Betaine-Homocysteine S-Methyltransferase (Betaine Homocysteine Methyltransferase)

A ZINC metalloenzyme that catalyzes the transfer of a methyl group from BETAINE to HOMOCYSTEINE to produce dimethylglycine and METHIONINE, respectively. This enzyme is a member of a family of ZINC-dependent METHYLTRANSFERASES that use THIOLS or selenols as methyl acceptors.

Also Known As:

Betaine Homocysteine Methyltransferase; Methyltransferase, Betaine Homocysteine; Bet-HCys MTase; Betaine-Homocysteine Methyltransferase; Betaine-Homocysteine Methyltransferase 2; Betaine-Homocysteine Methyltransferase-2; Bet HCys MTase; Betaine Homocysteine Methyltransferase 2; Betaine Homocysteine S Methyltransferase; Homocysteine Methyltransferase, Betaine; MTase, Bet-HCys; Methyltransferase 2, Betaine-Homocysteine; Methyltransferase, Betaine-Homocysteine; Methyltransferase-2, Betaine-Homocysteine; S-Methyltransferase, Betaine-Homocysteine

Networked: 62 relevant articles (1 outcomes, 4 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Transferases: 6589
    - One-Carbon Group Transferases
      - Methyltransferases: 5778
        Betaine-Homocysteine S-Methyltransferase: 62
        human BHMT protein
        human BHMT2 protein
        mouse Bhmt protein
        mouse Bhmt2 protein
        rat Bhmt protein

Experts

1.	Garrow, Timothy A: 7 articles (10/2011 - 04/2003)
2.	Zeisel, Steven H: 5 articles (01/2019 - 07/2006)
3.	Schalinske, Kevin L: 4 articles (01/2019 - 11/2004)
4.	Sugiyama, Kimio: 3 articles (01/2014 - 12/2008)
5.	Neuman, Joshua C: 2 articles (01/2019 - 06/2013)
6.	Teng, Ya-Wen: 2 articles (11/2012 - 10/2011)
7.	Alberto, Jean-Marc: 2 articles (02/2012 - 08/2007)
8.	Bronowicki, Jean-Pierre: 2 articles (02/2012 - 08/2007)
9.	Guéant, Jean-Louis: 2 articles (02/2012 - 08/2007)
10.	Morita, Tatsuya: 2 articles (01/2012 - 12/2008)

Related Diseases

1.	Homocystinuria 05/01/2004 - "Glycine betaine supplementation lowers homocysteine levels in homocystinuria and in chronic renal failure patients through methylation catalysed by betaine-homocysteine methyltransferase (BHMT). " 01/01/2019 - "Taurine alleviates repression of betaine-homocysteine S-methyltransferase and significantly improves the efficacy of long-term betaine treatment in a mouse model of cystathionine β-synthase-deficient homocystinuria." 01/01/2019 - "Taurine alleviates repression of betaine-homocysteine S-methyltransferase and significantly improves the efficacy of long-term betaine treatment in a mouse model of cystathionine β-synthase-deficient homocystinuria." 08/01/2007 - "We showed that CBS deficiency in mice reduced hepatic methionine synthase and betaine-homocysteine methyltransferase activities, whereas 5,10-methylene tetrahydrofolate reductase activity was increased."
2.	Hyperhomocysteinemia 06/01/2006 - "Inhibition of betaine-homocysteine S-methyltransferase causes hyperhomocysteinemia in mice." 01/01/2019 - "A., Varela-Moreiras, G., Varela-Nieto, I. Betaine-homocysteine S-methyltransferase deficiency causes increased susceptibility to noise-induced hearing loss associated with plasma hyperhomocysteinemia." 01/01/2019 - "Betaine-homocysteine S-methyltransferase deficiency causes increased susceptibility to noise-induced hearing loss associated with plasma hyperhomocysteinemia." 11/01/2000 - "Betaine-homocysteine methyltransferase (BHMT): genomic sequencing and relevance to hyperhomocysteinemia and vascular disease in humans." 08/01/2013 - "Effects of hyperhomocysteinemia and betaine-homocysteine S-methyltransferase inhibition on hepatocyte metabolites and the proteome."
3.	Hepatocellular Carcinoma (Hepatoma) 05/01/2016 - "Downregulation of betaine homocysteine methyltransferase (BHMT) in hepatocellular carcinoma associates with poor prognosis." 02/01/2012 - "A splicing variant leads to complete loss of function of betaine-homocysteine methyltransferase (BHMT) gene in hepatocellular carcinoma." 04/01/2007 - "Osmotic regulation of betaine homocysteine-S-methyltransferase expression in H4IIE rat hepatoma cells." 10/21/2011 - "Deletion of betaine-homocysteine S-methyltransferase in mice perturbs choline and 1-carbon metabolism, resulting in fatty liver and hepatocellular carcinomas." 04/15/2006 - "We have previously reported a positive correlation between the expression of BHMT (betaine-homocysteine S-methyltransferase) and ApoB (apolipoprotein B) in rat hepatoma McA (McArdle RH-7777) cells [Sowden, Collins, Smith, Garrow, Sparks and Sparks (1999) Biochem. "
4.	Spinal Dysraphism (Spina Bifida) 06/15/2005 - "Are the betaine-homocysteine methyltransferase (BHMT and BHMT2) genes risk factors for spina bifida and orofacial clefts?" 06/01/2003 - "Common variant in betaine-homocysteine methyltransferase (BHMT) and risk for spina bifida." 06/15/2005 - "The goal of our study was to investigate sequence variations in the betaine-homocysteine methyltransferase (BHMT) and betaine-homocysteine methyltransferase (BHMT2) genes as modifiers of risk of spina bifida, cleft palate, and cleft lip and palate. "
5.	Cleft Palate (Palate, Cleft) 06/15/2005 - "The goal of our study was to investigate sequence variations in the betaine-homocysteine methyltransferase (BHMT) and betaine-homocysteine methyltransferase (BHMT2) genes as modifiers of risk of spina bifida, cleft palate, and cleft lip and palate. " 06/01/2011 - "As genetic variants in folate and homocysteine metabolism have been reported to influence the risk of orofacial clefts, an Italian cleft lip with or without cleft palate (CL/P) data set was enrolled for an analysis based on family association to test betaine-homocysteine methyltransferase (BHMT and BHMT2) and cystathionine beta-synthase (CBS) variants. "

Related Drugs and Biologics

1.	Cystathionine
2.	Betaine (C.B.B.)
3.	Taurine
4.	Homocysteine
5.	Folic Acid (Vitamin M)
6.	Choline (Choline Chloride)
7.	Messenger RNA (mRNA)
8.	Complementary DNA (cDNA)
9.	Nylons (Nylon)
10.	Egg Proteins