Serine C-Palmitoyltransferase

A key enzyme in SPHINGOLIPIDS biosynthesis, this enzyme catalyzes the pyridoxal-5'-phosphate-dependent condensation of L-SERINE and PALMITOYL COENZYME A to 3-dehydro-D-sphinganine. The enzyme consists of two different subunits.

Also Known As:

Long Chain Base Biosynthesis Protein 1; Long Chain Base Biosynthesis Protein 2; Palmitoyl-CoA-L-Serine C-Palmitoyltransferase (Decarboxylating); Palmitoyl-Coenzyme A-L-Serine C-Palmitoyltransferase (Decarboxylating); Serine Palmitoyltransferase; Serine Palmitoyltransferase 1; Serine Palmitoyltransferase 2; Serine Palmitoyltransferase, Long Chain Base Subunit 1; Serine Palmitoyltransferase, Long Chain Base Subunit 2; Serine-Palmitoyl-CoA Transferase 2; C-Palmitoyltransferase, Serine; Palmitoyltransferase 1, Serine; Palmitoyltransferase 2, Serine; Palmitoyltransferase, Serine; Serine C Palmitoyltransferase; Serine Palmitoyl CoA Transferase 2; Transferase 2, Serine-Palmitoyl-CoA

Networked: 93 relevant articles (3 outcomes, 9 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Transferases: 6589
    - Acyltransferases: 374
      - Serine C-Palmitoyltransferase: 93
        Arabidopsis LCB1 protein
        Arabidopsis Lcb2 protein
        human SPTLC1 protein
        human SPTLC2 protein
        human SPTLC3 protein
        human SPTSSB protein
        mouse Sptlc1 protein
        mouse Sptlc2 protein
        mouse SPTLC3 protein
        S cerevisiae LCB1 protein
        S cerevisiae LCB2 protein
        ssSPTa

Experts

1.	Hornemann, Thorsten: 11 articles (11/2022 - 04/2009)
2.	Timmerman, Vincent: 6 articles (01/2019 - 10/2002)
3.	Park, Tae-Sik: 5 articles (01/2022 - 07/2008)
4.	Penno, Anke: 5 articles (01/2021 - 04/2009)
5.	Auer-Grumbach, Michaela: 5 articles (01/2019 - 10/2002)
6.	Nicholson, Garth A: 4 articles (07/2014 - 10/2002)
7.	Lone, Museer A: 3 articles (11/2022 - 01/2021)
8.	Handzlik, Michal K: 3 articles (10/2021 - 10/2019)
9.	Metallo, Christian M: 3 articles (10/2021 - 10/2019)
10.	Othman, Alaa: 3 articles (01/2021 - 03/2016)

Related Diseases

1.	Inflammation (Inflammations) 01/01/2019 - "The present study uses astrocyte-neuron cocultures to investigate how ARN14494, a serine palmitoyltransferase (SPT) inhibitor, affects the CNS in terms of anti-inflammation and neuroprotection. " 10/01/2020 - "Levels of XBP1 and serine palmitoyltransferase were increased in liver tissues, and numbers of EVs were increased in plasma, from patients with NASH compared with control samples and correlated with the histologic features of inflammation. " 01/01/2019 - "ORMDL3 is known to regulate sphingolipid synthesis by binding serine palmitoyltransferase, but its role in inflammation is incompletely understood. " 10/01/2021 - "However, inhibition of serine palmitoyltransferase, the initial enzyme in ceramide biosynthesis, improved meibomian gland metabolism and morphology in SCD1-deficient mice, resulting in normal cell differentiation and reduced inflammation infiltration, cell apoptosis, and keratinization. " 01/01/2023 - "Although ORMDL3 is a member of a family that negatively regulates serine palmitoyltransferase (SPT) and thus biosynthesis of sphingolipids, it is still unclear whether ORMDL3 and altered sphingolipid synthesis are causally related to non-Th2 severe asthma associated with a predominant neutrophil inflammation and high interleukin-17 (IL-17) levels. "
2.	Fatty Liver 01/01/2022 - "Previously we showed that myriocin, a serine palmitoyltransferase inhibitor, ameliorates experimental alcohol-induced steatohepatitis. " 01/01/2011 - "Examples include the pharmacological inhibition of serine palmitoyltransferase or glucosylceramide synthase or the genetic depletion of acid sphingomyelinase, which dramatically reduce hepatic triglyceride levels in mice susceptible to the development of a fatty liver. "
3.	Cicatrix (Scar) 01/01/2012 - "Focussing on genes in the latter class, RNAi-mediated knockdown of the small GTPase Rab5, the prenylated SNARE protein YKT6, one sub-unit of serine palmitoyltransferase (spt2/lace), the Rac1-associated protein Sra1 and the actin cytoskeleton regulatory protein, SCAR, all lead to a significant reduction in parasite phagocytosis. "
4.	Atherosclerosis 04/01/2013 - "Myeloid cell-specific serine palmitoyltransferase subunit 2 haploinsufficiency reduces murine atherosclerosis." 07/01/1986 - "Enzymology of long-chain base synthesis by aorta: induction of serine palmitoyltransferase activity in rabbit aorta during atherogenesis." 07/01/1986 - "Rabbits, fed a Purina lab chow supplemented with 2% cholesterol, were used to study serine palmitoyltransferase activity in aorta during experimental atherogenesis. " 09/11/2009 - "Conversely, atherosclerosis is reduced in mice by blocking de novo synthesis of sphingolipids catalyzed by serine palmitoyltransferase (SPT). " 07/01/1986 - "Thus, the accumulation of sphingomyelin that occurs in aorta during experimental atherogenesis may be related to increased long-chain base synthesis by serine palmitoyltransferase."
5.	Hereditary Sensory and Autonomic Neuropathies (HSAN) 01/01/2019 - "Here, we report that HSAN-I-associated mutations in serine palmitoyltransferase subunit SPTLC2 dampened human T cell responses. " 07/01/2014 - "Mutations in serine palmitoyltransferase long chain subunit 1 (SPTLC1) cause the typical length-dependent axonal degeneration hereditary sensory neuropathy type 1 (HSN1). " 02/01/2014 - "The major underlying causes of HSAN I are mutations in SPTLC1, which encodes the first subunit of serine palmitoyltransferase (SPT). " 05/01/2013 - "Mutations in the serine palmitoyltransferase subunit 1 (SPTLC1) gene are the most common cause of hereditary sensory neuropathy type 1 (HSN1). " 01/01/2013 - "Glial knockdown of lace, a subunit of the serine palmitoyltransferase associated with hereditary sensory and autonomic neuropathies in humans, resulted in ensheathment defects of peripheral nerves in Drosophila. "

Related Drugs and Biologics

1.	thermozymocidin (myriocin)
2.	Ceramides
3.	Proteins (Proteins, Gene)
4.	Enzymes
5.	SNARE Proteins (SNAREs)
6.	Monomeric GTP-Binding Proteins
7.	Sphingolipids
8.	dihydroceramide desaturase
9.	Sphingomyelins
10.	Serine (L-Serine)

Related Therapies and Procedures

1.	Therapeutics