Sphingosine N-Acyltransferase

An enzyme that catalyzes the acyltransferase of SPHINGOSINE to N-acylsphingosine using acyl-COENZYME A as donor and COENZYME A as acceptor. The enzyme is mainly localized in the MITOCHONDRIA.

Also Known As:

Ceramide Synthetase; Fatty Acyl-CoA - Sphingosine Acyltransferase; Sphingosine Acyltransferase; Acyltransferase, Sphingosine; Fatty Acyl CoA Sphingosine Acyltransferase; N-Acyltransferase, Sphingosine; Sphingosine N Acyltransferase; Synthetase, Ceramide

Networked: 3 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Fujita, Masayo: 1 article (08/2009)
2.	Hashimoto, Makoto: 1 article (08/2009)
3.	Sekigawa, Akio: 1 article (08/2009)
4.	Sekiyama, Kazunari: 1 article (08/2009)
5.	Waragai, Masaaki: 1 article (08/2009)
6.	Wei, Jianshe: 1 article (08/2009)
7.	Bailly, Christian: 1 article (06/2003)
8.	Hénichart, Jean-Pierre: 1 article (06/2003)
9.	Mimeault, Murielle: 1 article (06/2003)
10.	Pommery, Nicole: 1 article (06/2003)

Related Diseases

1.	Prostatic Neoplasms (Prostate Cancer) 06/15/2003 - "The apoptotic/necrotic responses induced by ANA on these prostatic cancer cells were also potentiated by the acidic ceramidase inhibitor, N-oleoylethanolamine and partially inhibited by the specific ceramide synthetase inhibitor, fumonisin B1 indicating that these cytotoxic actions of ANA might be induced via the cellular ceramide production. "
2.	Neuroblastoma 08/01/2009 - "In our recent publication, dementia with Lewy bodies (DLB)-linked neuroblastoma cells were treated with D-Threo-1-phenyl-2-decanoylamino-3-morpholino-1-propanol (PDMP), an inhibitor of glycosyl ceramide synthetase. "
3.	Necrosis 06/01/1999 - "Tumour necrosis factor, anti-fas antibody, radiation and anticancer drugs such as actinomycin D are known to induce apoptosis in several cell types through generation of ceramide by activation of the sphingomyelinase pathway or ceramide synthetase. "
4.	Dementia (Dementias) 08/01/2009 - "In our recent publication, dementia with Lewy bodies (DLB)-linked neuroblastoma cells were treated with D-Threo-1-phenyl-2-decanoylamino-3-morpholino-1-propanol (PDMP), an inhibitor of glycosyl ceramide synthetase. "

Related Drugs and Biologics

1.	Ceramides
2.	Ceramidases
3.	Sphingomyelin Phosphodiesterase (Sphingomyelinase)
4.	Dactinomycin (Actinomycin)
5.	fumonisin B1
6.	N-oleoylethanolamine
7.	RV 538 (PDMP)