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Inhibitor of Apoptosis Proteins

A conserved class of proteins that control APOPTOSIS in both VERTEBRATES and INVERTEBRATES. IAP proteins interact with and inhibit CASPASES, and they function as ANTI-APOPTOTIC PROTEINS. The protein class is defined by an approximately 80-amino acid motif called the baculoviral inhibitor of apoptosis repeat; some members have ubiquitin-protein ligase activity.
Also Known As:
BIRC2 Protein; Baculoviral IAP Repeat Containing Protein 2; Baculoviral IAP Repeat-Containing 2 Protein; Baculoviral Inhibitor Of Apoptosis Repeat Proteins; Cellular Inhibitor of Apoptosis 1 Protein; IAP Protein (Apoptosis); IAP Repeat Containing Proteins; IAP2 Protein; Inhibitor of Apoptosis 2 Protein; Inhibitor-Of-Apoptosis Protein; c-IAP1 Protein; cIAP1 Protein; Apoptosis Proteins Inhibitor; Baculoviral IAP Repeat Containing 2 Protein; Inhibitor Of Apoptosis Protein
Networked: 717 relevant articles (10 outcomes, 53 trials/studies)

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Bio-Agent Context: Research Results

Experts

1. Fulda, Simone: 11 articles (01/2020 - 01/2004)
2. Wang, Shaomeng: 11 articles (04/2016 - 02/2005)
3. Liu, Yang: 10 articles (05/2021 - 05/2016)
4. Feng, Lin: 9 articles (03/2018 - 05/2016)
5. Jiang, Wei-Dan: 9 articles (03/2018 - 05/2016)
6. Kuang, Sheng-Yao: 9 articles (03/2018 - 05/2016)
7. Tang, Ling: 9 articles (03/2018 - 05/2016)
8. Wu, Pei: 9 articles (03/2018 - 05/2016)
9. Zhang, Yong-An: 9 articles (03/2018 - 05/2016)
10. Zhou, Xiao-Qiu: 9 articles (03/2018 - 05/2016)

Related Diseases

1. Pancreatic Neoplasms (Pancreatic Cancer)
2. B-Cell Lymphoma (Lymphoma, B Cell)
11/01/2006 - "Inhibitor of apoptosis proteins are differentially expressed in B-cell lymphomas. "
01/01/2014 - "This review highlights the recent advancements in the development of small-molecule inhibitors targeting three major classes of antiapoptotic proteins: antiapoptotic B cell lymphoma 2 (BCL-2) proteins, inhibitor of apoptosis proteins (IAPs), and murine double-minute 2 (MDM2). "
10/01/2007 - "With respect to SAHA, OSU-HDAC42 exhibited greater apoptogenic potency, which was associated with reduced levels of the apoptotic regulators phosphorylated Akt B-cell lymphoma-xL, survivin, cellular inhibitor of apoptosis protein 1, and cellular inhibitor of apoptosis protein 2. The in vivo efficacy of OSU-HDAC42 versus SAHA was assessed in orthotopic and subcutaneous xenograft tumor models in athymic nude mice. "
12/01/2012 - "Cytokine-induced apoptosis inhibitor (CIAP) is a novel antiapoptotic molecule, which is different to inhibitor of apoptosis protein or B-cell lymphoma 2. CIAP was originally identified as a molecule that conferred resistance to apoptosis induced by growth factor starvation. "
01/14/2016 - "In this review, we reconnoitre the two major pathways (intrinsic and extrinsic) targeted cancer therapeutics, steering toward chief modulators of these pathways, such as B-cell lymphoma 2 protein family members (pro- and antiapoptotic), inhibitor of apoptosis proteins, and the foremost thespian of extrinsic pathway regulator, tumour necrosis factor-related apoptosis-inducing agent. "
3. Neoplasms (Cancer)
4. Squamous Cell Carcinoma of Head and Neck
5. Breast Neoplasms (Breast Cancer)

Related Drugs and Biologics

1. Survivin
2. Proteins (Proteins, Gene)
3. X-Linked Inhibitor of Apoptosis Protein
4. Caspase 3 (Caspase-3)
5. Fatty Acids (Saturated Fatty Acids)
6. SM 164
7. Gemcitabine
8. Ligands
9. Protein Kinases (Protein Kinase)
10. NF-kappa B (NF-kB)

Related Therapies and Procedures

1. Chemoradiotherapy
2. Therapeutics
3. Radiotherapy
4. Immunotherapy
5. Hepatectomy