STAT6 Transcription Factor

A signal transducer and activator of transcription that mediates cellular responses to INTERLEUKIN-4. Stat6 has been shown to partner with NF-KAPPA B and CCAAT-ENHANCER-BINDING PROTEINS to regulate GENETIC TRANSCRIPTION of interleukin-4 responsive GENES.

Also Known As:

Networked: 189 relevant articles (2 outcomes, 17 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Corry, David B: 4 articles (11/2018 - 01/2002)
2.	Kaplan, Mark H: 4 articles (04/2018 - 11/2011)
3.	Li, Feng: 3 articles (01/2020 - 03/2012)
4.	Brombacher, Frank: 3 articles (01/2019 - 01/2007)
5.	Kheradmand, Farrah: 3 articles (11/2018 - 01/2002)
6.	Travers, Jeffrey B: 3 articles (04/2018 - 01/2012)
7.	Wills-Karp, Marsha: 3 articles (01/2017 - 08/2006)
8.	Finkelman, Fred D: 3 articles (05/2007 - 08/2006)
9.	Rothenberg, Marc E: 3 articles (05/2007 - 02/2003)
10.	Salguero-Aranda, Carmen: 2 articles (07/2021 - 01/2019)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2022 - "The role of signal transducer and activator of transcription 6 (STAT6) in tumor growth has been widely recognized. " 10/23/2021 - "Histopathological examination of needle-core biopsies showed spindle cell neoplasm with small and fusiform cells, strongly expressing signal transducer and activator of transcription 6 (STAT6) with a ramifying vascular network. " 01/01/2021 - "Furthermore, several reports have shown specific NAB2-STAT6 fusion variants and loss of STAT6 protein expression are associated with malignancy. " 01/01/2020 - "To test the hypothesis that HT impacts PTC development via signal transducer and activator of transcription 6 (STAT6) activation and M2 macrophage polarization, we investigated STAT6 expression in tumor and stromal cells. " 03/01/2019 - "Hyperintensity on T2-weighted magnetic resonance imaging combined with positive immunohistochemical staining for signal transducer and activator of transcription 6 are important clues for classification and differentiation of these tumors. "
2.	Neoplasm Metastasis (Metastasis) 02/03/2003 - "Clearance of lung metastases by the Th2 cells was found to be totally dependent on the eosinophil chemokine, eotaxin, and partially dependent on the transcription activator signal transducer and activator of transcription 6 (STAT6), with degranulating eosinophils within the tumors inducing tumor regression. " 04/24/2023 - "Since M2-like tumor-associated macrophages (TAMs) that required activation of the signal transducer and activator of transcription 6 (STAT6) for polarization are the important immune cells in the tumor microenvironment and play a key role in tumor progress and metastasis, this study aimed to confirm whether Pulsatilla saponins could inhibit the development and metastasis of tumors by inhibiting the polarization of M2 macrophages. "
3.	Atopic Dermatitis (Atopic Eczema) 12/01/2022 - "Inhibiting Keratinocyte-Derived Signal Transducer and Activator of Transcription 6 Improved Atopic Dermatitis in Mice." 11/01/2011 - "The signal transducer and activator of transcription 6 gene (STAT6) increases the propensity of patients with atopic dermatitis toward disseminated viral skin infections." 04/01/2018 - "The Stat6VT mouse model of atopic dermatitis (AD) is induced by T-cell-specific expression of a constitutively active form of the protein signal transducer and activator of transcription 6 (STAT6). " 01/01/2016 - "To test this further, we crossed Kit(W-sh/W-sh) mice with signal transducer and activator of transcription 6 (i.e., Stat6) VT transgenic mice that develop spontaneous atopic dermatitis-like disease that is dependent on T helper cell 2 cytokines and is associated with high serum concentrations of IgE. "
4.	Asthma (Bronchial Asthma) 01/01/2020 - "These data suggest that Majie cataplasm exert an anti-inflammatory effect of Th2 by rebalancing Th1/Th2 through corresponding transcription factor STAT6, GATA-3, STAT3, and T-bet, which providing a strong cornerstone for asthma control." 03/02/2018 - "Transactivation of inflammatory and immune mediators in asthma is tightly regulated by nuclear factor κB (NF-κB) and signal transducer and activator of transcription 6 (STAT6). " 01/01/2013 - "Signal transducer and activator of transcription 6 polymorphism and asthma risk: a meta-analysis." 01/01/2011 - "The signal transducer and activator of transcription 6 (STAT6) expression in lung epithelial cells plays a pivotal role in asthma pathogenesis. " 09/01/2004 - "In this paper, we report for the first time the results of an investigation on the association of signal transducer and activator of transcription 6 (STAT6) with asthma in the Indian population. "
5.	Fibrosis (Cirrhosis) 11/06/2021 - "In the present study, we examine the role of signal transducer and activator of transcription 6 (STAT6) in myeloid fibroblast activation, macrophage polarization, and renal fibrosis development in a mouse model of folic acid nephropathy. " 09/02/2016 - "Although Rora is best known for its role in group 2 innate lymphoid cell (ILC2) development, we find that Salmonella-induced fibrosis is independent of eosinophils, signal transducer and activator of transcription 6 signaling, and T helper 2 cytokine production, arguing that this process is largely ILC2-independent. " 01/01/2017 - "Specifically, Interleukin-1 Receptor1 (IL-1R1) and Signal Transducer and Activator of Transcription 6 (STAT6) knock-out (KO) mice were employed to target inflammation and the subsequent healing response using MWCNTs as a model pro-fibrotic stressor to determine whether this altered the development of fibrosis. " 12/01/2023 - "In this study, we aimed to investigate the role of MMT in renal fibrosis in glyoxylate-induced kidney stone mice and the mechanism by which signal transducer and activator of transcription 6 (STAT6) regulates MMT. " 01/01/2019 - "When mice lacking signal transducer and activator of transcription 6 (STAT6), a transcription factor known to be important for the production and signaling of IL-4 and IL-13, were infected with CP1, fibrosis was attenuated. "

Related Drugs and Biologics

1.	Chemokines
2.	Interleukin-13
3.	Messenger RNA (mRNA)
4.	STAT6 Transcription Factor
5.	Interleukin-4 (Interleukin 4)
6.	Interleukin-4 Receptors (Interleukin 4 Receptor)
7.	Vimentin
8.	Aldehyde Dehydrogenase 1 Family
9.	Interleukin-33
10.	Nestin

Related Therapies and Procedures

1.	Therapeutics
2.	Electroacupuncture
3.	Radiotherapy