Synaptosomal-Associated Protein 25

A ubiquitous target SNARE protein that interacts with SYNTAXIN and SYNAPTOBREVIN. It is a core component of the machinery for intracellular MEMBRANE FUSION. The sequence contains 2 SNARE domains, one is the prototype for the Qb-SNARES, and the other is the prototype for the Qc-SNARES.

Also Known As:

Networked: 72 relevant articles (0 outcomes, 12 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Fagan, Anne M: 3 articles (01/2021 - 01/2020)
2.	Henson, Rachel L: 3 articles (01/2021 - 01/2020)
3.	Ances, Beau M: 2 articles (01/2021 - 01/2021)
4.	Christian, Bradley T: 2 articles (01/2021 - 01/2020)
5.	Doran, Eric: 2 articles (01/2021 - 01/2020)
6.	Handen, Benjamin L: 2 articles (01/2021 - 01/2020)
7.	Klunk, William E: 2 articles (01/2021 - 01/2020)
8.	Lai, Florence: 2 articles (01/2021 - 01/2020)
9.	Lee, Joseph H: 2 articles (01/2021 - 01/2020)
10.	Lott, Ira T: 2 articles (01/2021 - 01/2020)

Related Diseases

1.	Attention Deficit Disorder with Hyperactivity (Attention Deficit Hyperactivity Disorder) 01/01/2023 - "Although synaptosomal-associated protein 25 (SNAP-25) is a possible gene hypothesized to be associated with working memory deficits in ADHD, little is known about its specific impact on the hippocampus. " 10/01/2022 - "The MnlI variant (rs3746544) of the synaptosomal-associated protein 25 (SNAP-25) gene is associated with ADHD. " 07/01/2013 - "SNAP-25 protein expression is lower in different brain areas of schizophrenic patients and in ADHD mouse models. " 01/01/2006 - "Many authors describe the connection between ADHD development and the synaptosomal-associated protein 25 (SNAP-25) gene. " 01/01/2002 - "Synaptosomal-associated protein 25 (SNAP-25) and attention deficit hyperactivity disorder (ADHD): evidence of linkage and association in the Irish population."
2.	Schizophrenia (Dementia Praecox) 05/01/2003 - "In this study, the authors sought to replicate the findings of reduced synaptosomal associated protein 25 kDa (SNAP-25) immunoreactivity in the hippocampus of patients with schizophrenia. " 11/10/2019 - "Reduced SNAP25 Protein Fragmentation Contributes to SNARE Complex Dysregulation in Schizophrenia Postmortem Brain." 06/15/2003 - "We previously demonstrated increased synaptosomal associated protein, 25 kDa (SNAP-25), a member of the exocytotic mechanism, in the cerebrospinal fluid (CSF) of schizophrenia subjects. " 10/05/2009 - "Synaptosomal Associated Protein 25 kDa (SNAP25) has been implicated in the pathogenesis of schizophrenia by numerous neuropathological studies and genetic variation at SNAP25 has been reported to be associated with ADHD. " 11/01/2008 - "Several post mortem studies revealed a reduction of SNAP-25 protein in the hippocampus of patients with schizophrenia and bipolar disorder (BD). "
3.	Alzheimer Disease (Alzheimer's Disease) 01/01/2022 - "Several studies have shown increased levels of cerebrospinal fluid (CSF) synaptosomal-associated protein 25 (SNAP-25) in patients with Alzheimer's disease (AD). " 01/01/2022 - "Cerebrospinal Fluid Synaptosomal-Associated Protein 25 Levels in Patients with Alzheimer's Disease: A Meta-Analysis." 11/01/2006 - "Neuronal differentiation is accompanied by increased levels of SNAP-25 protein in fetal rat primary cortical neurons: implications in neuronal plasticity and Alzheimer's disease." 01/01/2018 - "Cerebrospinal fluid synaptosomal-associated protein 25 is a key player in synaptic degeneration in mild cognitive impairment and Alzheimer's disease." 04/01/1999 - "Decreased levels of synaptosomal associated protein 25 in the brain of patients with Down syndrome and Alzheimer's disease."
4.	Down Syndrome (Down's Syndrome) 01/16/2003 - "In a previous paper we have shown reduced amounts of SNAP-25 protein in adult Down Syndrome (DS) brain. " 04/01/1999 - "Decreased levels of synaptosomal associated protein 25 in the brain of patients with Down syndrome and Alzheimer's disease." 01/01/2021 - "CSF samples obtained from adults with Down syndrome, similarly aged carriers of autosomal dominant Alzheimer's disease mutations, and non-carrier siblings (aged 30-61 years) were analysed for markers of amyloid β (Aβ1-40, Aβ1-42); tau phosphorylated at threonine 181-related processes; neuronal, axonal, or synaptic injury (total tau, visinin-like protein 1, neurofilament light chain [NfL], synaptosomal-associated protein 25); and astrogliosis and neuroinflammation (chitinase-3-like protein 1 [YKL-40]) via immunoassay. " 01/01/2020 - "CSF concentrations of amyloid beta (Aβ)40, Aβ42, tau, phospho-tau181 (p-tau), neurofilament light chain (NfL), soluble triggering receptor expressed on myeloid cells 2 (sTREM2), chitinase-3-like protein 1 (YKL-40), alpha synuclein (αSyn), neurogranin (Ng), synaptosomal-associated protein 25 (SNAP-25), and visinin-like protein 1 (VILIP-1) were assessed in CSF from 44 adults with DS from the Alzheimer's Biomarker Consortium-Down Syndrome study. "
5.	Mental Disorders (Mental Disorder) 10/25/2017 - "Recent studies have accumulated evidence that the SNARE complex, and more specifically the SNAP25 protein, may be involved in psychiatric disorders. " 01/01/2013 - "Polymorphic variants of the SNAP-25 gene emerged as putative genetic components of impulsivity, as SNAP-25 protein plays an important role in the central nervous system, and its SNPs are associated with several psychiatric disorders. "

Related Drugs and Biologics

1.	Neurogranin
2.	Biomarkers (Surrogate Marker)
3.	Chitinase-3-Like Protein 1
4.	Dopamine Plasma Membrane Transport Proteins (Dopamine Transporter)
5.	Neurocalcin
6.	Methylphenidate (Ritalin)
7.	visinin
8.	alpha-Synuclein
9.	Dopamine D5 Receptors
10.	Dopamine D4 Receptors (Dopamine D4 Receptor)

Related Therapies and Procedures

1.	Lasers (Laser)