Compression Fractures (Compression Fracture)

Crumbling or smashing of cancellous BONE by forces acting parallel to the long axis of bone. It is applied particularly to vertebral body fractures (SPINAL FRACTURES). (Blauvelt and Nelson, A Manual of Orthopedic Terminology, 1994, p4)

Also Known As:

Networked: 1271 relevant articles (186 outcomes, 163 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Pain (Aches)
2.	Osteoporosis
3.	Neoplasm Metastasis (Metastasis)
4.	Multiple Myeloma
5.	Neoplasms (Cancer)

Experts

1.	Yang, Huilin: 17 articles (08/2015 - 01/2010)
2.	Kallmes, D F: 15 articles (04/2015 - 11/2000)
3.	Chen, Wen-Jer: 14 articles (01/2014 - 11/2003)
4.	Lai, Po-Liang: 12 articles (01/2014 - 11/2003)
5.	Chen, Liang: 12 articles (01/2013 - 11/2004)
6.	Gilula, Louis A: 12 articles (03/2010 - 04/2002)
7.	Kallmes, David F: 11 articles (01/2015 - 04/2002)
8.	Chen, Lih-Huei: 11 articles (01/2014 - 11/2003)
9.	Masala, Salvatore: 10 articles (07/2014 - 01/2004)
10.	Hirsch, Joshua A: 10 articles (09/2011 - 01/2003)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Compression Fractures:

