Clusterin

A highly conserved heterodimeric glycoprotein that is differentially expressed during many severe physiological disturbance states such as CANCER; APOPTOSIS; and various NEUROLOGICAL DISORDERS. Clusterin is ubiquitously expressed and appears to function as a secreted MOLECULAR CHAPERONE.

Also Known As:

ApoJ Protein; Apolipoprotein J; Complement Lysis Inhibitor; Complement-Associated Protein SP-40,40; Ionizing Radiation-Induced Protein-8; MAC393 Antigen; SGP-2 Protein; SP 40,40 Protein; Sulfated Glycoprotein 2; Sulfated Glycoprotein-2; TRPM-2 Protein; Testosterone-Repressed Prostate Message-2 Protein; X-Ray-Inducible Protein 8; XIP8 Protein; Complement Associated Protein SP 40,40; Ionizing Radiation Induced Protein 8; Radiation-Induced Protein-8, Ionizing; SGP 2 Protein; SP-40,40, Complement-Associated Protein; TRPM 2 Protein; Testosterone Repressed Prostate Message 2 Protein; X Ray Inducible Protein 8

Networked: 1259 relevant articles (28 outcomes, 209 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Gleave, Martin E: 43 articles (01/2022 - 02/2002)
2.	Gleave, Martin: 24 articles (01/2017 - 01/2002)
3.	Bettuzzi, Saverio: 21 articles (09/2020 - 06/2002)
4.	Miyake, Hideaki: 21 articles (01/2017 - 01/2002)
5.	Hara, Isao: 14 articles (09/2006 - 01/2002)
6.	Trougakos, Ioannis P: 13 articles (01/2022 - 10/2002)
7.	Wilson, Mark R: 13 articles (01/2022 - 08/2007)
8.	Zoubeidi, Amina: 13 articles (02/2017 - 08/2008)
9.	Rizzi, Federica: 12 articles (10/2021 - 01/2009)
10.	Xie, Dan: 11 articles (09/2021 - 01/2005)

Related Diseases

1.	Neoplasms (Cancer) 04/01/2011 - "Because increased clusterin expression correlates with aggressive behavior in tumors, clusterin inhibition might be beneficial in cancer treatment. " 01/01/2023 - "Retraction: Prognostic Role of Secretory Clusterin in Multiple Human Malignant Neoplasms: A Meta-Analysis of 26 Immunohistochemistry Studies." 01/01/2019 - "Inhibition of Clusterin is known to increase the cytotoxic effects of chemotherapeutic agents and improves advanced cancer patients survival in clinical trials. " 01/01/2018 - "The aim of this study was to investigate the effects of clusterin on cancer cell growth, invasion and S100A4 expression and to determine the effects of clusterin on in vitro cell proliferation and migration and in vivo tumour growth in RCC cells. " 05/01/2016 - "This study did not find relation between clusterin expression and disease recurrence, survival or any of the other clinicopathological parameters in endometrial tumors. "
2.	Prostatic Neoplasms (Prostate Cancer) 01/01/2018 - "Overall, results from this study provide insight into the potential biological pathways controlled by E6AP in prostate cancer cells and identifies clusterin as a novel target of E6AP." 10/01/2008 - "Further studies revealed that clusterin is methylated in the TRAMP-C2 cell line, as well as in the human prostate cancer cell line LNCaP. " 01/01/2004 - "Results of this preliminary study support the important role of clusterin in the stromal component for prostate cancer progression. " 11/22/2002 - "The objective of the present study was to examine the effects of clusterin on proliferation in a prostate cancer cell line, LNCaP. " 10/01/2002 - "The purpose of this study is to evaluate the role of the cell survival gene clusterin in radiation-induced cell death in human LNCaP and PC-3 prostate cancer models. "
3.	Urinary Bladder Neoplasms (Bladder Cancer) 02/01/2005 - "These findings suggest that combined treatment with AS clusterin ODN and Ad5CMV-p53 could be a novel strategy to inhibit bladder cancer progression, and that further additional use of a chemotherapeutic agent may substantially enhance the efficacy of this combined regimen." 03/01/2010 - "Serum and urine clusterin was significantly higher in individuals with bladder cancer than control (p = 0.001). " 03/01/2010 - "In addition, we analyzed the correlation of expression of clusterin in specimens of TCC to various clinicopathologic parameters and prognosis of bladder cancer. " 01/01/2006 - "In conclusion, serum and urine clusterin can differ between bladder cancer patients and the control group. " 01/01/2006 - "Urine values of clusterin were higher in individuals with bladder cancer (197.2 vs 67.7, p=0.0007). "
4.	Lung Neoplasms (Lung Cancer) 11/15/2005 - "The purpose of this study was to determine whether inhibition of clusterin by an antisense-based investigative drug enhances radiation sensitization in a lung cancer model. " 01/01/2020 - "Inactivation of tumor suppressor gene Clusterin leads to hyperactivation of TAK1-NF-κB signaling axis in lung cancer cells and denotes a therapeutic opportunity." 09/27/2017 - "In addition, we examined the correlation between clusterin and clinicopathological features of lung cancer. " 01/01/2009 - "Clusterin (CLU) and lung cancer." 11/15/2005 - "Clusterin as a therapeutic target for radiation sensitization in a lung cancer model."
5.	Proteinuria 03/01/1994 - "Kidneys perfused with clusterin depleted plasma developed significantly greater proteinuria at all time points when compared to control kidneys. " 12/01/2002 - "Urinary clusterin, representing a 0.01 fraction of serum, was higher in the urine from normal subjects and FSGS patients in remission with proteinuric MN, FSGS and idiopathic NS; clusterin was inversely correlated with proteinuria. " 12/01/2002 - "Serum clusterin was markedly reduced in active MN, in FSGS and in children with NS compared to controls; after stable remission of proteinuria, nearly normal levels were restored. " 03/01/2008 - "We studied proteinuria-induced renal disease and its influence on clusterin-mediated apoptosis. " 12/01/2007 - "Urinary clusterin measurement with ELISA test does not offer any advantage over routinely used parameters for nephropathy diagnosis and the differential diagnosis of proteinuria type."

Related Drugs and Biologics

1.	Oligodeoxyribonucleotides
2.	Hormones (Hormone)
3.	Cisplatin (Platino)
4.	Proteins (Proteins, Gene)
5.	Biomarkers (Surrogate Marker)
6.	OGX-011
7.	Antisense Oligonucleotides
8.	Glycoproteins (Glycoprotein)
9.	Interleukin-6 (Interleukin 6)
10.	Gemcitabine

Related Therapies and Procedures

1.	Therapeutics
2.	Drug Therapy (Chemotherapy)
3.	Intravesical Administration
4.	Radiotherapy
5.	Castration