Compression Fractures (Compression Fracture)

Crumbling or smashing of cancellous BONE by forces acting parallel to the long axis of bone. It is applied particularly to vertebral body fractures (SPINAL FRACTURES). (Blauvelt and Nelson, A Manual of Orthopedic Terminology, 1994, p4)

Also Known As:

Networked: 2597 relevant articles (314 outcomes, 415 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Pain (Aches)
2.	Osteoporosis
3.	Neoplasms (Cancer)
4.	Back Pain (Backache)
5.	Multiple Myeloma

Experts

1.	Yang, Huilin: 33 articles (01/2022 - 01/2010)
2.	Hirsch, Joshua A: 19 articles (09/2022 - 01/2003)
3.	Kallmes, David F: 18 articles (01/2020 - 04/2002)
4.	Kallmes, D F: 16 articles (12/2016 - 11/2000)
5.	Lai, Po-Liang: 15 articles (01/2022 - 11/2003)
6.	Chen, Wen-Jer: 14 articles (01/2014 - 11/2003)
7.	Chen, Liang: 13 articles (10/2017 - 11/2004)
8.	Gilula, Louis A: 13 articles (03/2010 - 04/2002)
9.	Masala, Salvatore: 12 articles (09/2017 - 01/2004)
10.	Chen, Lih-Huei: 11 articles (01/2014 - 11/2003)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Compression Fractures:

1.	Polymethyl Methacrylate (Sol)IBA 09/01/2021 - "PVP is also an effective treatment for osteoporotic vertebral compression fracture that mainly involves a percutaneous injection of polymethylmethacrylate. " 11/01/2023 - "Injection of a PMMA-doped MSC spheroid gel for the treatment of painful osteoporotic vertebral compression fractures." 10/01/2020 - "The acute complication according to PMMA such as leakage and embolization was none, but adjacent compression fracture as late complication according to cement augmentation was. " 02/15/2014 - "Minimally invasively vertebral augmentation techniques with PMMA are mostly performed for treating osteoporotic compression fractures. " 12/01/2013 - "Vertebral augmentation with PMMA is a widely applied treatment of vertebral osteoporotic compression fractures. "
2.	Bone Cements (Bone Glue)IBA 03/01/2023 - "Both PCVP and bilateral PVP are safe and effective methods for the treatment of osteoporotic vertebral compression fractures, but PCVP has a short operation time, fewer fluoroscopy times, and a low bone cement leakage rate." 12/01/2010 - "In the management of even long-standing osteoporotic vertebral compression fracture for over one year, bone cement augmentation procedures following postural reduction were considered safe and effective treatment in cases of non-healing evidence." 01/01/2022 - "The aim of this study was to investigate the effect of unilateral and bilateral bone cement distribution on the clinical efficacy of PVP in the treatment of osteoporotic vertebral compression fractures (OVCF) of the thoracolumbar spine. " 01/01/2022 - "The objective of this study was to identify the different outcomes between high-viscosity bone cement (HVBC) and low-viscosity bone cement (LVBC) used to repair mid (T7-9)- and high (T4-6)- thoracic vertebral compression fractures. " 12/01/2019 - "The study included 72 patients with osteoporotic vertebral compression fractures with intravertebral cleft, who were divided into high-viscosity cement (HVC) (38 cases) and low-viscosity cement (LVC) (34 cases) groups according to the viscosity of bone cement used. "
3.	Zoledronic Acid (Zometa)FDA Link 01/01/2021 - "Clinical Efficacy and Safety of Zoledronic Acid Combined with PVP/PKP in the Treatment of Osteoporotic Vertebral Compression Fracture: A Systematic Review and Meta-Analysis of Randomized Controlled Trials." 07/01/2023 - "To explore the therapeutic efficacy of percutaneous kyphoplasty (PKP) combined with zoledronic acid (ZOL) in postmenopausal women and adult men with osteoporotic vertebral compression fracture (OVCF). " 07/01/2021 - "This study investigated the efficacy of annual zoledronic acid (ZOL) administration against previously treated recompression vertebral fractures (RVF) and new vertebral fractures (NVF) in initial percutaneous kyphoplasty (PKP) patients with osteoporotic vertebral compression fractures (OVCF) over a 3-year follow-up period. " 07/01/2021 - "Efficacy of annual zoledronic acid in initial percutaneous kyphoplasty patients with osteoporotic vertebral compression fractures: a 3-year follow-up study." 01/01/2022 - "This study was designed to help elucidate the benefits and advantages of vertebroplasty combined with zoledronic acid (ZOL) versus vertebroplasty alone, to provide clinical recommendations for the treatment of osteoporotic vertebral compression fractures (OVCFs) considering the current best-available evidence. "
4.	Analgesics (Analgesic Drugs)IBA 01/01/2018 - "The clinical effects of both PKP and PVP in the treatment of osteoporotic vertebral compression fractures are good, of which the reductive and analgesic effect of PKP is superior to that of PVP and the former has less leakage of cement, higher safety and fewer complications." 09/01/1995 - "Lastly, its analgesic efficacy in cases of painful vertebral compression fractures has been demonstrated in controlled studies." 05/01/2012 - "Elderly patients with painful osteoporotic vertebral compression fractures were all treated with 6 weeks of conservative care (analgesics, bracing, and physiotherapy). " 09/01/2006 - "Acute osteoporotic vertebral compression fracture management includes bracing, analgesics, and functional restoration. " 01/01/2006 - "The purpose of the present study was to ascertain chronological changes in the analgesic effects of percutaneous vertebroplasty (PVP) on osteoporotic vertebral compression fractures and to radiologically follow new compression fractures after PVP. "
5.	calcium phosphateIBA 08/01/2004 - "Vertebral reconstruction with biodegradable calcium phosphate cement in the treatment of osteoporotic vertebral compression fracture using instrumentation." 04/01/2010 - "Therapeutic efficacy of injectable calcium phosphate cement in osteoporotic vertebral compression fractures: prospective nonrandomized controlled study at 6-month follow-up." 12/01/2009 - "This study was undertaken to investigate the radiologic and clinical outcomes of vertebroplasty with calcium phosphate (CaP) cement in patients with osteoporotic vertebral compression fractures. " 08/05/2022 - "Co-citation analysis of the key words indicated that the top 5 focus areas were "complication," "balloon kyphoplasty," "vertebral compression fracture," "biomechanics," and "calcium phosphate cement." The top 3 keywords with the strongest citation bursts were "compression fracture," "cement," and "balloon kyphoplasty." The keywords with persistent strong citation bursts are "balloon kyphoplasty" and "augmentation." There are still contrary opinions about vertebral augmentation; new research should be conducted with more deliberate design and longer follow-up." 02/01/2014 - "Vertebroplasty using calcium phosphate in osteoporotic vertebral compression fractures: how to prevent heterotopic ossifications?"