1.	Polymethyl Methacrylate (Sol)IBA 01/01/2015 - "The purpose of this prospective multicentric observational study was to confirm the safety and clinical performance of a craniocaudal expandable implant used in combination with high viscosity PMMA bone cement for the treatment of vertebral compression fractures. " 01/30/2015 - "[Treatment of osteoporotic vertebral compression fractures with PMMA-augmented pedicle screw fixation]." 02/15/2014 - "Minimally invasively vertebral augmentation techniques with PMMA are mostly performed for treating osteoporotic compression fractures. " 12/01/2013 - "Vertebral augmentation with PMMA is a widely applied treatment of vertebral osteoporotic compression fractures. " 06/01/2012 - "PVP involves the transpedicular injection of polymethylmethacrylate (PMMA) into the vertebral body for treatment of osteoporotic compression fractures. "
2.	calcium phosphateIBA 08/01/2004 - "Vertebral reconstruction with biodegradable calcium phosphate cement in the treatment of osteoporotic vertebral compression fracture using instrumentation." 04/01/2010 - "Therapeutic efficacy of injectable calcium phosphate cement in osteoporotic vertebral compression fractures: prospective nonrandomized controlled study at 6-month follow-up." 12/01/2009 - "This study was undertaken to investigate the radiologic and clinical outcomes of vertebroplasty with calcium phosphate (CaP) cement in patients with osteoporotic vertebral compression fractures. " 02/01/2014 - "Vertebroplasty using calcium phosphate in osteoporotic vertebral compression fractures: how to prevent heterotopic ossifications?" 12/01/2010 - "Percutaneous vertebroplasty for osteoporotic compression fractures using calcium phosphate cement."
3.	Calcitonin (Calcitonin, Eel)FDA LinkGeneric 06/01/2015 - "These results are in accordance with literature referring to the analgesic effect of calcitonin in the acute osteoporotic vertebral compression fracture. " 06/01/1980 - "Basal immunoreactive calcitonin (iCT) was measured with a sensitive radioimmunoassay (RIA) in 62 PM-OP women with compression fractures (CF) and in 28 normal age-matched women. " 10/01/2005 - "Calcitonin appears to be effective in the management of acute pain associated with acute osteoporotic vertebral compression fractures by shortening time to mobilization." 01/01/2012 - "We sought to determine the analgesic efficacy of calcitonin for acute and chronic pain of osteoporotic vertebral compression fractures (OVCF). " 10/01/2005 - "Randomized, double-blind, placebo-controlled trials comparing calcitonin versus placebo for the acute pain of recent osteoporotic vertebral compression fractures were included. "
4.	cytidylyl-(3'-5')-cytidine (CpC)IBA 06/01/2007 - "They suggest that the use of CPC in vertebrae with compression fractures should be reconsidered." 08/01/2004 - "Vertebral reconstruction with biodegradable CPC in the treatment of osteoporotic vertebral compression fracture using instrumentation was a safe and useful surgical treatment." 04/01/2010 - "A prospective nonrandomized controlled study was performed to assess the clinical and radiologic results after balloon kyphoplasty with Callos CPC in osteoporotic vertebral compression fractures. " 06/01/2014 - "Evaluation of a 10-year follow-up with radiological and computed tomography results, calculated by 2 independent radiologists, VAS, Roland Morris score, Oswestry Disability Index (ODI) score and Denis work scale and clinical examination in patients with traumatic compression fractures type A, who were treated with a balloon kyphoplasty with CPC (Calcibon™ from Biomed). " 04/01/2010 - "Subsequent loss of augmentation properties during follow-up is a serious problem of kyphoplasty using injectable CPC in osteoporotic vertebral compression fractures. "
5.	TitaniumIBA 01/01/2015 - "The efficacy of a percutaneous expandable titanium device in anatomical reduction of vertebral compression fractures of the thoracolumbar spine." 01/01/2015 - "To evaluate the feasibility of a minimally invasive technique using a titanium expandable device to achieve anatomical restoration of vertebral compression fractures (VCF) of the thoracolumbar spine. " 04/01/2014 - "Determining whether implantation of an expandable titanium mesh cage (Osseofix® system) is a successful and safe minimally invasive therapy for osteoporotic and tumorous vertebral compression fractures (VCFs). " 09/01/2010 - "To evaluate differences in biomechanical stability of vertebral compression fractures repaired using balloon kyphoplasty versus a titanium mesh implant. " 09/01/2010 - "Biomechanical comparison of kyphoplasty versus a titanium mesh implant with cement for stabilization of vertebral compression fractures."
6.	Bupivacaine (Bupivacaine Hydrochloride)FDA LinkGeneric 10/01/2010 - "Nineteen patients with painful osteoporotic vertebral compression fractures underwent unblinded injection of lidocaine and bupivacaine at the site of painful osteoporotic vertebral compression fractures. " 10/01/2010 - "LABEL is a trial determining the efficacy of pain relief of an injection of lidocaine and bupivacaine at the site of painful osteoporotic vertebral compression fractures in unblinded patients. " 07/01/1999 - "Continuous intrathecal infusion of bupivacaine, with or without buprenorphine, appeared to be an effective method for the long-term treatment (months to > 1 year) of "refractory" pain from vertebral compression fractures, in this small group of patients." 07/01/1999 - "Intrathecal infusion of bupivacaine with or without buprenorphine relieved intractable pain in three patients with vertebral compression fractures caused by osteoporosis."
7.	CORTOSSIBA 09/15/2010 - "Forty patients were enrolled in 2 FDA-approved pilot Investigational Device Exemption (IDE) studies using Cortoss for the treatment of vertebral compression fractures (VCF). " 09/15/2010 - "Clinical experience using Cortoss for treating vertebral compression fractures with vertebroplasty and kyphoplasty: twenty four-month follow-up." 12/01/2005 - "These results indicate that vertebral augmentation with Cortoss rapidly reduces pain, decreases disability, and improves physical functioning in patients with painful vertebral compression fractures." 04/01/2012 - "To determine the safety and efficacy of a new, nonresorbable bioactive composite (Cortoss) compared with PMMA, the standard treatment of vertebral compression fractures (VCFs). " 01/01/2013 - "Two injectable materials for the treatment of vertebral compression fractures, Cortoss and PMMA, were compared in a prospective, randomized study. "
8.	AlloysIBA 01/01/2014 - "The aim of this study was to evaluate the feasibility of treating vertebral compression fractures using an autonomously developed nitinol memory alloy vertebral stent. " 01/01/2014 - "The nitinol memory alloy stents can effectively support and reduce the compression of vertebral endplates and can be used to treat vertebral compression fractures without neurological symptoms." 01/01/2015 - "The implantation of a Nickel-Titanium shape memory alloy ameliorates vertebral body compression fractures: a cadaveric study." 01/01/2015 - "To evaluate the effect of a Nickel-Titanium (Ni-Ti) shape memory alloy in the treatment of vertebral body compression fractures. "
9.	NickelIBA 01/01/2015 - "The implantation of a Nickel-Titanium shape memory alloy ameliorates vertebral body compression fractures: a cadaveric study." 01/01/2015 - "To evaluate the effect of a Nickel-Titanium (Ni-Ti) shape memory alloy in the treatment of vertebral body compression fractures. "
10.	Lidocaine (Xylocaine)FDA LinkGeneric 10/01/2010 - "Nineteen patients with painful osteoporotic vertebral compression fractures underwent unblinded injection of lidocaine and bupivacaine at the site of painful osteoporotic vertebral compression fractures. " 10/01/2010 - "LABEL is a trial determining the efficacy of pain relief of an injection of lidocaine and bupivacaine at the site of painful osteoporotic vertebral compression fractures in unblinded patients. "

