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Apoptosis Regulatory Proteins

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A large group of proteins that control APOPTOSIS. This family of proteins includes many ONCOGENE PROTEINS as well as a wide variety of classes of INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS such as CASPASES.

Also Known As:

Apoptosis Inducing Proteins; Apoptosis Inhibiting Proteins; Death Factors (Apoptosis); Programmed Cell Death Proteins; Survival Factors (Apoptosis); Regulatory Proteins, Apoptosis; Anti-Apoptotic Proteins; Pro-Apoptotic Proteins

Networked: 520 relevant articles (13 outcomes, 59 trials/studies)

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Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins
- Proteins: 90489
  - Intracellular Signaling Peptides and Proteins: 22
    - Apoptosis Regulatory Proteins: 520
- Peptides: 22950
  - Intracellular Signaling Peptides and Proteins: 22
    - Apoptosis Regulatory Proteins: 520

Experts

1.	Delivoria-Papadopoulos, Maria: 6 articles (07/2010 - 12/2003)
2.	Yoshida, H: 6 articles (11/2001 - 06/2001)
3.	Ogita, S: 6 articles (11/2001 - 06/2001)
4.	Ishiko, O: 6 articles (11/2001 - 06/2001)
5.	Sumi, T: 6 articles (11/2001 - 06/2001)
6.	Mishra, Om P: 4 articles (07/2010 - 12/2003)
7.	Hyun, Y: 4 articles (11/2001 - 07/2001)
8.	Katiyar, Santosh K: 3 articles (11/2015 - 01/2011)
9.	Shoshan-Barmatz, Varda: 3 articles (10/2015 - 06/2009)
10.	Hersey, Peter: 3 articles (08/2015 - 10/2003)