6.	Calcitonin (Calcitonin, Eel)FDA LinkGeneric 06/01/1980 - "Basal immunoreactive calcitonin (iCT) was measured with a sensitive radioimmunoassay (RIA) in 62 PM-OP women with compression fractures (CF) and in 28 normal age-matched women. " 10/01/2005 - "Calcitonin appears to be effective in the management of acute pain associated with acute osteoporotic vertebral compression fractures by shortening time to mobilization." 01/01/2020 - "Efficacy of calcitonin for treating acute pain associated with osteoporotic vertebral compression fracture: an updated systematic review." 10/01/2005 - "Randomized, double-blind, placebo-controlled trials comparing calcitonin versus placebo for the acute pain of recent osteoporotic vertebral compression fractures were included. " 10/01/2005 - "Calcitonin for treating acute pain of osteoporotic vertebral compression fractures: a systematic review of randomized, controlled trials."
7.	Diphosphonates (Bisphosphonates)IBA 01/01/2022 - "To explore the effect of bisphosphonates after vertebroplasty in patients with osteoporotic vertebral compression fractures (OVCF), and to analyze the relationship between the use of bisphosphonates and vertebral refracture. " 10/01/2014 - "Risk Factors of New Adjacent Compression Fracture after Percutaneous Vertebroplasty: Effectiveness of Bisphosphonate in Osteoporotic or Osteopenic Elderly Patients." 02/01/2005 - "If the T-score reaches a level of >2.5, or if it is between -1.5 and -2.5 in the presence of a fragility fracture or vertebral compression fracture, or if height loss > 2 cm occurs or BMD decreases > 3% in 1 year at the lumbar spine or > 5% at the femoral neck, bisphosphonate therapy should be considered." 02/01/2023 - "Treatment of compression fractures with bisphosphonates resulted in resolution of back pain and improved bone density." 01/01/2021 - "Bisphosphonate use was also shown to significantly reduce the likelihood of postoperative vertebral compression fracture (VCF; OR 0.07, 95% CI 0.01-0.59, p = 0.01) and significantly reduce Oswestry Disability Index scores (mean difference [MD] = -2.19, 95% CI -2.94 to -1.44, p < 0.00001) and visual analog scale pain scores (MD = -0.58, 95% CI -0.79 to -0.38, p < 0.00001). "
8.	Therapeutic UsesIBA 01/01/2021 - "Comparison of Therapeutic Effects of PVP and PKP Combined With Triple Medication on Mild and Moderate Osteoporotic Vertebral Compression Fracture in the Elderly." 04/01/2017 - "The therapeutic effect of intravertebral vacuum cleft with osteoporotic vertebral compression fractures: A systematic review and meta-analysis." 01/01/2015 - "Therapeutic effects of PKP on chronic painful osteoporotic vertebral compression fractures with or without intravertebral cleft." 01/01/2017 - "To explore the efficacy of secondary balloon kyphoplasty (BKP) for new vertebral compression fracture (NVCF) of previously non-fractured, non-treated vertebrae after previous BKP and to compare the therapeutic effect between patients with single-level adjacent NVCF and remote NVCF. " 11/01/2019 - "Therapeutic effect of kyphoplasty and balloon vertebroplasty on osteoporotic vertebral compression fracture: A systematic review and meta-analysis of randomized controlled trials."
9.	Teriparatide (Parathar)FDA Link 01/01/2020 - "The Application of Vertebral Augmentation Procedures and Teriparatide in the Treatment of Osteoporotic Vertebral Compression Fractures [Response to Letter]." 04/01/2019 - "Can Three Months of Teriparatide Be One of Treatment Options for Osteoporotic Vertebral Compression Fracture Patients?" 01/01/2019 - "Could Teriparatide Replace Percutaneous Vertebral Augmentation for Patients with Osteoporotic Vertebral Compression Fracture to Some Extent? " 10/01/2016 - "Although the period of teriparatide treatment has been relatively short, the preventive effects of compression fracture were considerable. " 07/01/2015 - "Herein, we report a case with severe PLO and multiple vertebral compression fractures that were successfully treated with teriparatide. "
10.	TitaniumIBA 01/01/2015 - "The efficacy of a percutaneous expandable titanium device in anatomical reduction of vertebral compression fractures of the thoracolumbar spine." 01/01/2023 - "Titanium implantable vertebral augmentation device (TIVAD) are regarded as having potential in the treatment of vertebral compression fractures (VCFs). " 05/21/2019 - "Treatment of a High-risk Thoracolumbar Compression Fracture Using Bilateral Expandable Titanium SpineJack Implants." 01/01/2015 - "To evaluate the feasibility of a minimally invasive technique using a titanium expandable device to achieve anatomical restoration of vertebral compression fractures (VCF) of the thoracolumbar spine. " 06/21/2023 - "(1) Background: to retrospectively evaluate safety and efficacy of combined microwave ablation (MWA) and bilateral expandable titanium SpineJack (SJ) implants followed by vertebroplasty (VP) for the treatment of painful thoracolumbar pathological vertebral compression fracture. "