Therapies and Procedures

1.	Vertebroplasty 12/01/2002 - "Percutaneous vertebroplasty has been performed in the United States since 1995, and widespread application of the procedure for osteoporotic and neoplastic compression fractures or vertebral infiltration has demonstrated remarkable efficacy with rare complications. " 09/01/2011 - "Percutaneous vertebroplasty is an effective treatment of painful osteoporotic compression fractures, minimally invasive and with very low morbidity, which is very useful to improve quality of life in these patients. " 12/01/2004 - "Percutaneous vertebroplasty can be very beneficial for patients with vertebral osteoporotic compression fractures. " 02/06/2002 - "Vertebroplasty is a very promising, effective and safe method for the treatment for osteoporotic vertebral compression fractures. " 01/01/2015 - "Computed tomography revealed a wedge-shaped osteoporotic compression fracture of T10 vertebrae, which was treated successfully with the installation of vertebral stenting system and vertebroplasty with methacrylate guided with a rotational interventional imaging system. "
2.	Kyphoplasty 12/01/2006 - "Vertebral height restoration in osteoporotic compression fractures: kyphoplasty balloon tamp is superior to postural correction alone." 05/01/2012 - "The objective of this study was to determine whether the Kiva system is as effective as balloon kyphoplasty at restoring mechanical properties in osteoporotic vertebral compression fractures. " 09/01/2014 - "The percutaneous kyphoplasty is an effective treatment for osteoporotic vertebral compression fractures. " 05/05/2007 - "Percutaneous kyphoplasty (PKP) using balloon expander has been proved to be effective in the treatment of painful vertebral compression fractures. " 07/01/2003 - "Kyphoplasty is an effective treatment for vertebral compression fractures. "
3.	Minimally Invasive Surgical Procedures 10/15/2006 - "The recent development of minimally invasive surgical procedures such as kyphoplasty allows patients with myeloma with vertebral compression fractures to have immediate improvement in their quality of life with shorter hospital stays. " 07/01/2014 - "For more than 30 years, minimally invasive surgical procedures have been available to stabilize the fractured vertebrae by cement augmentation leading to significant pain relief, a distinct improvement in quality of life and decreased mortality for patients suffering from osteoporotic vertebral compression fractures. " 07/01/2006 - "The development of minimally invasive surgical procedures such as kyphoplasty and vertebroplasty allows myeloma patients with vertebral compression fractures to have immediate improvement in quality of life and shorter hospital stays. " 02/01/2006 - "Vertebroplasty (VP) and kyphoplasty (KP) are minimally invasive surgical procedures that have recently been introduced for the medical management of osteoporosis-induced vertebral compression fractures. " 02/01/2003 - "New drugs to treat osteoporosis, along with two new minimally invasive surgical procedures, are important options for preventing vertebral compression fractures and treating severe back pain and disability. "
4.	Injections 11/01/2010 - "We present a small case series of patients with thoracic compression fractures managed with intra-articular facet injections. " 12/01/2008 - "These results showed that the new injectable IM-CPCs have cytocompatible features of interest to the intended kyphophasty application, for the treatment of osteoporotic vertebral compression fractures." 01/01/2004 - "A synthetic test model was developed to assist in screening injectable cements with a focus on mechanical strength for vertebral body compression fracture repair. " 04/01/2010 - "Therapeutic efficacy of injectable calcium phosphate cement in osteoporotic vertebral compression fractures: prospective nonrandomized controlled study at 6-month follow-up." 11/01/2012 - "Osteoporotic vertebral compression fracture augmentation by injectable partly resorbable ceramic bone substitute (Cerament™|SPINESUPPORT): a prospective nonrandomized study."
5.	Activities of Daily Living (ADL) 12/01/2012 - "Fifteen patients recovered from vertebral compression fracture and regained their preinjury activities of daily living. " 06/01/2010 - "This condition is associated with low bone mass, vertebral compression fractures, and degenerative disc disease, and contributes to difficulty performing activities of daily living and decline in physical performance. " 04/19/2008 - "To determine, on the basis of the available literature, whether kyphoplasty is a safe technique for the treatment of osteoporotic vertebral compression fractures that leads to functional improvement in the patient's activities of daily living. " 01/01/1993 - "Osteoporotic compression fractures of the spine differ from most other age-related fractures in that they usually are associated with minimal trauma and with loads no greater than those encountered during normal activities of daily living. " 01/01/2008 - "There is a risk that disturbances of activities of daily living (ADL) due to rheumatoid arthritis (RA) are increased by the occurrence of fractures, including vertebral compression fractures and femoral neck fractures, in RA patients receiving oral corticosteroid therapy. "