CREB-Binding Protein

A member of the p300-CBP transcription factor family that was initially identified as a binding partner for CAMP RESPONSE ELEMENT-BINDING PROTEIN. Mutations in CREB-binding protein are associated with RUBINSTEIN-TAYBI SYNDROME.

Also Known As:

Networked: 159 relevant articles (2 outcomes, 9 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Barco, Angel: 4 articles (01/2014 - 06/2004)
2.	Wright, Peter E: 3 articles (12/2014 - 01/2004)
3.	Latchman, David S: 3 articles (02/2007 - 02/2003)
4.	Chen, Rui: 2 articles (01/2015 - 09/2014)
5.	Xu, Min: 2 articles (01/2015 - 09/2014)
6.	Gerard, Robert D: 2 articles (01/2015 - 09/2014)
7.	Garcia, Joseph A: 2 articles (01/2015 - 09/2014)
8.	Nagati, Jason S: 2 articles (01/2015 - 09/2014)
9.	Brindle, Paul K: 2 articles (12/2014 - 11/2005)
10.	Kahn, Michael: 2 articles (11/2013 - 08/2010)

Related Diseases

1.	Anoxia (Hypoxia) 05/17/2013 - "Homeostatic response to hypoxia is primarily mediated by hypoxia inducible factor (HIF)-1α that elicits transcriptional activity through recruitment of the CREB binding protein (CBP)/p300 coactivator. " 01/22/2010 - "Complex regulation of the transactivation function of hypoxia-inducible factor-1 alpha by direct interaction with two distinct domains of the CREB-binding protein/p300." 01/01/2000 - "The hypoxia-inducible activity of both these domains was enhanced by either SRC-1 or the CREB-binding protein (CBP)/p300 coactivator. " 01/01/2000 - "Redox-regulated recruitment of the transcriptional coactivators CREB-binding protein and SRC-1 to hypoxia-inducible factor 1alpha." 11/16/1998 - "Here we demonstrate that the mechanism of activation of HIF-1alpha is a multi-step process which includes hypoxia-dependent nuclear import and activation (derepression) of the transactivation domain, resulting in recruitment of the CREB-binding protein (CBP)/p300 coactivator. "
2.	Neoplasms (Cancer) 01/07/2011 - "Our previous study indicated that the transcriptional activity of RA receptor (RAR) is enhanced by association of MED25 with CREB-binding protein (CBP) through the PTOV domain, which is also present in prostate tumor over-expressed protein 1 (PTOV1). " 04/01/2010 - "CREB-binding protein (CBP) is involved in the apoptotic pathway in several tumor cells, however, little is known whether CBP is associated with apoptosis in ECs and the apoptotic effect of CBP on ECs is regulated by NO. Therefore, the purpose of the present study was to investigate whether silencing CBP expression could affect the sensitivity of ECs toward apoptotic stimuli and determined the role of NO. In this study, we found that when CBP expression was silenced by RNA interference, ECs were more prone to apoptosis under serum deprivation, whereas the apoptosis was not significantly induced in the serum-containing condition. " 04/01/2012 - "Mice heterozygous for CREB binding protein are hypersensitive to γ-radiation and invariably develop myelodysplastic/myeloproliferative neoplasm." 05/07/2004 - "We recently reported that MDM2, a negative feedback regulator of the tumor suppressor p53, inhibits p300/CREB-binding protein-associated factor (PCAF)-mediated p53 acetylation. " 09/01/2002 - "The tumor suppressors p300 and CREB-binding protein (CBP) are both multifunctional transcriptional coactivators. "
3.	Infection 04/01/2005 - "In this study, we demonstrate that IRF3 and IRF7, which with the coactivators CREB-binding protein and P300 form the virus-activated factor (VAF) complex upon Sendai virus infection, bind to the IRF7 ISRE and IRFE and can directly activate IRF7 transcription. " 02/01/2005 - "Other signs of IRF-3 activation such as hyperphosphorylation, homodimer formation, and recruitment of the coactivator CREB-binding protein (CBP) were found late after infection with the control virus but not with SARS-CoV. " 09/01/2013 - "Rather, VP16 interacted with the CREB binding protein (CBP) coactivator and efficiently inhibited the formation of the transcriptional complexes IRF-3-CBP in the context of HSV-1 infection. " 06/20/2013 - "E1A can induce marked epigenetic reprogramming of the cell within hours after infection, through interactions with a diverse set of partners that include key host regulators such as the general transcriptional coactivator CREB binding protein (CBP), its paralogue p300, and the retinoblastoma protein (pRb; also called RB1). " 07/15/2008 - "After Legionella infection, HATs p300 and CREB-binding protein were time-dependently recruited to the IL-8 promoter, whereas HDAC1 and HDAC5 first decreased and later reappeared at the promoter. "
4.	Breast Neoplasms (Breast Cancer) 12/05/2000 - "One of the p160 factors, p/CIP/AIB1, often amplified and overexpressed in breast cancer, also exhibits particularly strong interaction with CREB-binding protein/p300. " 02/01/1998 - "Earlier experiments have demonstrated that the breast cancer-associated tumor suppressor BRCA1 and the CREB binding protein (CBP) were associated with the holoenzyme complex. " 03/30/2007 - "PTHrP P3 promoter activity in breast cancer cell lines: role of Ets1 and CBP (CREB binding protein)." 07/01/1998 - "It belongs to a growing coactivator family that includes a steroid receptor coactivator amplified in breast cancer (AIB1), p300/ CREB-binding protein (CBP)-interacting protein (p/ CIP), and transcriptional intermediate factor 2 (TIF2). " 03/01/2000 - "Here we provide evidence that the hormone-occupied PR forms a multisubunit receptor-coactivator complex containing two previously described coactivators, CREB-binding protein (CBP) and steroid receptor coactivator 1 (SRC-1, a member of the p160 family of coactivators), in nuclear extracts of human breast tumor T47D cells. "
5.	Alzheimer Disease (Alzheimer's Disease) 01/01/2015 - "Drosophila Eye Model to Study Neuroprotective Role of CREB Binding Protein (CBP) in Alzheimer's Disease." 02/14/2007 - "We have shown that wild type (WT) Presenilin 1 (PS1) stimulates the transcriptional activity ability of CREB Binding Protein (CBP), a close homolog of p300, whereas the Alzheimer's disease (AD) associated mutant of PS1 does not have this effect. " 06/26/2006 - "Recently, a report has suggested a link between CREB-binding protein and presenilins, which are mutated in many cases of early onset Alzheimer's disease. "

Related Drugs and Biologics

1.	Cyclic AMP Response Element-Binding Protein (Cyclic AMP-Responsive DNA-Binding Protein)
2.	Glucose (Dextrose)
3.	Small Interfering RNA (siRNA)
4.	Estrogens (Estrogen)
5.	A-factor (Streptomyces)
6.	Carbon Monoxide
7.	Histones (Histone)
8.	Steroid Receptors (Steroid Receptor)
9.	Nuclear Receptor Coactivator 2
10.	Interleukin-6 (Interleukin 6)

Related Therapies and Procedures

1.	Moxibustion
2.	Ligation