Therapies and Procedures

1.	Vertebroplasty 12/01/2002 - "Percutaneous vertebroplasty has been performed in the United States since 1995, and widespread application of the procedure for osteoporotic and neoplastic compression fractures or vertebral infiltration has demonstrated remarkable efficacy with rare complications. " 09/01/2011 - "Percutaneous vertebroplasty is an effective treatment of painful osteoporotic compression fractures, minimally invasive and with very low morbidity, which is very useful to improve quality of life in these patients. " 12/01/2004 - "Percutaneous vertebroplasty can be very beneficial for patients with vertebral osteoporotic compression fractures. " 02/06/2002 - "Vertebroplasty is a very promising, effective and safe method for the treatment for osteoporotic vertebral compression fractures. " 01/01/2008 - "The use of vertebroplasty with cement to treat multiple-level osteoporotic spinal compression fractures in the elderly does have value, and brings good results to patients which were previously unimaginable. "
2.	Kyphoplasty 01/01/2016 - "In patients with osteoporotic vertebral compression fractures (VCFs), both SpineJack® (SJ) and balloon kyphoplasty (BKP) led to a rapid and marked improvement in clinical signs. " 01/01/2022 - "Osteoporotic vertebral compression fractures can be successfully treated with percutaneous kyphoplasty. " 12/01/2017 - "Balloon kyphoplasty is a widely accepted treatment of osteoporotic vertebral compression fractures (OVCFs) with good results and a low risk for complications. " 12/01/2006 - "Vertebral height restoration in osteoporotic compression fractures: kyphoplasty balloon tamp is superior to postural correction alone." 05/01/2012 - "The objective of this study was to determine whether the Kiva system is as effective as balloon kyphoplasty at restoring mechanical properties in osteoporotic vertebral compression fractures. "
3.	Conservative Treatment 04/01/2021 - "The study was conducted on a consecutive series of 54 patients with symptomatic vertebral compression fractures who failed conservative management between 2014 and 2017. " 01/01/2020 - "This study aimed to determine the factors independently associated with the subsequent vertebral compression fracture (VCF) after hospital conservative therapy in patients with new fragility VCFs and parameters related with functional recovery in the acute period. " 01/01/2019 - "This study aimed to identify risk factors for failure of conservative treatment of acute osteoporotic vertebral compression fractures (OVCFs). " 05/01/2023 - "To investigate whether dynamic fracture mobility could affect the outcome of conservative treatment in patients with acute osteoporotic vertebral compression fracture (OVCF). " 05/01/2023 - "A Retrospective Study to Evaluate the Role of Dynamic Fracture Mobility in the Conservative Treatment of Osteoporotic Vertebral Compression Fractures."
4.	Therapeutics 02/01/1988 - "Complete remission of ALL was induced in all patients, and symptoms of vertebral compression fractures abated following antileukemia therapy. " 05/01/1988 - "Such therapy is particularly beneficial for prevention of spinal compression fractures; in addition, it alleviates menopausal symptoms (hot flushes, genitourinary symptoms, and changes in mood). " 01/01/2017 - " therapy was considered the gold standard for treating osteoporotic vertebral compression fractures (OVCFs) in the past. " 06/01/2007 - "Twenty-one patients have been enrolled in a prospective nonrandomized controlled study with painful vertebral compression fractures resistant to common therapies. " 01/01/1993 - "The prevalence of radiographic vertebral compression fractures (VCF) reached 26% in a rigorous population study of men and women more than 50 years old.1 However, only an estimated 8% of the total affected population actually seek medical attention.2-4 Investigations of effective medical therapy have been extensive, while sound studies of the physical therapeutic measures have been relatively few.5-10Pain and loss of functional mobility result from this disorder. "
5.	Punctures 01/01/2022 - "Both preoperatively designed precise unilateral puncture pathways and traditional unilateral puncture procedures PVP are reasonably safe and effective for individuals with painful osteoporotic spinal compression fractures. " 01/01/2022 - "Comparison of the clinical and radiological effects of precise unilateral puncture pathway prepared by preoperative CT data and traditional unilateral puncture pathway in PVP administration for the treatment of osteoporotic vertebral compression fractures. " 07/01/2021 - "Unilateral and bilateral puncture PKP can achieve good clinical efficacy in the treatment of osteoporotic vertebral compression fractures, but unilateral PKP has the advantages of short operation time and low X-ray exposure." 12/05/2019 - "A second puncture and injection technique for treating osteoporotic vertebral compression fractures." 06/25/2019 - "Backward rotation method can theoretically meet the requirements of puncture point for vertebral compression fracture, especially for males and lower lumbar spine. "