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Inhibitor of Apoptosis Proteins

Subscribe to New Research on Inhibitor of Apoptosis Proteins

A conserved class of proteins that control APOPTOSIS in both VERTEBRATES and INVERTEBRATES. IAP proteins interact with and inhibit CASPASES, and they function as ANTI-APOPTOTIC PROTEINS. The protein class is defined by an approximately 80-amino acid motif called the baculoviral inhibitor of apoptosis repeat.

Also Known As:

Baculoviral Inhibitor Of Apoptosis Repeat Proteins; IAP Protein (Apoptosis); IAP1 Protein; IAP2 Protein; Inhibitor of Apoptosis 1 Protein; Inhibitor of Apoptosis 2 Protein; Inhibitor-Of-Apoptosis Protein; c-IAP1 Protein; c-IAP2 Protein; cIAP1 Protein; Apoptosis Proteins Inhibitor; Inhibitor Of Apoptosis Protein

Networked: 489 relevant articles (6 outcomes, 32 trials/studies)

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Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins
- Proteins: 90489
  - Intracellular Signaling Peptides and Proteins: 22
    - Apoptosis Regulatory Proteins: 520
      - Inhibitor of Apoptosis Proteins: 489
        X-Linked Inhibitor of Apoptosis Protein: 225
        Neuronal Apoptosis-Inhibitory Protein: 60
        Aedes triseriatus inhibitor of apoptosis 1 protein
        Drosophila DIAP2 protein
        Drosophila thread protein
        human BIRC2 protein
        human BIRC3 protein
        human BIRC6 protein
        human BIRC7 protein
        human BIRC8 protein
        mouse Birc2 protein
        mouse Birc3 protein
        mouse Birc4 protein
        mouse Birc5 protein
        mouse BIRC6 protein
        Nucleopolyhedrovirus inhibitor of apoptosis
        rat Birc3 protein
        rat Birc4 protein
        zebrafish survivin 1 protein
- Peptides: 22950
  - Intracellular Signaling Peptides and Proteins: 22
    - Apoptosis Regulatory Proteins: 520
      - Inhibitor of Apoptosis Proteins: 489
        X-Linked Inhibitor of Apoptosis Protein: 225
        Neuronal Apoptosis-Inhibitory Protein: 60
        Aedes triseriatus inhibitor of apoptosis 1 protein
        Drosophila DIAP2 protein
        Drosophila thread protein
        human BIRC2 protein
        human BIRC3 protein
        human BIRC6 protein
        human BIRC7 protein
        human BIRC8 protein
        mouse Birc2 protein
        mouse Birc3 protein
        mouse Birc4 protein
        mouse Birc5 protein
        mouse BIRC6 protein
        Nucleopolyhedrovirus inhibitor of apoptosis
        rat Birc3 protein
        rat Birc4 protein
        zebrafish survivin 1 protein

Experts

1.	Fulda, Simone: 9 articles (12/2015 - 01/2004)
2.	Wang, Shaomeng: 9 articles (04/2014 - 02/2005)
3.	Altieri, Dario C: 6 articles (04/2006 - 09/2002)
4.	Sun, Haiying: 5 articles (04/2014 - 02/2005)
5.	Sato, Noriyuki: 5 articles (11/2009 - 02/2005)
6.	Hirohashi, Yoshihiko: 5 articles (11/2009 - 02/2005)
7.	Torigoe, Toshihiko: 5 articles (11/2009 - 02/2005)
8.	Yang, Chao-Yie: 4 articles (04/2014 - 02/2005)
9.	Lu, Jianfeng: 4 articles (04/2014 - 11/2008)
10.	Fulda, S: 4 articles (01/2014 - 03/2007)

