Interferon Regulatory Factor-7 (Interferon Regulatory Factor 7)

An interferon regulatory factor that is induced by INTERFERONS as well as LMP-1 protein from EPSTEIN-BARR VIRUS. IRF-7 undergoes PHOSPHORYLATION prior to nuclear translocation and it activates GENETIC TRANSCRIPTION of multiple interferon GENES.

Also Known As:

Interferon Regulatory Factor 7; IRF-7A Transcription Factor; IRF-7B Transcription Factor; IRF-7C Transcription Factor; Factor, IRF-7C Transcription; IRF 7 Transcription Factor; IRF 7A Transcription Factor; IRF 7B Transcription Factor; IRF 7C Transcription Factor; Transcription Factor, IRF-7A; Transcription Factor, IRF-7B; Transcription Factor, IRF-7C; IRF-7 Transcription Factor

Networked: 107 relevant articles (3 outcomes, 10 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
- Peptides: 82426
  - Intracellular Signaling Peptides and Proteins: 32
    - Signal Transducing Adaptor Proteins
      - Interferon Regulatory Factors: 701
        Interferon Regulatory Factor-7: 107
        human IRF7 protein
        mouse Irf7 protein

Experts

1.	Pagano, Joseph S: 4 articles (09/2017 - 09/2003)
2.	Wu, Ying: 3 articles (01/2021 - 01/2019)
3.	Wang, Tao: 3 articles (01/2020 - 08/2013)
4.	Li, Hongliang: 3 articles (10/2014 - 08/2013)
5.	Zhang, Xiao-Dong: 3 articles (10/2014 - 08/2013)
6.	Ambite, Ines: 2 articles (01/2022 - 01/2016)
7.	Butler, Daniel: 2 articles (01/2022 - 01/2016)
8.	Li, Jing: 2 articles (01/2022 - 01/2019)
9.	Svanborg, Catharina: 2 articles (01/2022 - 01/2016)
10.	Zhou, Xiaodong: 2 articles (01/2022 - 11/2019)

