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Phosphoribosylaminoimidazolecarboxamide Formyltransferase

An enzyme that catalyzes the conversion of aminoimidazole-4-carboxamide ribonucleotide to 5-formyl-aminoimidazole-4-carboxamide ribonucleotide in the purine de novo synthesis pathway. It requires the cofactor N(10)-FORMYLTETRAHYDROFOLATE as the formyl donor.
Also Known As:
AICAR Formyltransferase; AICAR Transformylase; AICARTFase; Aminoimidazolecarboxamide Ribonucleotide Transformylase; Formyltransferase, AICAR; Formyltransferase, Phosphoribosylaminoimidazolecarboxamide; Ribonucleotide Transformylase, Aminoimidazolecarboxamide; Transformylase, AICAR; Transformylase, Aminoimidazolecarboxamide Ribonucleotide; 5-amino-4-imidazolecarboxamide ribotide transformylase
Networked: 9 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Experts

1. Benkovic, Stephen J: 1 article (07/2012)
2. Birts, Charles N: 1 article (07/2012)
3. Blaydes, Jeremy P: 1 article (07/2012)
4. Cuda, Francesco: 1 article (07/2012)
5. Spurr, Ian B: 1 article (07/2012)
6. Tavassoli, Ali: 1 article (07/2012)
7. Baggott, Joseph E: 1 article (03/2010)
8. Tamura, Tsunenobu: 1 article (03/2010)
9. Camici, Marcella: 1 article (02/2010)
10. Ipata, Piero Luigi: 1 article (02/2010)

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4. Neurologic Manifestations (Neurological Manifestations)
5. Neoplasms (Cancer)

Related Drugs and Biologics

1. Methotrexate (Mexate)
2. purine
3. dihydrofolate
4. Phosphoribosylaminoimidazolecarboxamide Formyltransferase
5. IMP cyclohydrolase
6. Phosphoribosylglycinamide Formyltransferase
7. 3-Deazauridine (3 Deazauridine)
8. Tetrahydrofolate Dehydrogenase (Dihydrofolate Reductase)
9. Oxidoreductases (Dehydrogenase)
10. Nucleotides

Related Therapies and Procedures

1. Therapeutics