GATA5 Transcription Factor

A GATA transcription factor that is expressed predominately in SMOOTH MUSCLE CELLS and is involved in the CELL DIFFERENTIATION of CARDIAC MYOCYTES. In the developing heart, GATA5 becomes restricted to the ENDOCARDIUM and regulates transcription of genes such as cardiac TROPONIN C.

Also Known As:

Networked: 8 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Yan, Bo: 2 articles (01/2021 - 06/2020)
2.	Dong, Y: 1 article (01/2022)
3.	Ji, Wenfei: 1 article (01/2022)
4.	Jin, J-Y: 1 article (01/2022)
5.	Pi, H-C: 1 article (01/2022)
6.	Wu, H-F: 1 article (01/2022)
7.	Wu, L-P: 1 article (01/2022)
8.	Xiang, R: 1 article (01/2022)
9.	Zhang, Lili: 1 article (01/2022)
10.	Zhu, Hongjun: 1 article (01/2022)

Related Diseases

1.	Colorectal Neoplasms (Colorectal Cancer) 02/01/2015 - "Previously, we identified N-Myc downstream-regulated gene 4 (NDRG4) and GATA binding protein 5 (GATA5) methylation as promising biomarkers for colorectal cancer in stool DNA. "
2.	Tetralogy of Fallot (Fallot Tetralogy) 01/01/2022 - "Identification of a novel GATA binding protein 5 variant (c.830C>T/p.P277L) damaging the nuclear translocation and causing tetralogy of Fallot."
3.	Melanoma (Melanoma, Malignant) 08/01/2010 - "MS-LAMP was used for the highly specific detection of hypermethylated CpGs in the promoters of the CDKN2A [cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)], GATA5 (GATA binding protein 5), and DAPK1 (death-associated protein kinase 1) genes. "
4.	Leukemia 01/01/2018 - "Approach and Results- We screened various combinations of transcription factors, including Myocd (myocardin), Mef2C (myocyte enhancer factor 2C), Mef2B (myocyte enhancer factor 2B), Mkl1 (MKL [megakaryoblastic leukemia]/Myocd-like 1), Gata4 (GATA-binding protein 4), Gata5 (GATA-binding protein 5), Gata6 (GATA-binding protein 6), Ets1 (E26 avian leukemia oncogene 1, 5' domain), and their corresponding carboxyterminal fusions to the transactivation domain of MyoD (myogenic differentiation 1)-indicated by *-for their effects on reprogramming mouse embryonic fibroblasts and human adult dermal fibroblasts to the smooth muscle cell fate as determined by the expression of specific markers. "
5.	Inflammation (Inflammations) 01/01/2021 - "GATA binding protein 5 (GATA5) is an important member of GATA family and plays an important role in vascular inflammation, endothelial function, oxidative stress and cell metabolism. "

Related Drugs and Biologics

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3.	GATA Transcription Factors
4.	Collagen Type IX
5.	GTP Phosphohydrolases (GTPases)
6.	Cyclin-Dependent Kinase Inhibitor p16
7.	Biomarkers (Surrogate Marker)
8.	Transcription Factors (Transcription Factor)
9.	Retinaldehyde (Retinal)
10.	Laminin (Merosin)