L-Amino Acid Oxidase

An enzyme that catalyzes the oxidative deamination of L-amino acids to KETO ACIDS with the generation of AMMONIA and HYDROGEN PEROXIDE. L-amino acid oxidase is widely distributed in and is thought to contribute to the toxicity of SNAKE VENOMS.

Also Known As:

Networked: 45 relevant articles (2 outcomes, 9 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Chávez-Olórtegui, Carlos: 3 articles (07/2019 - 10/2015)
2.	Othman, Iekhsan: 3 articles (11/2018 - 01/2017)
3.	Vivas-Ruiz, Dan E: 2 articles (07/2019 - 01/2019)
4.	Yarlequé, Armando: 2 articles (07/2019 - 01/2019)
5.	Guerra-Duarte, Clara: 2 articles (01/2019 - 10/2015)
6.	Stransky, Stephanie: 2 articles (01/2019 - 10/2015)
7.	Naidu, Rakesh: 2 articles (11/2018 - 01/2018)
8.	Rajadurai, Pathmanathan: 2 articles (11/2018 - 01/2018)
9.	Zainal Abidin, Syafiq Asnawi: 2 articles (11/2018 - 01/2018)
10.	Mackessy, Stephen P: 2 articles (07/2018 - 10/2015)

Related Diseases

1.	Glioma (Gliomas) 01/01/1997 - "These studies evaluated the efficacy of sequential pretreatment with L-amino acid oxidase (LOX) and LOX antiserum in the modulation of melphalan activity against intracranial glioma in athymic nude mice. " 01/01/1997 - "L-amino acid oxidase (LOX) modulation of melphalan activity against intracranial glioma."
2.	Snake Bites (Snake Bite) 01/09/2013 - "Strong inhibition of l-amino acid oxidase may give partial relief from snake bite after topical application of the extract." 09/01/2021 - "One of the deadliest enzymes in the snake venom is l-amino acid oxidase (LAAO) which plays an important role in the pathophysiological effects during snake envenomation. "
3.	Infections 07/01/2023 - "The current study showed that both human trophoblast cells (BeWo lineage) and human explant villous were resistant to T. gondii infection after incubation with BjussuLAAO-II, an l-amino acid oxidase isolated from Bothrops jararacussu. " 10/01/2017 - "In our previous studies, we found that rabbitfish (Siganus oramin) displayed high resistance to C. irritans infection, and a novel protein, l-amino acid oxidase (LAAO), was identified from the serum that was lethal to C. irritans. " 01/01/2021 - "Expression profile of the fish immune enzyme l-amino acid oxidase (LAAO) after Streptococcus agalactiae infection in zebrafish (Danio rerio)."
4.	Colonic Neoplasms (Colon Cancer) 11/01/2018 - "Cytotoxic, Antiproliferative and Apoptosis-inducing Activity of L-Amino Acid Oxidase from Malaysian Calloselasma rhodostoma on Human Colon Cancer Cells." 11/01/2018 - "The aim of this study was to investigate the cytotoxic, antiproliferative activity and the induction of apoptosis by L-amino acid oxidase isolated from Calloselasma rhodostoma crude venom (CR-LAAO) on human colon cancer cells. " 11/05/2021 - "L-amino acid oxidase from snake venom: Biotransformation and induction of apoptosis in human colon cancer cells." 01/01/2018 - "Cytotoxic, Anti-Proliferative and Apoptosis Activity of l-Amino Acid Oxidase from Malaysian Cryptelytrops purpureomaculatus (CP-LAAO) Venom on Human Colon Cancer Cells." 01/01/2018 - "The aim of this study is to investigate the potential anti-cancer activity of l-amino acid oxidase (CP-LAAO) purified from the venom of Cryptelytrops purpureomaculatus on SW480 and SW620 human colon cancer cells. "
5.	Neoplasms (Cancer) 11/05/2021 - "Induction of apoptosis by L-amino acid oxidase was in correlation with oxidative disbalance in cancer cells. " 01/01/2023 - "Our results demonstrated that Pollonein-LAAO, a new L-amino acid oxidase obtained from Bothrops moojeni venom, was cytotoxic to PC-3 cells in two-dimensional and in tumor spheroid assays. " 01/01/2023 - "Oxidative stress induced by Pollonein-LAAO, a new L-amino acid oxidase from Bothrops moojeni venom, prompts prostate tumor spheroid cell death and impairs the cellular invasion process in vitro." 01/01/2017 - "CR-LAAO, an L-amino acid oxidase from Calloselasma rhodostoma venom, as a potential tool for developing novel immunotherapeutic strategies against cancer." 09/01/2016 - "Isolation, characterization and screening of the in vitro cytotoxic activity of a novel L-amino acid oxidase (LAAOcdt) from Crotalus durissus terrificus venom on human cancer cell lines."

Related Drugs and Biologics

1.	Melphalan (Alkeran)
2.	Snake Venoms (Snake Venom)
3.	Venoms
4.	MicroRNAs (MicroRNA)
5.	Viper Venoms (Viper Venom)
6.	Superoxides (Superoxide)
7.	Proteins (Proteins, Gene)
8.	Glutathione (Reduced Glutathione)
9.	Ethidium (Ethidium Bromide)
10.	Acridine Orange

Related Therapies and Procedures

1.	Therapeutics