Related Diseases

1.	Infections 05/10/2013 - "Interferon regulatory factor 7 (IRF7) is required for the optimal initial control but not subsequent clearance of lymphocytic choriomeningitis virus infection in mice." 01/01/2007 - "The susceptibility of HPV18/E6E7-immortalized hepatocytes to HCV infection was further improved, in particular, by impairing signaling through interferon regulatory factor-7. " 01/01/2022 - "pylori infection-mediated phosphorylation of interferon regulatory factor 7 (IRF7). " 01/01/2021 - "Interferon regulatory factor 7 (IRF7) has been identified as a significant regulator in corneal endothelial cells after an HSV-1 infection. " 01/01/2021 - "Role of interferon regulatory factor 7 in corneal endothelial cells after HSV-1 infection."
2.	Hypersensitivity (Allergy) 09/01/2007 - "Recent results have shown that Talpha1: (a) primed DCs for antifungal Th1 resistance through Toll-like receptor (TLR)/MyD88-dependent signaling and this translated in vivo in protection against aspergillosis; (b) activated plasmacytoid DCs (pDC) via the TLR9/MyD88-dependent viral recognition, thus leading to the activation of interferon regulatory factor 7 and the promotion of the IFN-alpha/IFN-gamma-dependent effector pathway, which resulted in vivo in protection against primary murine cytomegalovirus infection; (c) induced indoleamine 2,3-dioxygenase activity in DCs, thus affecting tolerization toward self as well as microbial non-self-antigens, and this resulted in vivo in transplantation tolerance and protection from inflammatory allergy. "
3.	Aspergillosis 09/01/2007 - "Recent results have shown that Talpha1: (a) primed DCs for antifungal Th1 resistance through Toll-like receptor (TLR)/MyD88-dependent signaling and this translated in vivo in protection against aspergillosis; (b) activated plasmacytoid DCs (pDC) via the TLR9/MyD88-dependent viral recognition, thus leading to the activation of interferon regulatory factor 7 and the promotion of the IFN-alpha/IFN-gamma-dependent effector pathway, which resulted in vivo in protection against primary murine cytomegalovirus infection; (c) induced indoleamine 2,3-dioxygenase activity in DCs, thus affecting tolerization toward self as well as microbial non-self-antigens, and this resulted in vivo in transplantation tolerance and protection from inflammatory allergy. "
4.	Virus Diseases (Viral Diseases) 03/31/2006 - "Interferon regulatory factor 7 (IRF7) is a key component of the cellular response to virus infection that culminates in physiologically relevant IFNalpha production. " 11/21/2003 - "Firstly, it is transcribed constitutively, independent of viral infection and of interferon regulatory factor-7 induction. " 06/17/2016 - "In this study, we found that viral infection-induced up-regulation of Usp25 is diminished in cells lacking interferon regulatory factor 7 (IRF7) or interferon α receptor 1 (IFNAR1) but not p65. " 01/01/2021 - "Chicken interferon regulatory factor 7 (IRF7) can control ALV-J virus infection by triggering type I interferon production through affecting genes related with innate immune signaling pathway." 01/01/2019 - "Interferon regulatory factor 7 (IRF7), a crucial regulator of type I interferons (IFNs), plays a crucial role in resistance to viral infection. "
5.	Systemic Lupus Erythematosus (Libman-Sacks Disease) 09/01/2011 - "The potential role of interferon-regulatory factor 7 among Taiwanese patients with systemic lupus erythematosus." 08/01/2011 - "Hematopoietic stem cell transplant for systemic lupus erythematosus: Interferon regulatory factor 7 activation correlates with the IFN signature and recurrent disease." 03/01/2011 - "A previous genome-wide association study conducted in a population of European ancestry identified rs4963128, a KIAA1542 single-nucleotide polymorphism (SNP) 23 kb telomeric to IRF7 (the gene for interferon regulatory factor 7 [IRF-7]), to be strongly associated with systemic lupus erythematosus (SLE). " 11/06/2014 - "This study aimed to explore the role of apoptosis initiators, caspase-9, caspase-10, mitochondrial anti-viral signaling protein (MAVS), and interferon regulatory factor 7 (pIRF7), in patients with systemic lupus erythematosus (SLE). " 11/01/2020 - "Food and Drug Administration; FOS: Fos Proto-Oncogene, AP-1 Transcription Factor Subunit; HLA: Human Leukocyte Antigen; HLA-DRA: Major Histocompatibility Complex, Class II, DR Alpha; ICAM1: Intercellular Adhesion Molecule 1; IFNG: Interferon Gamma; IGF-1: Insulin-like Growth Factor 1; IGF-1R: Insulin-like Growth Factor-1 Receptor; IL12B: Interleukin 12B; IL23R: Interleukin 23 Receptor; IL6: Interleukin 6; IOP: Intraocular Pressure; IRF1: Interferon Regulatory Factor 1; IRF5: Interferon Regulatory Factor 5; IRF7: Interferon Regulatory Factor 7; IRF9: Interferon Regulatory Factor 9; JUN: Jun Proto-Oncogene, AP-1 Transcription Factor Subunit; JUNB: JunB Proto-Oncogene, AP-1 Transcription Factor Subunit; MHC: Major Histocompatibility Complex; MRI: Magnetic Resonance Imaging; NFKB1: Nuclear Factor Kappa B Subunit 1; NFKBIA: Nuclear Factor Kappa B Inhibitor Alpha; OADSCs: Orbital Adipose Derived Stromal Cells; PDGFB: Platelet Derived Growth Factor Subunit B; PPARG: Peroxisome Proliferator Activated Receptor Gamma; RANTES: Regulated on Activation Normal T cell Expressed and Secreted; RARA: Retinoic Acid Receptor Alpha; RCTs (Randomized Controlled Trials; SLE: Systemic lupus erythematosus; SOCS3: Suppressor of Cytokine Signaling 3; STAT1: Signal Transducer and Activator of Transcription 1; TAO: Thyroid-Associated Ophthalmopathy; TED: Thyroid eye disease; TGFB1: Transforming Growth Factor Beta 1; TGFB2: Transforming Growth Factor Beta 2; TGF-β: Transforming Growth Factor-beta; TLR7: Toll like Receptor 7; TLR9: Toll like Receptor 9; TNFRSF18: Tumor Necrosis Factor Receptor Superfamily Member 18; TNFSF11: Tumor Necrosis Factor Receptor Superfamily Member 11; TNF-α: Tumor Necrosis Factor-alpha; TSHR: Thyroid Stimulating Hormone Receptor; TSIs: Thyroid Stimulating Immunoglobulin; WNT5A: Wingless-Type MMTV Integration Site Family, Member 5A."

Related Drugs and Biologics

1.	Toll-Like Receptors (Toll-Like Receptor)
2.	Indoleamine-Pyrrole 2,3,-Dioxygenase (Indoleamine 2,3 Dioxygenase)
3.	Autoantigens
4.	Transcription Factors (Transcription Factor)
5.	Interferons
6.	Interferon Type I
7.	Proteins (Proteins, Gene)
8.	Cytokines
9.	Interleukin-6 (Interleukin 6)
10.	Toll-Like Receptor 9

Related Therapies and Procedures

1.	Transplantation
2.	Therapeutics
3.	Spinal Injections