Nitrate Reductase

An enzyme that catalyzes the oxidation of nitrite to nitrate. It is a cytochrome protein that contains IRON and MOLYBDENUM.

Also Known As:

Quinol-Nitrate Oxidoreductase; Respiratory Nitrate Reductase; Nitrate Reductase, Respiratory; Oxidoreductase, Quinol-Nitrate; Quinol Nitrate Oxidoreductase; Reductase, Nitrate; Reductase, Respiratory Nitrate

Networked: 173 relevant articles (5 outcomes, 14 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Oxidoreductases: 13671
    - Nitroreductases: 247
      - Nitrate Reductases: 3
        Nitrate Reductase: 173
        Arabidopsis NIA1 protein
        Arabidopsis NIA2 protein
        E coli napA protein
        E coli NarG protein
        E coli narZ protein

Experts

1.	Martin, Anandi: 6 articles (04/2014 - 04/2005)
2.	Palomino, Juan Carlos: 5 articles (02/2014 - 04/2005)
3.	Ahmad, Parvaiz: 3 articles (05/2022 - 06/2020)
4.	Affolabi, Dissou: 3 articles (01/2019 - 08/2008)
5.	Uzun, Meltem: 3 articles (01/2016 - 05/2011)
6.	Coban, Ahmet Yilmaz: 3 articles (08/2015 - 05/2011)
7.	Bwanga, Freddie: 3 articles (09/2013 - 05/2009)
8.	Hoffner, Sven: 3 articles (09/2013 - 05/2009)
9.	Kaya, Cengiz: 2 articles (06/2021 - 06/2020)
10.	Joloba, Moses: 2 articles (01/2019 - 09/2013)

Related Diseases

1.	Multiple Organ Failure (MODS) 05/09/2011 - "In this study we compared two direct techniques--Nitrate Reductase Assay (NRA) and Microscopic Observation Drug Susceptibility (MODS) for rapid detection of MDR-TB in a high burden RLS. " 08/01/2006 - "A study was carried out to compare the performance of a commercial method (MGIT) and four inexpensive drug susceptibility methods: nitrate reductase assay (NRA), microscopic observation drug susceptibility (MODS) assay, MTT test, and broth microdilution method (BMM). " 11/01/2018 - "To evaluate the association between rapid DST use (nitrate reductase assay, microscopic observation drug susceptibility assay [MODS] and GenoType® MTBDRplus) and treatment outcomes and mortality in MDR-TB patients in Peru. " 05/20/2009 - "The four direct tests included two in-house phenotypic assays - Nitrate Reductase Assay (NRA) and Microscopic Observation Drug Susceptibility (MODS), and two commercially available tests - Genotype MTBDR and Genotype MTBDRplus (Hain Life Sciences, Nehren, Germany). " 09/01/2013 - "This study was undertaken in an effort to evaluate the accuracy of two rapid culture methods: the Microscopic Observation Drug Susceptibility assay (MODS) and Nitrate Reductase Assay (NRA), and the molecular based test Xpert® MTB/Rif (Xpert), for diagnosis of smear-negative TB in HIV patients using the mycobacteria growth indicator tube (MGIT) in the BACTEC(TM) MGIT(TM) 960 system as the reference test. "
2.	Dehydration (Water Stress) 05/01/2021 - "The data procured from current investigation indicated that water stress significantly declined the plant growth, leaf area in addition to photosynthetic efficiency, nitrate reductase activity and crop yield at various stages of growth such as vegetative (VS), flowering (FS) and pod filling stage (PFS). " 04/01/2015 - "Water stress significantly decreased the nitrate reductase activity. " 01/01/2009 - "The data herein demonstrate that, while nitrate reductase (NR)1-mediated NO generation is required for the ABA-induced closure of stomata in turgid leaves, it is not required for ABA-enhanced stomatal closure under conditions leading to rapid dehydration. " 02/01/2008 - "Water stress-induced defense increases in the production of NO were blocked by pretreatments with inhibitors of NOS and nitrate reductase (NR), suggesting that NO is produced from NOS and NR in leaves of maize plants exposed to water stress. " 06/01/1991 - "Assimilatory nitrate reductase activity (NRA) in crude spinach leaf (Spinacia oleracea) extracts undergoes rapid changes following fluctuations in photosynthesis brought about by changes in external CO(2) or by water stress (WM Kaiser, E Brendle-Behnisch [1991] Plant Physiol 96:363-367). "
3.	Tuberculosis (Tuberculoses) 02/01/2014 - "To perform a multicentre study evaluating the performance of the direct nitrate reductase assay (NRA) for the detection of multidrug-resistant (MDR) and extensively drug-resistant (XDR) tuberculosis in sputum samples. " 01/01/2018 - "Evaluation of Nitrate Reductase Assay for Early Detection of Multi and Extensively Drug Resistance Tuberculosis in our Setup." 04/01/2015 - "Evaluation of direct microplate nitrate reductase assay as a rapid method for the detection of multiple and extensively tuberculosis drug resistance." 02/01/2015 - "tuberculosis was confirmed by demonstrating the loss of assimilatory and respiratory nitrate reductase activity in a mobA deletion mutant. " 09/01/2013 - "Evaluation of the Xpert® MTB/Rif test, microscopic observation drug susceptibility test and nitrate reductase assay, for rapid and accurate diagnosis of smear-negative tuberculosis in HIV patients."
4.	Hypoxia (Hypoxemia) 01/01/2019 - "Hypoxia-induced synthesis of respiratory nitrate reductase 2 of Streptomyces coelicolor A3(2) depends on the histidine kinase OsdK in mycelium but not in spores." 12/01/2017 - "Here, we investigated whether ethylene-induced aerenchyma requires hypoxia-induced NO. Under hypoxic conditions, wheat roots produced NO apparently via nitrate reductase and scavenging of NO led to a marked reduction in aerenchyma formation. " 01/01/2017 - "In addition, atvR was more expressed in hypoxia in the presence of nitrate and required for full expression of nitrate reductase genes, promoting bacterial growth under this condition. " 12/15/2016 - "We also tested whether liver, muscle and heart tissue possess nitrate reductase activity that supplies nitrite to the tissues during severe hypoxia. " 12/01/2004 - "The mechanism of nitrate reductase (NR) regulation under long-term anoxia in roots of whole plants and the putative role of nitrate in anoxia tolerance have been addressed. "
5.	Multiple Sclerosis 09/01/2001 - "Cerebrospinal fluid and serum nitric oxide levels were measured blind as nitrite plus nitrate, using the nitrate reductase and Griess reaction method in 20 patients with multiple sclerosis before and after corticosteroid therapy, and during remission period, and in 20 control subjects. "

Related Drugs and Biologics

1.	Proteins (Proteins, Gene)
2.	resazurin
3.	Indicators and Reagents (Reagents)
4.	Agar
5.	Fluoroquinolones
6.	Salicylic Acid (2 Hydroxybenzoic Acid)
7.	Moxifloxacin (Avelox)
8.	Nitrates
9.	Nitrogen
10.	Nitrites

Related Therapies and Procedures

1.	Therapeutics
2.	Surgical Instruments (Clip)
3.	Critical Care (Surgical Intensive Care)
4.	Canes (Cane)
5.	CHOP-B protocol