Related Diseases

1.	Neoplasms (Cancer) 10/01/2014 - "Phase I dose-escalation study of LCL161, an oral inhibitor of apoptosis proteins inhibitor, in patients with advanced solid tumors." 06/08/2007 - "Clinical studies have shown that nuclear expression of the inhibitor of apoptosis protein Survivin in tumor cells predicted a favorable prognosis whereas cytosolic-localized protein caused a decreased overall survival. " 02/01/2006 - "[Advances in studies on inhibitor of apoptosis proteins and cancer therapy]." 01/01/2016 - "The evasion of apoptosis is a hallmark of cancer, and is often due to the upregulation of inhibitor of apoptosis proteins (IAPs) in tumor cells. " 10/01/2015 - "Survivin, a member of the inhibitor of apoptosis protein family, is overexpressed in a variety of human neoplasms. "
2.	Pancreatic Neoplasms (Pancreatic Cancer) 01/01/2012 - "In the present study, we explored the antiproliferative action of VES and its effects on inhibitor of apoptosis proteins in pancreatic cancer cells. " 07/01/2011 - "The aim of this study was to investigate the inhibitor of apoptosis proteins survivin and XIAP in pancreatic cancer by determining their biological characteristics and expression. " 08/01/2007 - "Overexpression of cellular inhibitor of apoptosis protein 2 is an early event in the progression of pancreatic cancer." 10/01/2015 - "The efficacy of gemcitabine, a standard-of-care agent, combined with birinapant, a pro-apoptotic antagonist of Inhibitor of Apoptosis Proteins (IAPs), was investigated in pancreatic cancer cells. " 06/01/2009 - "To investigate the downregulation of survivin, an inhibitor of apoptosis protein with Smac and further analyze the sensitization to cisplatin chemotherapy in survivin-overexpressing pancreatic cancer BX-PC3 cell line with Smac transfection. "
3.	Infection 05/05/2015 - "We have shown that cellular inhibitor of apoptosis proteins (cIAPs) impair clearance of hepatitis B virus (HBV) infection by preventing TNF-mediated killing/death of infected cells. " 01/01/2014 - "Drosophila inhibitor of apoptosis protein 1 (DIAP1), which is related to caspase-dependent apoptosis, was also significantly upregulated after infection. " 03/01/2013 - "Prominent among these genes was the X chromosome-linked inhibitor of apoptosis protein (XIAP)-associated factor 1 (XAF1; up-regulated 1.2-fold in the microarray analysis and ∼8-fold by qRT-PCR after DENV2 infection). " 01/01/2008 - "monodon inhibitor of apoptosis protein (PmIAP) remained unchanged after white spot syndrome virus (WSSV) infection. " 02/01/2005 - "Lipopolysaccharide (LPS) is known to prolong the functional lifespan of neutrophils at a site of infection by preventing apoptosis through inhibitor of apoptosis proteins (IAPs). "
4.	B-Cell Lymphoma (Lymphoma, B Cell) 11/01/2006 - "Inhibitor of apoptosis proteins are differentially expressed in B-cell lymphomas. " 12/01/2012 - "Cytokine-induced apoptosis inhibitor (CIAP) is a novel antiapoptotic molecule, which is different to inhibitor of apoptosis protein or B-cell lymphoma 2. CIAP was originally identified as a molecule that conferred resistance to apoptosis induced by growth factor starvation. " 01/01/2014 - "This review highlights the recent advancements in the development of small-molecule inhibitors targeting three major classes of antiapoptotic proteins: antiapoptotic B cell lymphoma 2 (BCL-2) proteins, inhibitor of apoptosis proteins (IAPs), and murine double-minute 2 (MDM2). " 10/01/2007 - "With respect to SAHA, OSU-HDAC42 exhibited greater apoptogenic potency, which was associated with reduced levels of the apoptotic regulators phosphorylated Akt B-cell lymphoma-xL, survivin, cellular inhibitor of apoptosis protein 1, and cellular inhibitor of apoptosis protein 2. The in vivo efficacy of OSU-HDAC42 versus SAHA was assessed in orthotopic and subcutaneous xenograft tumor models in athymic nude mice. " 01/01/2013 - "CDDO-Me inhibited the expression of prosurvival phospho-AKT (p-AKT), phospho-mammalian target of rapamycin (p-mTOR) and nuclear factor-kappa B (NF-κB) (p65) signaling molecules and NF-κB-regulated antiapoptotic B-cell lymphoma-2 (BCL-2), B-cell lymphoma-extra large (BCL-xL), cellular inhibitor of apoptosis protein 1(c-IAP1) and survivin, but pre-treatment with NAC blocked the down-modulation of these signaling and antiapoptotic proteins by CDDO-Me. "
5.	Wounds and Injuries (Trauma) 09/01/2011 - "We investigated protective effects of quercetin on status epilepticus induced hippocampal neuronal injuries in rats and focused on two major proteins, the X-linked inhibitor of apoptosis protein, a key member of the inhibitor of apoptosis protein family, and the caspase-3 protein, a common effector for the execution-phase of cell signaling apoptotic pathways. " 09/01/2011 - "In parental and resistant cells there were analyzed the cell morphology (toluidine blue), the intracellular PpIX content (flow cytometry) and its localization (fluorescence microscopy), the capacity of closing wounds (scratch wound assay), the expression of cell-cell adhesion proteins (E-cadherin and β-catenin), cell-substrate adhesion proteins (β1-integrin, vinculin and phospho-FAK), cytoskeleton proteins (α-tubulin and F-actin) and the inhibitor of apoptosis protein survivin, in the activated form as phospho-survivin (indirect immunofluorescence and Western blot). "

Related Drugs and Biologics

1.	X-Linked Inhibitor of Apoptosis Protein
2.	gemcitabine
3.	Caspase 3 (Caspase-3)
4.	Proteins (Proteins, Gene)
5.	NF-kappa B (NF-kB)
6.	Protons (Proton)
7.	Messenger RNA (mRNA)
8.	Staphylococcal Protein A (A, Protein)
9.	Protein Kinases (Protein Kinase)
10.	Phosphotransferases (Kinase)

Related Therapies and Procedures

1.	Heterologous Transplantation (Xenotransplantation)
2.	Hepatectomy
3.	Drug Therapy (Chemotherapy)
4.	Radiotherapy
5.	Immunotherapy