HSP72 Heat-Shock Proteins

Stress-inducible members of the heat-shock proteins 70 family. HSP72 heat shock proteins function with other MOLECULAR CHAPERONES to mediate PROTEIN FOLDING and to stabilize pre-existent proteins against aggregation.

Also Known As:

HSP-72 Protein; HSP70-1 Heat Shock Proteins; Heat Shock Protein 72; Heat-Shock Protein p72; Hsp72 Protein; HSP 72 Protein; HSP70 1 Heat Shock Proteins; HSP72 Heat Shock Proteins; Heat Shock Protein p72; Heat-Shock Proteins, HSP72; p72, Heat-Shock Protein; Heat Shock Proteins 72

Networked: 267 relevant articles (11 outcomes, 26 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Molecular Chaperones: 1279
    - Heat-Shock Proteins: 8088
      - HSP70 Heat-Shock Proteins: 1903
        HSP72 Heat-Shock Proteins: 267

Experts

1.	Takahashi, Naohiko: 10 articles (12/2011 - 07/2003)
2.	Saikawa, Tetsunori: 9 articles (12/2011 - 07/2003)
3.	Ooie, Tatsuhiko: 8 articles (12/2011 - 07/2003)
4.	Yoshimatsu, Hironobu: 8 articles (12/2011 - 07/2003)
5.	Lin, Mao-Tsun: 7 articles (09/2016 - 02/2005)
6.	Shinohara, Tetsuji: 7 articles (12/2011 - 11/2004)
7.	Powers, Scott K: 6 articles (11/2015 - 04/2003)
8.	Wang, Xiaoping: 6 articles (02/2013 - 04/2007)
9.	Hara, Masahide: 6 articles (12/2011 - 11/2004)
10.	Henstridge, Darren C: 5 articles (01/2018 - 02/2008)

Related Diseases

1.	Reperfusion Injury 09/24/2002 - "Heat shock protein 72 (HSP72) is known to provide myocardial protection against ischemia-reperfusion injury by its chaperoning function. " 08/01/1995 - "This study evaluated whether induction of heat-shock protein 72 protects against intestinal ischemia/reperfusion injury. " 10/01/2006 - "Sex differences in heat shock protein 72 expression and localization in rats following renal ischemia-reperfusion injury." 07/01/2000 - "Heat shock protein 72 (HSP72) is involved in the myocardial self-preservation system under several conditions such as ischemia-reperfusion injury or late preconditioning. " 03/01/1999 - "Induction of heat-shock protein 72 in rat skeletal muscle does not increase tolerance to ischemia-reperfusion injury."
2.	Myocardial Ischemia (Ischemic Heart Diseases) 04/01/2003 - "Endurance exercise is associated with protection against myocardial ischemia/reperfusion (I/R) injury and has been shown to increase heat shock protein 72 (HSP72). " 07/01/1997 - "We compared the time course of tolerance to myocardial ischemia-reperfusion injury with the time course of heat shock protein 72 (hsp72; inducible form) induction after heat stress in a rat model. " 09/24/2002 - "Heat shock protein 72 enhances manganese superoxide dismutase activity during myocardial ischemia-reperfusion injury, associated with mitochondrial protection and apoptosis reduction." 11/01/1998 - "The transgenic mice overexpressing heat shock protein 72 (HSP72) or antioxidants have been reported to be more resistant to myocardial ischemia/reperfusion injury. " 06/20/2008 - "Nitric oxide induces heat shock protein 72 production and delayed protection against myocardial ischemia in rabbits via activating protein kinase C."
3.	Ischemia 01/01/2006 - "The purpose of this study was to investigate (1) whether ischemia-reperfusion increased the content of heat shock protein 72 (Hsp72) transcripts and (2) whether myocardial content of Hsp72 is increased by ischemic preconditioning so that they can be considered as end effectors of preconditioning. " 01/01/2006 - "Our experimental model is valid and the experimental techniques are appropriate, but the induction of heat shock proteins 72 as end effectors of cardioprotection in ischemic preconditioning does not occur in the first hours after ischemia, but probably at least 24 hours after it, in the so-called "second protection window."" 01/01/2004 - "After 6 min of ischemia, a more robust and wide spread HSP72 protein expression in both dorsal and ventral horn neurons was detected. " 01/01/2004 - "After 3 min of ischemia, there was a modest increase in HSP72 protein immunoreactivity in the dorsal horn neurons at 12 h after reperfusion. " 07/01/2003 - "We have previously demonstrated that clinically applicable thermal preconditioning induces heat shock protein 72 (HSP72) and protects against a subsequent ischemia-reperfusion (I/R) injury in an animal model. "
4.	Insulin Resistance 08/01/2021 - "The aims of this study were to investigate the effects of ST on mitochondrial adaptation in skeletal muscle and adipose tissue, on heat shock protein 72 (Hsp72) in skeletal muscle, and on visceral adipocyte size in mice with high-fat diet (HFD)-induced insulin resistance. " 07/01/2022 - "Herein, we tested the hypothesis that endothelial insulin resistance in T2D is attributed to reduced expression of heat shock protein 72 (HSP72). " 01/01/2020 - "An involvement of heat shock protein 72 (HSP72) in the enhancement of insulin sensitivity upon heat exposure has been previously suggested. " 05/01/2014 - "Elevated levels of extracellular heat-shock protein 72 (eHSP72) are positively correlated with insulin resistance in vivo and cause pancreatic β-cell dysfunction and death in vitro." 11/01/2010 - "A lower expression of HSP72 protein in human skeletal muscle was associated with increased adiposity and decreased insulin sensitivity in healthy individuals. "
5.	Ulcer 09/01/2007 - "It has been shown that orally administered geranylgeranylacetone (GGA), an anti-ulcer drug, induces expression of heat shock protein 72 (HSP72) and provides protection against ischemia-reperfusion in rat hearts. " 11/10/2006 - "In this study, we investigated the effects of zinc L-carnosine, an anti-ulcer drug, on acetic acid-induced colonic mucosal injury and the correlation of these effects with expression of 72-kDa heat shock proteins (HSP72) and nuclear factor kappa B (NF-kappaB) activation in rat colonic mucosa in vivo. "

Related Drugs and Biologics

1.	geranylgeranylacetone (teprenone)
2.	Nitric Oxide (Nitrogen Monoxide)
3.	Lipopolysaccharides
4.	Protein Kinase C
5.	Glutathione (Reduced Glutathione)
6.	Proteins (Proteins, Gene)
7.	Heat-Shock Proteins (Heat-Shock Protein)
8.	NF-kappa B (NF-kB)
9.	Glutamine (L-Glutamine)
10.	Glucose (Dextrose)

Related Therapies and Procedures

1.	Cardiopulmonary Bypass (Heart-Lung Bypass)
2.	Therapeutics
3.	Induced Hyperthermia (Thermotherapy)
4.	Induction Chemotherapy
5.	Excimer Lasers