PTEN Phosphohydrolase (PTEN Phosphatase)

A lipid phosphatase that acts on phosphatidylinositol-3,4,5-trisphosphate to regulate various SIGNAL TRANSDUCTION PATHWAYS. It modulates CELL GROWTH PROCESSES; CELL MIGRATION; and APOPTOSIS. Mutations in PTEN are associated with COWDEN DISEASE and PROTEUS SYNDROME as well as NEOPLASTIC CELL TRANSFORMATION.

Also Known As:

Networked: 565 relevant articles (2 outcomes, 68 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Eng, Charis: 19 articles (03/2015 - 05/2002)
2.	Pandolfi, Pier Paolo: 9 articles (04/2014 - 10/2002)
3.	Leslie, Nick R: 9 articles (04/2014 - 01/2004)
4.	De Marzo, Angelo M: 6 articles (03/2015 - 10/2011)
5.	Pulido, Rafael: 6 articles (11/2011 - 08/2003)
6.	Evers, B Mark: 6 articles (04/2011 - 09/2002)
7.	Waite, Kristin A: 6 articles (01/2008 - 03/2003)
8.	Lotan, Tamara L: 5 articles (03/2015 - 10/2011)
9.	He, Xin: 5 articles (12/2012 - 11/2010)
10.	Parsons, Ramon: 4 articles (01/2016 - 04/2002)

Related Diseases

1.	Neoplasms (Cancer) 11/01/2013 - "In this regard, a newly identified isoform of the PTEN protein shows promise for use in tumors with elevated PI3K/Akt/mTOR signaling. " 09/01/2008 - "Therefore the present study reveals that the C-terminus of PTEN plays a critical role in stabilizing PTEN via antagonizing NEDD4-1-induced PTEN protein decay; conversely, truncation of the PTEN C-terminus results in rapid NEDD4-1-mediated PTEN degradation, a possible mechanism accounting for attenuation of PTEN function by certain PTEN mutations in human cancers." 01/01/2008 - "A new study shows that microdeletions in PTEN, resulting in complete loss of PTEN protein, are signature lesions in these cancers, particularly those arising in BRCA1-mutation carriers." 10/19/2001 - "In this study, we demonstrate that expression of Bcl-2 in prostate tumors correlates with loss of the PTEN protein. " 05/01/2015 - "The dual lipid and protein phosphatase PTEN is a tumor suppressor controlling key biological processes, such as cell growth, proliferation and neuro-survival. "
2.	Colorectal Neoplasms (Colorectal Cancer) 01/01/2013 - "The aim of this study was to investigate the expression of MMP-7 and PTEN protein in colorectal cancer and explore its correlation with clinicopathological parameters. " 04/01/2014 - "B7-H1 immunoreactivities were found in 54.5% (55/101) of the colorectal cancer tissues with no expression in the normal tissues, and the PTEN protein immunoreactivities were observed in 51.5% (52/101) of the colorectal cancer tissues and 72.3% (73/101) of the normal tissues. " 11/01/2013 - "PTEN phosphatase-independent maintenance of glandular morphology in a predictive colorectal cancer model system." 01/01/2010 - "The PTEN phosphatase controls intestinal epithelial cell polarity and barrier function: role in colorectal cancer progression." 11/01/2009 - "Decreased PTEN protein and increased AKT protein might be a marker for the early detection of the occurrence of colorectal cancer in patients with UC."
3.	Endometrial Neoplasms (Endometrial Cancer) 12/01/2004 - "Significance of PTEN alterations in endometrial carcinoma: a population-based study of mutations, promoter methylation and PTEN protein expression." 05/01/2004 - "Three different human endometrial cancer cell lines known to have wild-type PTEN (HEC 1-A) or a mutated inactive PTEN protein (RL 95-2 and Ishikawa) were used for these studies. " 03/11/2004 - "Three different human endometrial cancer cell lines known to have wild type PTEN (HEC 1-A) or a mutated inactive PTEN protein (RL 95-2 and Ishikawa) were used for these studies. " 09/01/2003 - "In the present study, we have used an endometrial cancer cell line known to possess wild-type PTEN (HEC-1-A) and two mutated inactive PTEN protein cell lines (RL-95-2 and Ishikawa) to investigate importance of PI 3-K/PTEN/Akt survival pathway in endometrial cancers. " 11/01/2002 - "In this study, we evaluated the alteration of PTEN protein expression in endometrial carcinoma and assessed its relationship to the expression of p27, the presumed downstream target of PTEN. "
4.	Breast Neoplasms (Breast Cancer) 07/03/2008 - "These studies indicate that disruption of the normal activity of the PTEN phosphatase can have dramatic effects on the therapeutic sensitivity of breast cancer cells. " 01/01/2005 - "The aim of this study was to analyze PTEN protein expression in breast cancer and to evaluate the prognostic significance of PTEN protein expression. " 06/01/2015 - "Loss of PTEN protein expression occurs at high frequency in Middle Eastern breast cancer. " 03/01/2014 - "Increased circulating levels of PTEN and phosphorylated PTEN protein were also observed by immunostaining in patients with breast cancer and precursor breast lesions. " 07/21/2011 - "Our findings provide a rationale to guide selection of breast cancer patients who may benefit from mTOR inhibitor therapy and highlight the importance of accurately assessing the expression of PTEN protein and not just its mutational status."
5.	Adenocarcinoma 06/01/2009 - "Immunohistochemistry study of PTEN protein was performed on 42 cases of cervical adenocarcinoma, 20 cases of cervical glandular intraepithelial neoplasia and 28 cases of normal cervix tissue samples. " 03/01/2004 - "This study was designed to investigate the role of survivin gene and PTEN protein in the pathogenesis of colorectal adenocarcinoma and their correlation. " 06/01/2009 - "Positive expression rates of PTEN protein were 47.4% (9/19), 20.0% (2/10) and 92.3% (12/13) in mucinous, endometrioid and the other variants of cervical adenocarcinoma, respectively. " 06/01/2009 - "Positive expression rates of PTEN protein were 54.8% (23/42), 25.0% (5/20) and 100% (28/28) in cervical adenocarcinoma, cervical glandular intraepithelial neoplasia and normal cervix tissues, respectively. " 01/01/2006 - "Immunohistochemical evaluation of PTEN protein in patients with endometrial intraepithelial neoplasia compared to endometrial adenocarcinoma and proliferative phase endometrium."

Related Drugs and Biologics

1.	cetuximab (Erbitux)
2.	thymidine 5'-triphosphate (TTP)
3.	tensins (tensin)
4.	Phosphotransferases (Kinase)
5.	Messenger RNA (mRNA)
6.	Epidermal Growth Factor Receptor (EGF Receptor)
7.	PTEN Phosphohydrolase (PTEN Phosphatase)
8.	trastuzumab (Herceptin)
9.	Chemokine CXCL12
10.	Phosphatidylinositol 3-Kinase (1 Phosphatidylinositol 3 Kinase)

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Prostatectomy (Retropubic Prostatectomy)
3.	Curettage
4.	Heterologous Transplantation (Xenotransplantation)
5.	Angioplasty (Angioplasty, Transluminal)