Selenoproteins (Selenoprotein)

Selenoproteins are proteins that specifically incorporate SELENOCYSTEINE into their amino acid chain. Most selenoproteins are enzymes with the selenocysteine residues being responsible for their catalytic functions.

Also Known As:

Networked: 315 relevant articles (8 outcomes, 45 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Carlson, Bradley A: 24 articles (08/2015 - 12/2005)
2.	Hatfield, Dolph L: 21 articles (08/2015 - 12/2005)
3.	Gladyshev, Vadim N: 17 articles (01/2015 - 12/2005)
4.	Berry, Marla J: 11 articles (10/2015 - 07/2003)
5.	Schomburg, Lutz: 10 articles (05/2014 - 06/2009)
6.	Ferreiro, Ana: 9 articles (01/2011 - 10/2002)
7.	Tsuji, Petra A: 8 articles (08/2015 - 05/2010)
8.	Schweizer, Ulrich: 8 articles (05/2014 - 06/2009)
9.	Guicheney, Pascale: 8 articles (10/2012 - 10/2002)
10.	Méplan, Catherine: 7 articles (05/2015 - 11/2009)

Related Diseases

1.	Neoplasms (Cancer) 04/01/2013 - "Although the epidemiological data are somewhat controversial, the results of many studies suggest that inorganic and organic forms of Se negatively affect cancer progression, and that several selenoproteins, such as GPXs, also play important roles in tumor development. " 06/01/2012 - "The purpose of this study was to determine whether selenoproteins mitigate the risk of developing chemically induced mammary cancer. " 11/01/2008 - "Transgenic mice that express reduced levels of selenoproteins and previously shown to be more susceptible to pathology associated with cancer development were used to study this possibility. " 12/02/2015 - "Malfunctions of selenoproteins lead to various human disorders including cancer. " 10/01/2015 - "Significant correlations were found between selenoprotein genes and the cancer signaling-related genes Caspase3, P53, Bc1-2A, and Bc1-2B. "
2.	Inflammation 07/15/2015 - "Changes in cellular oxidative state coupled with altered expression of selenoproteins in macrophages drive the switch from a proinflammatory phenotype to an anti-inflammatory phenotype to efficiently resolve inflammation in the gut and restore epithelial barrier integrity. " 07/15/2015 - "We have focused on a few selenoproteins that mediate gastrointestinal inflammation and activate the host immune response, wherein macrophages play a pivotal role. " 12/01/2014 - "Supranutritional organic Se supplementation may be beneficial because selenoproteins are involved in regulating oxidative stress and inflammation. " 06/01/2014 - "The results show for the first time that selenoproteins are important for the balanced biosynthesis of pro- and anti-inflammatory oxylipids during inflammation. " 09/01/2013 - "Selenoprotein S (SelS), which is an endoplasmic reticulum resident protein, is known to promote cell survival by regulating inflammation. "
3.	Colonic Neoplasms (Colon Cancer) 09/01/2011 - "Recent studies in a mouse colon cancer cell line have shown that the 15 kDa selenoprotein (Sep15) may also play a role in promoting colon cancer. " 09/01/2011 - "Deficiency in the 15 kDa selenoprotein inhibits human colon cancer cell growth." 05/01/2006 - "These results provide evidence that a lack of selenoprotein activity increases colon cancer susceptibility. " 01/01/2012 - "Our previous observations demonstrated that targeted down-regulation of the 15 kDa selenoprotein (Sep15) in murine colon cancer cells resulted in the reversal of the cancer phenotype. " 05/01/2010 - "Deficiency in the 15-kDa selenoprotein inhibits tumorigenicity and metastasis of colon cancer cells."
4.	Inflammatory Bowel Diseases (Inflammatory Bowel Disease) 06/01/2014 - "While the cause-effect relationship of these observations remains to be clarified, the beneficial outcome of dietary Se supplementation and an optimization of selenoprotein biosynthesis in murine inflammatory bowel disease models have led to investigations of targets and actions of Se in the gastrointestinal tract. " 06/01/2014 - "This review discusses the role of Se and intestinal selenoproteins in inflammatory bowel diseases, based on data from human, animal, and in vitro studies. " 09/01/2007 - "The role of the selenoprotein S (SELS) gene -105G>A promoter polymorphism in inflammatory bowel disease and regulation of SELS gene expression in intestinal inflammation." 06/01/2014 - "Selenium and selenoproteins in inflammatory bowel diseases and experimental colitis."
5.	Autoimmune Thyroiditis (Lymphomatous Thyroiditis) 01/01/2007 - "Efficacy of selenium treatment in autoimmune thyroiditis demands an intact selenoprotein transport network." 10/01/2015 - "The aim of the present study was to investigate the effects of selenium on the incidence and severity of AIT, titers of thyroid autoantibodies, and selenoprotein expression in thyroid in a spontaneous autoimmune thyroiditis (SAT) model. "

Related Drugs and Biologics

1.	Selenium
2.	Selenoproteins (Selenoprotein)
3.	Selenoprotein P
4.	Reactive Oxygen Species (Oxygen Radicals)
5.	Glutathione Peroxidase
6.	Selenocysteine
7.	Transfer RNA (tRNA)
8.	Thioredoxin-Disulfide Reductase
9.	Messenger RNA (mRNA)
10.	Enzymes

Related Therapies and Procedures

1.	Chemoprevention
2.	Drug Therapy (Chemotherapy)
3.	Immunomodulation
4.	Intensive Care (Surgical Intensive Care)
5.	Prostatectomy (Retropubic Prostatectomy)