NF-E2 Transcription Factor

A basic-leucine zipper transcription factor that regulates GLOBIN gene expression and is related to TRANSCRIPTION FACTOR AP-1. NF-E2 consists of a small MAF protein subunit and a tissue-restricted 45 kDa subunit.

Also Known As:

NFE2 Transcription Factor; Nuclear Factor-Erythroid 2 Transcription Factor; Factor, NFE2 Transcription; NF E2 Transcription Factor; Nuclear Factor Erythroid 2 Transcription Factor; Transcription Factor, NF-E2; Transcription Factor, NFE2

Networked: 26 relevant articles (1 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Pahl, Heike L: 5 articles (01/2020 - 07/2010)
2.	Aumann, Konrad: 3 articles (01/2016 - 01/2012)
3.	Werner, Martin: 3 articles (01/2016 - 01/2012)
4.	Kensler, Thomas W: 2 articles (08/2020 - 01/2019)
5.	Gründer, Albert: 2 articles (01/2020 - 01/2012)
6.	Schwemmers, Sven: 2 articles (01/2020 - 07/2010)
7.	Wehrle, Julius: 2 articles (01/2020 - 01/2012)
8.	Dinkova-Kostova, Albena T: 2 articles (01/2019 - 09/2014)
9.	Hayes, John D: 2 articles (01/2019 - 09/2014)
10.	Barati, Michelle T: 1 article (02/2022)

Related Diseases

1.	Reperfusion Injury 07/15/2013 - "Activation of the redox-sensitive transcription factor NF-E2 related factor 2 (Nrf2) affords protection against cerebral ischaemia-reperfusion injury via the upregulation of antioxidant defence genes. "
2.	Thrombocytopenia (Thrombopenia) 08/15/2000 - "Mice lacking the transcription factor NF-E2 show profound thrombocytopenia, and their megakaryocytes fail to produce proplatelets, the microtubule-based precursors of blood platelets. " 09/01/1998 - "Mice lacking transcription factor NF-E2 have a late arrest in megakaryocyte maturation, resulting in profound thrombocytopenia. " 03/27/1998 - "Mice lacking the transcription factor NF-E2 display arrested megakaryocyte differentiation and profound thrombocytopenia. " 11/01/1999 - "Pathophysiology of thrombocytopenia and anemia in mice lacking transcription factor NF-E2."
3.	Acute Erythroblastic Leukemia (Erythroleukemia) 01/01/2006 - "The function of the NF-E2 transcription factor, a p45/small Maf heterodimer, was analyzed in the erythroleukemia cell lines MEL and CB3. " 08/30/1994 - "Retroviral integration within the Fli-2 locus results in inactivation of the erythroid transcription factor NF-E2 in Friend erythroleukemias: evidence that NF-E2 is essential for globin expression." 01/01/2006 - "Regulation of globin gene transcription by heme in erythroleukemia cells: analysis of putative heme regulatory motifs in the p45 NF-E2 transcription factor." 08/01/1995 - "Using antisense technology, the effects of suppressed gene expression of the erythroid-specific delta-aminolevulinate (ALA) synthase (ALAS-E) on heme synthesis, expression of mRNAs encoding an erythroid-specific transcription factor NF-E2, other heme pathway enzymes, and beta-globin were examined in murine erythroleukemia (MEL) cells. " 05/01/1998 - "Activation of cyclic adenosine monophosphate (cAMP)-dependent protein kinase (A-kinase) promotes hemoglobin synthesis in several erythropoietin-dependent cell lines, whereas A-kinase-deficient murine erythroleukemia (MEL) cells show impaired hemoglobin production; A-kinase may regulate the erythroid transcription factor NF-E2 by directly phosphorylating its p45 subunit or by changing p45 interactions with other proteins. "
4.	Neoplasms (Cancer) 01/01/2023 - "The transcription factor NFE2 is overexpressed in most patients with myeloproliferative neoplasms (MPN). " 01/01/2020 - "Activity of the transcription factor NFE2 is elevated in the majority of patients with myeloproliferative neoplasms (MPNs), either by overexpression of the wild-type alleles or by the presence of an activating mutation. " 02/01/2014 - "A novel murine model for myeloproliferative neoplasms (MPNs) generated by overexpression of the transcription factor NF-E2 has recently been described. "
5.	Inflammation (Inflammations) 02/06/2022 - "The transcription factor NF-E2 related factor 2 (Nrf2) is a central regulator of cellular anti-oxidative responses, inflammation, and restoration of redox balance. " 08/07/2020 - "The transcription factor NF-E2 p45-related factor 2 (NRF2; encoded by NFE2L2) plays a critical role in the maintenance of cellular redox and metabolic homeostasis, as well as the regulation of inflammation and cellular detoxication pathways. " 01/01/2019 - "The transcription factor NF-E2 p45-related factor 2 (NRF2; encoded by NFE2L2) and its principal negative regulator, the E3 ligase adaptor Kelch-like ECH-associated protein 1 (KEAP1), are critical in the maintenance of redox, metabolic and protein homeostasis, as well as the regulation of inflammation. "

Related Drugs and Biologics

1.	Antioxidants
2.	beta-Globins (beta Globin)
3.	Proteins (Proteins, Gene)
4.	NAD (NADH)
5.	Heme (Haem)
6.	Globins
7.	quinone (benzoquinone)
8.	alpha-Globins
9.	Ubiquitin-Protein Ligases (Ubiquitin-Protein Ligase)
10.	Pulmonary Surfactant-Associated Protein D (Surfactant Protein D)