Basic-Leucine Zipper Transcription Factors

A large superfamily of transcription factors that contain a region rich in BASIC AMINO ACID residues followed by a LEUCINE ZIPPER domain.

Also Known As:

GBF bZIP Transcription Factors; bZIP Proteins; bZIP Transcription Factors; Basic Leucine Zipper Transcription Factor; Basic Leucine Zipper Transcription Factors; Factor, bZIP Transcription; Protein, bZIP; Transcription Factor, bZIP; Transcription Factors, bZIP; bZIP G Box Binding Factor; bZIP G Box Binding Factors; Basic-Leucine Zipper Transcription Factor; GBF bZIP Transcription Factor; bZIP G-Box Binding Factor; bZIP G-Box Binding Factors; bZIP Protein; bZIP Transcription Factor

Networked: 187 relevant articles (3 outcomes, 11 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Transcription Factors: 38804
    - Basic-Leucine Zipper Transcription Factors: 187
  - DNA-Binding Proteins: 2009
    - Basic-Leucine Zipper Transcription Factors: 187

Experts

1.	Yamamoto, Masayuki: 5 articles (01/2021 - 04/2006)
2.	Mesnard, Jean-Michel: 3 articles (08/2008 - 12/2002)
3.	Nishizawa, Naoko K: 2 articles (01/2022 - 02/2010)
4.	Izumiya, Yoshihiro: 2 articles (12/2021 - 02/2010)
5.	Adams, Christopher M: 2 articles (01/2020 - 05/2017)
6.	Ebert, Scott M: 2 articles (01/2020 - 05/2017)
7.	Haynes, Cole M: 2 articles (01/2019 - 01/2012)
8.	Smart, Robert C: 2 articles (10/2018 - 02/2005)
9.	Brakhage, Axel A: 2 articles (10/2018 - 05/2017)
10.	Haas, Hubertus: 2 articles (10/2018 - 05/2017)

