - "Clusterin expression may change in various human malignancies, including lung cancer. " 01/01/2009 - "Clusterin (CLU) and lung cancer." 11/15/2005 - "Clusterin as a therapeutic target for radiation sensitization in a lung cancer model." 03/01/2004 - "These findings identify clusterin as a valid therapeutic target in strategies employing novel multimodality therapy for advanced lung cancer."

Related Drugs and Biologics

1.	Hormones
2.	Cisplatin (Platino)
3.	Apolipoproteins E (ApoE)
4.	gemcitabine
5.	Zinc
6.	Paclitaxel (Taxol)
7.	Vitronectin
8.	docetaxel (Taxotere)
9.	Retinaldehyde (Retinal)
10.	Calpain

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Heterologous Transplantation (Xenotransplantation)
3.	Intravesical Administration
4.	Castration
5.	Radiotherapy