Aminomethyltransferase (Glycine Synthase)

A one-carbon group transferase that transfers lipoamide-linked methylamine groups to tetrahydrofolate (TETRAHYDROFOLATES) to form methylenetetrahydrofolate and AMMONIA. It is one of four components of the glycine decarboxylase complex.

Also Known As:

Glycine Synthase; Glycine Decarboxylase Complex T-Protein; T-Protein, Glycine Cleavage System; Tetrahydrofolate Aminomethyltransferase; Aminomethyltransferase, Tetrahydrofolate; Glycine Decarboxylase Complex T Protein; Synthase, Glycine; T Protein, Glycine Cleavage System

Networked: 12 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Applegarth, D A: 2 articles (04/2001 - 01/2001)
2.	Coulter-Mackie, M B: 2 articles (04/2001 - 01/2001)
3.	James, E R: 2 articles (04/2001 - 01/2001)
4.	Toone, J R: 2 articles (04/2001 - 01/2001)
5.	Breen, M: 2 articles (03/2000 - 01/2000)
6.	Brenig, B: 2 articles (03/2000 - 01/2000)
7.	Leeb, T: 2 articles (03/2000 - 01/2000)
8.	Copp, Andrew J: 1 article (01/2021)
9.	De Castro, Sandra C P: 1 article (01/2021)
10.	Galea, Gabriel L: 1 article (01/2021)

Related Diseases

1.	Nonketotic Hyperglycinemia 09/01/2018 - "Identification of Two Novel Mutations in Aminomethyltransferase Gene in Cases of Glycine Encephalopathy." 01/01/2021 - "Mutation of AMT or GLDC, encoding the GCS components aminomethyltransferase and glycine decarboxylase, can cause malformations of the developing CNS (neural tube defects (NTDs) and ventriculomegaly) as well as a post-natal life-limiting neurometabolic disorder, Non-Ketotic Hyperglycinemia. " 01/01/2001 - "Identification of the first reported splice site mutation (IVS7-1G-->A) in the aminomethyltransferase (T-protein) gene (AMT) of the glycine cleavage complex in 3 unrelated families with nonketotic hyperglycinemia." 11/01/2014 - "Mutation analysis of glycine decarboxylase, aminomethyltransferase and glycine cleavage system protein-H genes in 13 unrelated families with glycine encephalopathy." 04/01/2001 - "Screening a DNA bank from 50 patients with enzymatic confirmation of their diagnosis of nonketotic hyperglycinemia gave allele frequencies of 5% for R515S of P-protein (glycine decarboxylase) and 7% for R320H of T-protein (aminomethyltransferase). "
2.	T-Cell Leukemia (Leukemia, T Cell) 01/01/2000 - "The two genes represent the corresponding canine orthologs of human aminomethyltransferase (AMT) and the human T-cell leukemia translocation associated (TCTA) gene. " 03/01/2000 - "The analysis of the entire reported sequence revealed that the genes for aminomethyltransferase (AMT), bassoon (BSN), TCTA (T-cell leukemia translocation-associated) gene, and an as yet uncharacterized protein are located very close to the DAG1 gene. "
3.	Disease Progression 01/01/2023 - "Our work suggests that dysregulation of vascular smooth muscle cell metabolism participates in phenotypic transitioning, which may contribute to disease progression, and suggests that AMT (aminomethyltransferase) and MPI (mannose phosphate isomerase) may play an important role in regulating nitrogen and glycolysis-related metabolism in smooth muscle cells."
4.	Vitamin B 12 Deficiency (Vitamin B12 Deficiency) 10/01/1975 - "The activity of the glycine synthase system was reduced during vitamin B12 deficiency to 25% of control activity. "
5.	Obesity 10/01/2020 - "Obesity increases hepatic glycine dehydrogenase and aminomethyltransferase expression while dietary glycine supplementation reduces white adipose tissue in Zucker diabetic fatty rats."

Related Drugs and Biologics

1.	Proteins (Proteins, Gene)
2.	Glycine Dehydrogenase (Decarboxylating)
3.	Glycine (Aminoacetic Acid)
4.	Enzymes
5.	Glycine Dehydrogenase
6.	A-Form DNA (A-DNA)
7.	Guanine Nucleotide Dissociation Inhibitors (GDIs)
8.	Phosphates (Orthophosphate)
9.	Oxidoreductases (Dehydrogenase)
10.	Nitrogen