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Selenoprotein W

A single SELENOCYSTEINE containing protein that binds reduced GLUTATHIONE and can act as an antioxidant.

Also Known As:

SelW Protein

Networked: 10 relevant articles (1 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Selenoproteins: 684
    - Selenoprotein W: 10
      - human SELENOW protein

Experts

1.	Chung, Youn Wook: 2 articles (01/2021 - 04/2002)
2.	Cheng, Wen-Hsing: 1 article (01/2021)
3.	Choi, Yongwon: 1 article (01/2021)
4.	Huang, Ying-Chen: 1 article (01/2021)
5.	Jeong, Daewon: 1 article (01/2021)
6.	Kim, Hyunsoo: 1 article (01/2021)
7.	Kim, Jae-Ryong: 1 article (01/2021)
8.	Kim, Jin Man: 1 article (01/2021)
9.	Kim, Mi Yeong: 1 article (01/2021)
10.	Kim, Nacksung: 1 article (01/2021)

Related Diseases

1.	Colitis 04/01/2023 - "Selenoprotein W Ameliorates Experimental Colitis and Promotes Intestinal Epithelial Repair."
2.	Inflammation (Inflammations) 11/01/2014 - "Possible correlation of selenoprotein W with inflammation factors in chicken skeletal muscles." 04/01/2023 - "Selenoprotein W (Selenow) is a ~9 kDa selenoprotein suggested to play a beneficial role in resolving inflammation. " 01/01/2023 - "Loss of selenoprotein W in murine macrophages alters the hierarchy of selenoprotein expression, redox tone, and mitochondrial functions during inflammation."
3.	Necrosis 01/06/2023 - "Seven genes are considered potential candidate genes for regulating antioxidant activity, including selenoprotein W, 1, glutathione peroxidase 1, glutathione S-transferase A1, tumour necrosis factor, tumour necrosis factor superfamily member 10, tumour necrosis factor superfamily member 8, and tumour necrosis factor superfamily member 13b. " 01/01/2021 - "Herein, we report the identification of selenoprotein W (SELENOW) through large-scale mRNA profiling of receptor activator of nuclear factor (NF)-κΒ ligand (RANKL)-induced osteoclast differentiation, as a protein that is downregulated via RANKL/RANK/tumour necrosis factor receptor-associated factor 6/p38 signaling. "
4.	Insulin Resistance 12/01/2019 - "Selenoprotein W deficiency does not affect oxidative stress and insulin sensitivity in the skeletal muscle of high-fat diet-fed obese mice." 01/01/2021 - "Dietary Se insufficiency decreased (P < 0.05) 1) glucose tolerance (13-79%) and insulin sensitivity (15-65%) at ≤0.10 mg Se/kg; 2) baseline thymoma viral proto-oncogene phosphorylation on S473 (27-54%) and T308 (22-46%) at ≤0.10 and ≤0.07 mg Se/kg, respectively, in the muscle but not the liver; and 3) serum glutathione peroxidase 3 (51-83%), liver and muscle glutathione peroxidase 1 (32-84%), serum and liver selenoprotein P (28-42%), and liver and muscle selenoprotein H (39-48%) and selenoprotein W (16-73%) protein concentrations at ≤0.04, ≤0.10, ≤0.07, and ≤0.10 mg Se/kg, respectively. "
5.	Thymoma (Thymic Carcinoma) 01/01/2021 - "Dietary Se insufficiency decreased (P < 0.05) 1) glucose tolerance (13-79%) and insulin sensitivity (15-65%) at ≤0.10 mg Se/kg; 2) baseline thymoma viral proto-oncogene phosphorylation on S473 (27-54%) and T308 (22-46%) at ≤0.10 and ≤0.07 mg Se/kg, respectively, in the muscle but not the liver; and 3) serum glutathione peroxidase 3 (51-83%), liver and muscle glutathione peroxidase 1 (32-84%), serum and liver selenoprotein P (28-42%), and liver and muscle selenoprotein H (39-48%) and selenoprotein W (16-73%) protein concentrations at ≤0.04, ≤0.10, ≤0.07, and ≤0.10 mg Se/kg, respectively. "

Related Drugs and Biologics

1.	Selenoproteins (Selenoprotein)
2.	Proteins (Proteins, Gene)
3.	Glutathione Peroxidase GPX1
4.	Early Growth Response Protein 1
5.	Selenoprotein P
6.	Complementary DNA (cDNA)
7.	Selenium
8.	Messenger RNA (mRNA)
9.	Ligands
10.	Glutathione Transferase (Glutathione S-Transferase)