HSC70 Heat-Shock Proteins

A constitutively expressed subfamily of the HSP70 heat-shock proteins. They preferentially bind and release hydrophobic peptides by an ATP-dependent process and are involved in post-translational PROTEIN TRANSLOCATION.

Also Known As:

70 kDa Heat-Shock Cognate Protein; Clathrin Uncoating Protein; HSC73 Protein; 70 kDa Heat Shock Cognate Protein; HSC70 Heat Shock Proteins; Heat Shock Cognate 70 Protein; Heat-Shock Proteins, HSC70; Uncoating Protein, Clathrin; Heat-Shock Cognate 70 Protein; Hsc70 Protein

Networked: 19 relevant articles (0 outcomes, 3 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Molecular Chaperones: 1279
    - Heat-Shock Proteins: 8088
      - HSP70 Heat-Shock Proteins: 1903
        HSC70 Heat-Shock Proteins: 19
        Drosophila Hsc70-3 protein
        Drosophila Hsc70-4 protein
        human HSPA8 protein
        Lycopersicon esculentum hsc70-3 protein
        mouse Hspa8 protein
        rat Hspa8 protein
        Xenopus Heat shock cognate protein 70
        zebrafish hspa8 protein

Experts

1.	Caprioli, Joseph: 2 articles (05/2003 - 01/2003)
2.	Ishii, Yoko: 2 articles (05/2003 - 01/2003)
3.	Kwong, Jacky M K: 2 articles (05/2003 - 01/2003)
4.	Acosta, Orlando: 1 article (08/2021)
5.	Guerrero, Carlos: 1 article (08/2021)
6.	Hernandez, Juan: 1 article (08/2021)
7.	Perez, Claudia: 1 article (08/2021)
8.	Rico, José: 1 article (08/2021)
9.	Storey, Janet M: 1 article (01/2019)
10.	Storey, Kenneth B: 1 article (01/2019)

Related Diseases

1.	Glaucoma 05/01/2003 - "To study the effects of geranylgeranylacetone (GGA) on the expression of inducible (HSP72) and constitutive (HSC70) heat shock proteins (HSPs) on retinal ganglion cells (RGCs) in a rat model of glaucoma. " 01/01/2003 - "To study the effects of geranylgeranylacetone (GCA) on the expression of inducible (HSP72) and constitutive (HSC70) heat shock proteins (HSPs) on retinal ganglion cells (RGCs) in a rat model of glaucoma. "
2.	Hypoxia (Hypoxemia) 07/01/2006 - "[HSC70 protein of human blood mononuclears as a sign of adaptation under normobaric hypoxia training]." 10/31/2003 - "Hsc70 message and subcellular distribution of Hsc70 protein were unaffected by chronic hypoxia. " 01/01/2019 - "The present study analyzes responses to freezing, anoxia or dehydration exposures and recovery from these stresses by chaperone proteins in six wood frog organs: Five heat shock proteins (Hsc70, Hsp110, Hsp60, Hsp40, and Hsp10) and two glucose-regulated proteins (Grp78 and Grp94) were assessed. "
3.	Dehydration (Water Stress) 01/01/2019 - "The present study analyzes responses to freezing, anoxia or dehydration exposures and recovery from these stresses by chaperone proteins in six wood frog organs: Five heat shock proteins (Hsc70, Hsp110, Hsp60, Hsp40, and Hsp10) and two glucose-regulated proteins (Grp78 and Grp94) were assessed. "
4.	Neoplasms (Cancer) 01/07/2010 - "Heat shock cognate 70 protein secretion as a new growth arrest signal for cancer cells." 03/01/2004 - "Tumors with weak (+) HSC70 protein staining were more frequent in the carriers of the polymorphic 1541-1542delGT allele than in the homozygotes of the major allele (20% vs. 6%, P=0.05 by Fisher's exact test). " 11/15/1993 - "70 kDa heat shock cognate protein is a transformation-associated antigen and a possible target for the host's anti-tumor immunity." 08/01/2021 - "The results indicated that the rotavirus isolates studied were able to infect U937 cells by interacting with Hsp90, Hsp70, Hsp60, Hsp40, Hsc70, protein disulfide isomerase (PDI), and integrin β3, which are implicated in cellular proliferation, differentiation, and cancer development. "
5.	Parkinson Disease (Parkinson's Disease) 02/10/2014 - "Reduced expression of the chaperone-mediated autophagy carrier hsc70 protein in lymphomonocytes of patients with Parkinson's disease." 01/01/2012 - "We recently described the effect of the constitutively expressed chaperone, Hsc70 protein, on α‑Synuclein aggregation, a phenomenon associated with Parkinson disease. " 01/01/2012 - "The interaction of Hsc70 protein with fibrillar α-Synuclein and its therapeutic potential in Parkinson's disease."

Related Drugs and Biologics

1.	geranylgeranylacetone (teprenone)
2.	Proteins (Proteins, Gene)
3.	Endoplasmic Reticulum Chaperone BiP
4.	glucose-regulated proteins
5.	Synucleins
6.	Protein Disulfide-Isomerases
7.	Integrins
8.	RNA (Ribonucleic Acid)
9.	Camphor
10.	Antigens

Related Therapies and Procedures

1.	Injections