Related Diseases

1.	Neoplasms (Cancer) 11/01/2023 - "In this review, we recount the evidence identifying the basic leucine zipper transcription factors ATF5, CEBPB, and CEBPD as targets for brain and other malignancies. " 09/01/2022 - "Basic leucine zipper transcription factor ATF-like 3 (BATF3) plays a key role in tumor immunity. " 05/29/2020 - "MafF is a member of the basic leucine zipper (bZIP) transcription factor Maf family and is commonly downregulated in multiple cancers. " 01/01/2020 - "The basic leucine zipper transcription factor ATF-like 3 (BATF3) is required for the development of conventional type 1 dendritic cells that are essential for cross-presentation and CD8 T cell-mediated immunity against intracellular pathogens and tumors. " 01/01/2020 - "The basic leucine zipper transcription factor ATF5 is overexpressed in many tumor types and interference with its expression or function inhibits cancer cell survival. "
2.	Starvation 02/13/2015 - "In this study we observed that bZIP transcription factor AtTGA4 (TGACG motif-binding factor 4) was induced by both drought and low nitrogen stresses, and that overexpression of AtTGA4 simultaneously improved drought resistance and reduced nitrogen starvation in Arabidopsis. " 05/01/2019 - "Studies have indicated that the carbon starvation response leads to the reprogramming of the transcriptome and metabolome, and many genes, including several important regulators, such as the group S1 basic leucine zipper transcription factors (TFs) bZIP1, bZIP11 and bZIP53, the SNAC-A TF ATAF1, etc., are involved in these physiological processes. " 10/01/2018 - "Moreover, simultaneous inactivation of LeuB and HapX, a bZIP transcription factor required for adaptation to iron starvation, significantly aggravated the growth defect caused by inactivation of one of these regulators during iron starvation. " 01/01/2018 - "Here, we showed that the bZip transcription factor VdHapX functions as a key regulator of iron homeostasis for adaptation to iron-depleted and iron-excess conditions and is required for full virulence in the vascular wilt fungus, Verticillium dahliae Deletion of VdHapX impaired mycelial growth and conidiation under both iron starvation and iron sufficiency. " 05/01/2017 - "Moreover, via interaction with the iron-sensing bZIP transcription factor HapX, the CBC was shown to mediate adaptation to both iron starvation and iron excess. "
3.	Infections 03/01/2022 - "Taken together, our findings reveal that bZIP transcription factors function as key regulators of fungal morphogenesis, abiotic stress response and pathogenesis, and expand our understanding of how microbial pathogens utilize these genes to deal with environmental stresses and achieve successful infection in the host plant." 12/01/2021 - "Here, we report that Maf bZIP transcription factor F (MafF) promotes host defense against infection with HBV. " 06/25/2021 - "The bZIP transcription factor GmbZIP15 facilitates resistance against Sclerotinia sclerotiorum and Phytophthora sojae infection in soybean." 01/01/2021 - "Based on a transcriptome profiling of the nematode Caenorhabditis elegans, we found that a bZIP transcription factor ZIP-11 was up-regulated upon Pseudomonas aeruginosa PA14 infection. " 04/19/2012 - "Upon infection with pathogenic Pseudomonas aeruginosa, the nematode C. elegans upregulates infection response gene irg-1 using the zip-2 bZIP transcription factor. "
4.	Fibrosarcoma 01/01/2022 - "In this study, we report that a basic leucine zipper (bZip) transcription factor v-maf musculoaponeurotic fibrosarcoma oncogene homolog B (MafB) suppresses the induction of type I IFNs in pDCs. " 03/01/2015 - "Under normal conditions, the -44-kb ARE is occupied by the repressor BTB and CNC homology 1, basic leucine zipper transcription factor (Bach1), and v-Maf avian musculoaponeurotic fibrosarcoma oncogene homolog K (MafK) heterodimers. " 03/01/2020 - "Nuclear factor erythroid 2-related factor 2 (Nrf2) is a member of a family of CNC-bZIP proteins which exert their transcriptional control on genes harboring antioxidant response elements (ARE) in partnership with small musculoaponeurotic fibrosarcoma proteins. " 06/01/2017 - "Ectopic expression of musculo aponeurotic fibrosarcoma BZIP transcription factor (Maf) A, has previously been demonstrated to induce insulin expression in non‑β‑cell lines. " 03/30/2012 - "We found that a constitutively active form of STAT5 effectively inhibited Tfh differentiation by suppressing the expression of Tfh-associated factors (CXC motif) receptor 5 (CXCR5), musculoaponeurotic fibrosarcoma (c-Maf), Bcl6, basic leucine zipper transcription factor ATF-like (Batf), and IL-21, and STAT5 deficiency greatly enhanced Tfh gene expression. "
5.	Carcinogenesis 08/01/2013 - "Meq, a bZIP transcription factor discovered in the 1990s, is critically involved in viral oncogenicity, but only a few of its host target genes have been described, impeding our understanding of MDV-induced tumorigenesis. " 01/01/2013 - "MDV mEq, a bZIP transcription factor, is largely attributed to viral oncogenicity though only a few host target genes have been described, which has impeded our understanding of MDV-induced tumorigenesis. " 01/01/2005 - "Members of the Maf protooncogene and cap'n' collar families of basic-leucine zipper transcription factors play important roles in development, differentiation, oncogenesis, and stress signaling. " 04/01/2008 - "We examine the role of ATF-2 in carcinogenesis with respect to other bZIP proteins, using data from studies in human cancer cell lines, human tumours and mouse models, and we propose a potential model for its function in carcinogenesis, as well as a theoretical basis for its utility in anticancer drug design." 11/01/2008 - "CREB is a prototypic bZIP transcription factor and a master regulator of glucose metabolism, synaptic plasticity, cell growth, apoptosis, and tumorigenesis. "

Related Drugs and Biologics

1.	Isoflavones
2.	Nitrogen
3.	Proteins (Proteins, Gene)
4.	Peroxidases
5.	Kainic Acid (Kainate)
6.	Carbon
7.	Transcription Factors (Transcription Factor)
8.	Phosphotransferases (Kinase)
9.	DNA (Deoxyribonucleic Acid)
10.	CCAAT-Enhancer-Binding Proteins

Related Therapies and Procedures

1.	Transplantation
2.	Punctures
3.	Ligation