Glial Cell Line-Derived Neurotrophic Factor (GDNF)

The founding member of the glial cell line-derived neurotrophic factor family. It was originally characterized as a NERVE GROWTH FACTOR promoting the survival of MIDBRAIN dopaminergic NEURONS, and it has been studied as a potential treatment for PARKINSON DISEASE.

Also Known As:

Networked: 1263 relevant articles (96 outcomes, 223 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Gerhardt, Greg A: 12 articles (03/2013 - 01/2002)
2.	Takahashi, Masahide: 12 articles (06/2011 - 01/2002)
3.	Gash, Don M: 12 articles (01/2010 - 10/2002)
4.	Wang, Y: 11 articles (09/2003 - 01/2000)
5.	Svendsen, Clive N: 10 articles (04/2014 - 05/2003)
6.	Kiuchi, Kazutoshi: 10 articles (10/2012 - 01/2002)
7.	Takebayashi, Minoru: 9 articles (05/2013 - 03/2004)
8.	Forsayeth, John: 8 articles (01/2015 - 05/2009)
9.	Bähr, Mathias: 8 articles (05/2014 - 05/2003)
10.	Aebischer, Patrick: 8 articles (08/2013 - 02/2003)

Related Diseases

1.	Parkinson Disease (Parkinson's Disease) 08/01/2011 - "The difference in neuroprotective efficacy of glial cell line-derived neurotrophic factor seen in our model and the commonly used neurotoxin models of Parkinson's disease, raises important issues pertinent to the interpretation of the results obtained in preclinical models of Parkinson's disease, and their relevance for the therapeutic use glial cell line-derived neurotrophic factor in patients with Parkinson's disease." 11/01/2011 - "Is GDNF beneficial in Parkinson disease?" 04/01/2006 - "Transient striatal delivery of GDNF via encapsulated cells leads to sustained behavioral improvement in a bilateral model of Parkinson disease." 05/01/2013 - "GDNF administration has recently been shown to be an effective treatment for Parkinson's disease, with clinical trials currently in progress. " 01/15/1999 - "Recent studies suggest that these GDNF gene therapy approaches are effective in rat models of Parkinson's disease. "
2.	Neurodegenerative Diseases (Neurodegenerative Disease) 04/15/2014 - "GDNF therapy is one of the suggested options in the treatment of neurodegenerative diseases. " 01/01/2013 - "The inducible expression of GDNF in hNSCs may provide a system for the controllable delivery of GDNF in patients with neurodegenerative diseases." 09/30/2010 - "In conclusion, the characterization of GDNF and NTN will certainly help elucidate the mechanism of DHA action, and lead to better strategies for the use of DHA to treat neurodegenerative diseases." 02/01/2009 - "Development of drug delivery technologies facilitating controlled release of GDNF is critical to applying GDNF in treating neurodegenerative diseases. " 07/01/2008 - "However, the actual role of endogenous GDNF in the normal adult brain is unknown, even though GDNF-based therapies are considered promising for neurodegenerative disorders. "
3.	Spinal Cord Injuries (Spinal Cord Injury) 04/01/2010 - "These results suggest that GDNF, acting through the MEK-ERK pathway enhances axonal sprouting, synaptic connectivity, and GABAergic neurotransmission in the spinal cord, that result in improved behavioral outcomes after spinal cord contusion injury." 06/01/2011 - "Thus, our study demonstrates a novel role of GDNF in modifying spinal cord injury (SCI)-induced astrogliosis resulting in robust axonal regeneration in adult rats." 04/01/2014 - "Genetically modified Schwann cells producing glial cell line-derived neurotrophic factor inhibit neuronal apoptosis in rat spinal cord injury." 01/01/2014 - "Adenoviral-mediated glial cell line-derived neurotrophic factor gene transfer has a protective effect on sciatic nerve following constriction-induced spinal cord injury." 04/01/2013 - "[Expression of gdnf and nos in adult zebrafish brain during the regeneration after spinal cord injury]."
4.	Wounds and Injuries (Trauma) 12/01/2010 - "This study gives insight into the potential beneficial role of GDNF in the treatment of motor nerve injuries." 12/01/2001 - "The present study shows that adenoviral GDNF delivery is protective in focal cortex trauma." 07/01/2010 - "Peripheral delivery of GDNF resulted in earlier regeneration following sciatic nerve crush injuries than that with central GDNF delivery. " 10/01/2003 - "This work demonstrates that intracerebral adeno-viral mediated GDNF gene transfer can protect dopaminergic neurons in vivo from 6-OHDA-induced injuries. " 05/01/2002 - "Using viral-mediated gene transfer, we overexpressed transgenic glial cell line-derived neurotrophic factor and demonstrated a robust protective effect against acoustic and ototoxic inner ear trauma. "
5.	Brain Injuries (Brain Injury) 03/01/2001 - "These results suggest that the successful exogenous GDNF gene transfer ameliorates the ischemic brain injury after transient MCAO in association with the reduction of apoptotic signals. " 12/01/1999 - "These results suggest that the successful exogenous GDNF gene transfer ameliorates ischemic brain injury after transient MCAO in association with the reduction of apoptotic signals." 05/01/2002 - "Protective effects of glial cell line-derived neurotrophic factor in ischemic brain injury." 10/01/2001 - "Protective effects of glial cell line-derived neurotrophic factor on hippocampal neurons after traumatic brain injury in rats." 04/01/2014 - "In this study, we examined the neuroprotective potential of amniotic fluid (AF) single cell clones, engineered to secrete glial cell derived neurotrophic factor (AF-GDNF), both in vitro and in a surgically induced model of brain injury. "

Related Drugs and Biologics

1.	Glial Cell Line-Derived Neurotrophic Factor (GDNF)
2.	Brain-Derived Neurotrophic Factor (BDNF)
3.	Nerve Growth Factor (NGF)
4.	Dopamine (Intropin)
5.	Nerve Growth Factors (Neurotrophins)
6.	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)
7.	Retinaldehyde (Retinal)
8.	Small Interfering RNA (siRNA)
9.	Memantine (Namenda)
10.	Uridine Diphosphate Glucose (UDP Glucose)

Related Therapies and Procedures

1.	Transplantation (Transplant Recipients)
2.	Tissue Therapy (Cell Therapy)
3.	Transplants (Transplant)
4.	Electroacupuncture
5.	Microbubbles