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Split-Brain Procedure (Split-Brain)

Complete severing of the CORPUS CALLOSUM. In humans it is usually performed to treat medically intractable, multifocal EPILEPSY. EXPERIMENTAL ANIMAL MODELS of split brain preparations are used in research.
Also Known As:
Split-Brain; Procedures, Split-Brain; Split Brain; Split Brain Procedure; Split-Brain Procedures
Networked: 43 relevant articles (2 outcomes, 7 trials/studies)

Relationship Network

Therapy Context: Research Results

Experts

1. Zaidel, Eran: 3 articles (06/2019 - 02/2003)
2. Fabri, Mara: 2 articles (01/2021 - 01/2020)
3. Foschi, Nicoletta: 2 articles (01/2021 - 01/2020)
4. Pinto, Yair: 2 articles (01/2021 - 01/2020)
5. de Haan, Edward H F: 2 articles (01/2021 - 01/2020)
6. Uddin, Lucina Q: 2 articles (06/2019 - 09/2005)
7. Blihar, David: 1 article (01/2021)
8. Du Plessis, Maira: 1 article (01/2021)
9. Huang, Richard: 1 article (01/2021)
10. Loukas, Marios: 1 article (01/2021)

Related Diseases

1. Seizures (Absence Seizure)
01/01/2021 - "Sperry's split-brain studies inspired surgeons to reexamine the role of corpus callosotomy in the control of epileptic seizures. "
03/01/1985 - "To the extent that these observations also apply to the interhemispheric fibers of the human hippocampal formation and parahippocampal areas, their possible preservation must be considered when interpreting the effect of callosal transection on seizures and the results of "split-brain" studies, since callosal transection may fail to sever the hippocampal commissures in their entirety."
05/01/1974 - "[Bioelectric development of focal and epileptic seizures in split-brain cats]."
05/01/1970 - "Interhemispheric commissurotomy: (the split brain operation) as an alternate to hemispherectomy for control of intractable seizures."
10/15/2020 - "This is a surgical technique video of selective posterior callosotomy (SPC), a novel surgical procedure to alleviate refractory epileptic drop attacks.1 Departing from traditional approaches aiming the anterior half or the entire callosum, SPC sections the posterior half of the callosum sparing prefrontal connectivity.1 Drop attacks are generalized epileptic seizures characterized by sudden falls.1 These seizures are often seen in diffuse brain pathology associated with generalized or multifocal epilepsies, whose electroencephalogram (EEG) "fingerprint" is bilaterally synchronous epileptic discharges.1 Sectioning the callosum to control drop attacks follows the rationale that the rapid synchronization of discharges between motor and premotor regions of both hemispheres is the basis.1 The standard approach to callosotomies always contemplated the anterior fibers of the callosum.2 Literature reports that anterior sections lead to unsatisfactory control of drop attacks, and results are improved when extended into a total callosotomy.2,3 This evidence coupled with diffusion tensor imaging (DTI) findings showing that motor and premotor fibers actually cross through posterior half of the callosum led us to hypothesize that selective section of the posterior half of the callosum would section all relevant motor fibers and control drop attacks to a similar extent to total callosotomies, with the advantage of sparing prefrontal interconnectivity3 and no split-brain syndrome. "
2. Epilepsy (Aura)
12/01/1999 - "Many investigations have been carried out on lateralization, mainly in relation to specific pathologies (i.e., epilepsy, split-brain, lobotomy, etc.), while there have been few studies of healthy subjects. "
01/01/2020 - "In 'split-brain' patients, the corpus callosum has been surgically severed to alleviate medically intractable, severe epilepsy. "
10/15/2020 - "This is a surgical technique video of selective posterior callosotomy (SPC), a novel surgical procedure to alleviate refractory epileptic drop attacks.1 Departing from traditional approaches aiming the anterior half or the entire callosum, SPC sections the posterior half of the callosum sparing prefrontal connectivity.1 Drop attacks are generalized epileptic seizures characterized by sudden falls.1 These seizures are often seen in diffuse brain pathology associated with generalized or multifocal epilepsies, whose electroencephalogram (EEG) "fingerprint" is bilaterally synchronous epileptic discharges.1 Sectioning the callosum to control drop attacks follows the rationale that the rapid synchronization of discharges between motor and premotor regions of both hemispheres is the basis.1 The standard approach to callosotomies always contemplated the anterior fibers of the callosum.2 Literature reports that anterior sections lead to unsatisfactory control of drop attacks, and results are improved when extended into a total callosotomy.2,3 This evidence coupled with diffusion tensor imaging (DTI) findings showing that motor and premotor fibers actually cross through posterior half of the callosum led us to hypothesize that selective section of the posterior half of the callosum would section all relevant motor fibers and control drop attacks to a similar extent to total callosotomies, with the advantage of sparing prefrontal interconnectivity3 and no split-brain syndrome. "
01/01/2019 - "In the second part, we discuss different neuroscientific theories on consciousness and examine how research from developmental psychology, clinical neurology (epilepsy, coma, vegetative state and minimal state of consciousness), neuropsychology (blindsight, agnosia, neglect, split-brain and ocular rivalry), and comparative neuropsychophysiology contribute to the study of consciousness. "
08/01/1977 - "Cerebral commissurotomy or the "split-brain" procedure may be a valuable adjunct to anticonvulsants for the control of seizures in people whose epilepsy cannot be relieved by anticonvulsants alone, and who are not candidate for the standard methods of surgery. "
3. Syncope (Fainting)
10/15/2020 - "This is a surgical technique video of selective posterior callosotomy (SPC), a novel surgical procedure to alleviate refractory epileptic drop attacks.1 Departing from traditional approaches aiming the anterior half or the entire callosum, SPC sections the posterior half of the callosum sparing prefrontal connectivity.1 Drop attacks are generalized epileptic seizures characterized by sudden falls.1 These seizures are often seen in diffuse brain pathology associated with generalized or multifocal epilepsies, whose electroencephalogram (EEG) "fingerprint" is bilaterally synchronous epileptic discharges.1 Sectioning the callosum to control drop attacks follows the rationale that the rapid synchronization of discharges between motor and premotor regions of both hemispheres is the basis.1 The standard approach to callosotomies always contemplated the anterior fibers of the callosum.2 Literature reports that anterior sections lead to unsatisfactory control of drop attacks, and results are improved when extended into a total callosotomy.2,3 This evidence coupled with diffusion tensor imaging (DTI) findings showing that motor and premotor fibers actually cross through posterior half of the callosum led us to hypothesize that selective section of the posterior half of the callosum would section all relevant motor fibers and control drop attacks to a similar extent to total callosotomies, with the advantage of sparing prefrontal interconnectivity3 and no split-brain syndrome. "
4. Persistent Vegetative State (Vegetative State)
5. Schizophrenia (Dementia Praecox)

Related Drugs and Biologics

1. Anticonvulsants (Antiepileptic Drugs)
2. Serotonin (5 Hydroxytryptamine)
3. Tacrolimus (Prograf)

Related Therapies and Procedures

1. Operative Surgical Procedures
2. Psychosurgery (Lobotomy)
3. Hemispherectomy
4. Liver Transplantation
5. Surgical Amputation (Amputations)