Related Diseases

1.	Neoplasms (Cancer) 09/01/2001 - "In this study, we investigated expressions of apoptosis regulatory proteins in the skeletal muscle of tumor-bearing and diet-restricted rabbits, and tried to evaluate the differences between the two groups. " 06/01/2001 - "In the present study, we investigated the expression of apoptosis regulatory proteins in advanced cervical cancer treated by cyclic BOAI. " 05/01/2001 - "A working hypothesis has been proposed to aid in the study of the mechanism by which the embryonic apoptosis-inducing proteins selectively induced apoptosis in cancer without affecting normal cells. " 09/01/2015 - "Most importantly, its high sensitivity to IP3 makes IP3R2 a target for anti-apoptotic proteins (e.g. Bcl-2) in B-cell cancers. " 06/01/2015 - "CAM-DR in tumor cells has been correlated with elevated expression of the nuclear anti-apoptotic proteins Bcl-2 and Bcl-XL. "
2.	Lymphoma (Lymphomas) 02/14/2015 - "B7-H3 overexpression improved Jak2 and STAT3 phosphorylation and, in turn, increased the expression of the downstream anti-apoptotic proteins B-cell CLL/lymphoma 2 (Bcl-2) and Bcl-xl, based on western blotting (P < 0.05). " 09/01/2013 - "Our data suggest that CFZ is able to overcome resistance to chemotherapeutic agents, upregulate pro-apoptotic proteins to promote apoptosis, and induce G2/M cell cycle arrest in lymphoma cells. " 06/01/2012 - "This effect was associated with a decrease in the production of the anti-apoptotic proteins, B cell leukaemia/lymphoma 2 (BCL2) and myeloid cell leukaemia sequence 1 (MCL1). " 01/01/2012 - "The B-cell CLL/lymphoma 2 (BCL2) gene family encodes pro- and anti-apoptotic proteins that are critical regulators of programmed cell death. " 04/01/2010 - "In order to survive, lymphoma cells depend on disruption of the apoptosis pathway by mutations in apoptosis inducing genes or by continuous expression of anti-apoptotic proteins. "
3.	Glioblastoma (Glioblastoma Multiforme) 09/01/2005 - "These studies demonstrate that modulation of levels of the anti-apoptotic proteins, Bcl-xL and Bcl-2, may enhance the sensitivity of glioblastoma toward chemotherapy." 12/01/1999 - "In vitro studies indicate a role of apoptosis regulatory proteins of the BCL-2 family in the resistance of glioblastoma multiforme to irradiation and chemotherapy. " 09/01/2005 - "Glioblastomas have developed effective mechanisms to resist chemotherapy including levels anti-apoptotic proteins, Bcl-xL and Bcl-2. " 08/01/2010 - "Studies regarding the regulatory process of apoptosis in glioblastoma (GBM), the most common malignant glioma, are few, and better knowledge of the expression of pro and anti-apoptotic proteins could collaborate with the development of new treatments founded on molecular basis. " 04/01/2001 - "We have analyzed the expression of the anti-apoptotic proteins bcl-2, bcl-xl and that of bax, a pro-apoptotic protein, in human WHO grade II astrocytomas (LGA) and WHO grade IV glioblastoma multiforme (GBM). "
4.	Glioma (Gliomas) 11/01/2011 - "We analyzed B-cell leukemia-2 (Bcl-2) anti-apoptotic proteins in GBM and found myeloid cell leukemia-1 (Mcl-1) to be the highest expressed in the majority of malignant gliomas. " 07/01/2004 - "Mechanisms that control expression of the anti-apoptotic proteins Bcl-xL and/or Bcl-2 may be effective targets in treatment strategies in patients with malignant gliomas." 04/01/1998 - "Therefore, PPF might promote apoptotic cell death through the mechanism that restore the glioma cells to the appropriate balance of proapoptotic and anti-apoptotic proteins like as normal astrocytes. " 04/01/1998 - "Glioma cell sensitivity to CD95-mediated apoptosis is regulated by CD95 expression at the cell surface and by the levels of intracellular apoptosis-regulatory proteins, including bcl-2 family members. " 08/01/2010 - "Studies regarding the regulatory process of apoptosis in glioblastoma (GBM), the most common malignant glioma, are few, and better knowledge of the expression of pro and anti-apoptotic proteins could collaborate with the development of new treatments founded on molecular basis. "
5.	Osteosarcoma (Osteogenic Sarcoma) 04/20/2011 - "In vitro, ERK1/2 blockage increased the expression of pro-apoptotic proteins and increased cell death in 143B osteosarcoma cells. " 12/15/2008 - "CDK inhibitors dramatically reduced levels of the anti-apoptotic proteins, Mcl-1 and XIAP, but siRNA-mediated suppression of Mcl-1 and XIAP did not induce cell death in the osteosarcoma cells used in this study. " 08/01/2010 - "The stronger staining of Bcl-2 and Mcl-1 proteins was also observed, while the staining of pro-apoptotic proteins (Bim and Bik) was significantly weaker or not detected in osteosarcoma tissues. " 01/01/2012 - "We propose that rhBMP-2 has great therapeutic potential in bone marrow cells by serving as a tumor suppressor to increase p53 and the pro-apoptotic proteins Bad and Bax, as well as by increasing the activity of phosphorylated caspase 3. Canine bone marrow mesenchymal stem cells associated with rhBMP2 in canine osteosarcoma treatment: "in vitro" study." 07/21/2015 - "Exposure of osteosarcoma cells to PPI caused an inactivation of the intrinsic nuclear factor κB (NF-κB) and activation of unfolded protein response (UPR)/endoplasmic reticulum (ER) stress signaling cascade in osteosarcoma cells, followed by down-regulation of anti-apoptotic proteins, with up-regulation of pro-apoptotic proteins. "

Related Drugs and Biologics

1.	Apoptosis Regulatory Proteins
2.	Proteins (Proteins, Gene)
3.	Caspase 8 (Caspase-8)
4.	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)
5.	Enzymes
6.	Caspases
7.	Small Interfering RNA (siRNA)
8.	ATP-Binding Cassette Transporters (ABC Transporters)
9.	Cladribine
10.	Tumor Suppressor Protein p53

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Resuscitation
3.	Radiotherapy
4.	Heterologous Transplantation (Xenotransplantation)
5.	Therapeutics