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Apoptosis Inducing Factor

A flavoprotein that functions as a powerful antioxidant in the MITOCHONDRIA and promotes APOPTOSIS when released from the mitochondria. In mammalian cells AIF is released in response to pro-apoptotic protein members of the bcl-2 protein family. It translocates to the CELL NUCLEUS and binds DNA to stimulate CASPASE-independent CHROMATIN condensation.
Also Known As:
AIF Apoptosis Regulatory Protein; Apoptosis-Inducing Factor; Mitochondrial Apoptosis-Inducing Factor; Apoptosis-Inducing Factor, Mitochondrial; Mitochondrial Apoptosis Inducing Factor
Networked: 487 relevant articles (8 outcomes, 37 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Zhu, Changlian: 14 articles (02/2021 - 06/2003)
2. Blomgren, Klas: 12 articles (01/2020 - 06/2003)
3. Kroemer, Guido: 10 articles (01/2020 - 06/2003)
4. Hagberg, Henrik: 8 articles (01/2020 - 07/2003)
5. Wang, Xiaoyang: 8 articles (01/2020 - 07/2003)
6. Szabó, Csaba: 7 articles (01/2007 - 07/2002)
7. Culmsee, Carsten: 6 articles (12/2021 - 04/2004)
8. Sun, Yanyan: 6 articles (02/2021 - 04/2012)
9. Chung, Jing-Gung: 6 articles (09/2018 - 10/2009)
10. Li, Tao: 5 articles (02/2021 - 12/2018)

Related Diseases

1. Brain Ischemia (Cerebral Ischemia)
2. Mitochondrial Diseases (Mitochondrial Disease)
3. Ischemia
4. Brain Injuries (Brain Injury)
5. Leukemia

Related Drugs and Biologics

1. Cytochromes c (Cytochrome c)
2. Poly(ADP-ribose) Polymerases (Poly ADP Ribose Polymerase)
3. Caspase 3 (Caspase-3)
4. Acetaminophen (Paracetamol)
5. Glutamic Acid (Glutamate)
6. nigranoic acid
7. Cyclophilin A
8. Death Domain Receptors
9. Hepatocyte Growth Factor (Growth Factor, Hepatocyte)
10. Butyric Acid (Butanoic Acid)

Related Therapies and Procedures

1. Aftercare (After-Treatment)
2. Electroacupuncture
3. Therapeutics
4. Resuscitation
5. Photochemotherapy (Photodynamic Therapy)