Nicotinamide N-Methyltransferase

An enzyme found primarily in the LIVER that catalyzes the N-methylation of NICOTINAMIDE and other structurally related compounds.

Also Known As:

Nicotinamide Methylase; Nicotinamide Methyltransferase; Nicotinamide-S-Adenosylmethionine Methyltransferase; Methylase, Nicotinamide; Methyltransferase, Nicotinamide; Methyltransferase, Nicotinamide-S-Adenosylmethionine; N-Methyltransferase, Nicotinamide; Nicotinamide N Methyltransferase; Nicotinamide S Adenosylmethionine Methyltransferase

Networked: 172 relevant articles (2 outcomes, 16 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Transferases: 6589
    - One-Carbon Group Transferases
      - Methyltransferases: 5778
        Nicotinamide N-Methyltransferase: 172
        C elegans ANMT-1 protein
        human NNMT protein
        mouse Nnmt protein
        rat Nnmt protein

Experts

1.	Emanuelli, Monica: 19 articles (11/2021 - 11/2006)
2.	Sartini, Davide: 19 articles (11/2021 - 11/2006)
3.	Pozzi, Valentina: 15 articles (11/2021 - 01/2010)
4.	Rubini, Corrado: 11 articles (04/2020 - 07/2007)
5.	Zhang, Jun: 9 articles (01/2022 - 02/2010)
6.	Santarelli, Andrea: 8 articles (10/2021 - 07/2007)
7.	Parsons, Richard B: 8 articles (04/2021 - 02/2002)
8.	Ramsden, David B: 7 articles (04/2021 - 02/2002)
9.	Wang, Yanzhong: 7 articles (01/2021 - 01/2014)
10.	Xie, Xinyou: 7 articles (01/2021 - 01/2014)

Related Diseases

1.	Neoplasms (Cancer) 11/01/2006 - "Additional studies may establish the role of nicotinamide N-methyltransferase in tumor formation and progression." 10/01/2022 - "Particularly high activity of nicotinamide N-methyltransferase is detected in liver, many neoplasms as well as in various cells in stressful conditions. " 01/01/2022 - "Complex roles of nicotinamide N-methyltransferase in cancer progression." 01/01/2022 - "Systematic pan-cancer analysis of the nicotinamide n-methyltransferase in human cancer." 01/01/2022 - "Prognostic value of nicotinamide N-methyltransferase in human cancers: Evidence from a meta-analysis and database validation."
2.	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 04/06/2022 - "Targeting nicotinamide N-methyltransferase overcomes resistance to EGFR-TKI in non-small cell lung cancer cells." 06/01/2018 - "Targeting Nicotinamide N-Methyltransferase and miR-449a in EGFR-TKI-Resistant Non-Small-Cell Lung Cancer Cells." 03/01/2015 - "Role of nicotinamide N-methyltransferase in non-small cell lung cancer: in vitro effect of shRNA-mediated gene silencing on tumourigenicity." 01/01/2013 - "Nicotinamide N-methyltransferase in non-small cell lung cancer: promising results for targeted anti-cancer therapy."
3.	Fibrosis (Cirrhosis) 01/01/2022 - "Nicotinamide N-methyltransferase ameliorates renal fibrosis by its metabolite 1-methylnicotinamide inhibiting the TGF-β1/Smad3 pathway." 01/01/2023 - "Nicotinamide N-methyltransferase (NNMT) has been found to increase in kidneys with TIF, but its role in renal fibrosis is unclear. " 01/01/2023 - "Nicotinamide N-methyltransferase (NNMT) has been shown to be associated with renal fibrosis. "
4.	Breast Neoplasms (Breast Cancer) 01/01/2023 - "Nicotinamide N-methyltransferase sustains a core epigenetic program that promotes metastatic colonization in breast cancer." 01/01/2020 - "Nicotinamide N-methyltransferase inhibits autophagy induced by oxidative stress through suppressing the AMPK pathway in breast cancer cells." 01/01/2014 - "Down-regulation of nicotinamide N-methyltransferase induces apoptosis in human breast cancer cells via the mitochondria-mediated pathway." 01/01/2023 - "Nicotinamide N-methyltransferase and DKK1 were linked to breast cancer malignancy and invasion. " 01/01/2023 - "Nicotinamide N-methyltransferase (NNMT) and Dickkopf-1 (DKK1) play an important role in the development of breast cancer, and the purpose of this study was designed to examine the clinical and prognostic significance of NNMT and DKK1 in breast cancer. "
5.	Ovarian Neoplasms (Ovarian Cancer) 02/01/2021 - "Nicotinamide N-methyltransferase overexpression may be associated with poor prognosis in ovarian cancer." 01/14/2021 - "The role of nicotinamide N-methyltransferase (NNMT) in ovarian cancer is still elusive. " 01/14/2021 - "Patients with low nicotinamide N-methyltransferase expression benefit significantly from bevacizumab treatment in ovarian cancer." 09/01/2021 - "Seminal proteomic studies in the area of ovarian cancer, such as the PROVAR and CPTA studies are discussed, along side recent research, such as that highlighting the central role of methyltransferase nicotinamide N-methyltransferase as the metabolic regulation of cancer progression in the tumour stroma. "

Related Drugs and Biologics

1.	N(1)-methylnicotinamide
2.	N-nitroso-N-methyltyramine (NNMT)
3.	Enzymes
4.	Niacinamide (Nicotinamide)
5.	Biomarkers (Surrogate Marker)
6.	Methyltransferases
7.	Small Interfering RNA (siRNA)
8.	2-(4-chlorophenylthio)triethylamine
9.	Proteins (Proteins, Gene)
10.	Xenobiotics

Related Therapies and Procedures

1.	Therapeutics
2.	Fat-Restricted Diet (Diet, Fat Restricted)
3.	Nephrectomy
4.	Drug Therapy (Chemotherapy)