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Phosphatidylethanolamine N-Methyltransferase

An enzyme that catalyses three sequential METHYLATION reactions for conversion of phosphatidylethanolamine to PHOSPHATIDYLCHOLINE.
Also Known As:
Cephalin N-Methyltransferase; PHET Methyltransferase II; Phosphatidylethanolamine Methyltransferase; Phosphatidylethanolamine N-Methyltransferase-2; Phosphatidylethanolamine-Methyltransferase II; Phosphatidylethanolamine-Phosphatidylcholine N-Methyltransferase; Phospholipid Methyltransferase II; S-Adenosylmethionine Phosphatidylethanolamine N-Methyltransferase; Cephalin N Methyltransferase; Methyltransferase II, PHET; Methyltransferase II, Phospholipid; Methyltransferase, Phosphatidylethanolamine; N-Methyltransferase, Cephalin; N-Methyltransferase, Phosphatidylethanolamine; N-Methyltransferase, Phosphatidylethanolamine-Phosphatidylcholine; N-Methyltransferase, S-Adenosylmethionine Phosphatidylethanolamine; N-Methyltransferase-2, Phosphatidylethanolamine; Phosphatidylethanolamine Methyltransferase II; Phosphatidylethanolamine N Methyltransferase; Phosphatidylethanolamine N Methyltransferase 2; Phosphatidylethanolamine N-Methyltransferase, S-Adenosylmethionine; Phosphatidylethanolamine Phosphatidylcholine N Methyltransferase; S Adenosylmethionine Phosphatidylethanolamine N Methyltransferase
Networked: 61 relevant articles (1 outcomes, 1 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Vance, Dennis E: 15 articles (01/2019 - 01/2003)
2. Jacobs, René L: 10 articles (01/2017 - 01/2007)
3. van der Veen, Jelske N: 6 articles (01/2019 - 02/2015)
4. Lingrell, Susanne: 5 articles (01/2019 - 07/2010)
5. Gao, Xia: 5 articles (01/2017 - 02/2015)
6. Kassiri, Zamaneh: 3 articles (01/2019 - 01/2016)
7. Vance, Jean E: 3 articles (09/2015 - 04/2009)
8. Zhao, Yang: 3 articles (07/2010 - 02/2003)
9. Brosnan, John T: 3 articles (09/2009 - 02/2003)
10. Lieber, C S: 3 articles (11/2001 - 01/2000)

Related Diseases

1. Fibrosis (Cirrhosis)
06/01/1994 - "1. Alcohol consumption diminishes phosphatidylethanolamine N-methyltransferase activity prior to the development of cirrhosis and decreases the hepatic content of its product, namely phosphatidylcholine, a key component of cell membranes. "
08/18/2022 - "Reduced expression of hepatic phosphatidylethanolamine N-methyltransferase (PEMT), which catalyzes the production of phosphatidylcholine, causes steatosis, inflammation, and fibrosis in mice. "
01/01/2016 - "Pioglitazone attenuates hepatic inflammation and fibrosis in phosphatidylethanolamine N-methyltransferase-deficient mice."
01/03/1997 - "In addition, polyenylphosphatidylcholine (PPC) fully prevents ethanol-induced septal fibrosis and cirrhosis, opposes ethanol-induced hepatic phospholipid depletion, decreased phosphatidylethanolamine methyltransferase activity and activation of hepatic lipocytes, whereas its dilinoleoyl species increases collagenase activity. "
01/01/1994 - "Elucidation of the biochemical effects of ethanol are now resulting in improved therapy: in baboons, S-adenosyl-L-methionine attenuates the ethanol-induced glutathione depletion and associated mitochondrial lesions, and polyenylphosphatidylcholine opposes the ethanol-induced hepatic phospholipid depletion, the decrease in phosphatidylethanolamine methyltransferase activity and the activation of hepatic lipocytes, with full prevention of ethanol-induced septal fibrosis and cirrhosis; its dilinoleoyl species also increases collagenase activity in lipocytes. "
2. Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung)
3. Hepatocellular Carcinoma (Hepatoma)
4. Obesity
5. Non-alcoholic Fatty Liver Disease

Related Drugs and Biologics

1. Phospholipids (Phosphatides)
2. Collagenases (Collagenase)
3. S-Adenosylmethionine (Ademetionine)
4. Ethanol (Ethyl Alcohol)
5. lipostabil
6. Glutathione (Reduced Glutathione)
7. Choline (Choline Chloride)
8. Phosphatidylcholines (Phosphatidylcholine)
9. Enzymes
10. Phosphotransferases (Kinase)

Related Therapies and Procedures

1. Therapeutics
2. Hypophysectomy
3. Adrenalectomy