SUNCT Syndrome

A primary headache disorder that is characterized by frequent short-lasting, unilateral, neuralgiform pain attacks in the ocular area, with CONJUNCTIVA fluid-filling and tearing. SUNCT syndrome is usually resistant to treatment.

Also Known As:

Networked: 44 relevant articles (5 outcomes, 2 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Headache (Headaches)
2.	Headache Disorders (Headache Syndromes)
3.	Prolactinoma (Prolactinomas)
4.	Paroxysmal Hemicrania (Chronic Paroxysmal Hemicrania)
5.	Post-Traumatic Headache

Experts

1.	Goadsby, P J: 3 articles (10/2006 - 04/2002)
2.	Matharu, M S: 2 articles (11/2004 - 04/2002)
3.	Nappi, G: 2 articles (12/2003 - 11/2001)
4.	Berbel, A: 2 articles (06/2002 - 04/2002)
5.	Martinez-Salio, A: 2 articles (06/2002 - 04/2002)
6.	Benito-Leon, J: 2 articles (06/2002 - 04/2002)
7.	Porta-Etessam, J: 2 articles (06/2002 - 04/2002)
8.	Gay-Escoda, Cosme: 1 article (04/2015)
9.	Berini-Aytés, Leonardo: 1 article (04/2015)
10.	Camps-Font, Octavi: 1 article (04/2015)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to SUNCT Syndrome:

1.	lamotrigine (Lamictal)FDA LinkGeneric 09/01/2003 - "We concluded that lamotrigine is effective in treating SUNCT syndrome when used in high doses for a prolonged period of time." 01/01/2011 - "According to case reports and observational studies, lamotrigine therapy has resulted in decreased frequency or resolution of SUNCT syndrome attacks. " 01/01/2011 - "There is a lack of randomized placebo-controlled clinical trials evaluating lamotrigine in SUNCT syndrome therapy; however, 2 observational studies, 3 case series, and 5 case reports were reviewed. " 09/01/2003 - "Influence of lamotrigine over the SUNCT syndrome: one patient follow-up for two years." 07/01/2003 - "SUNCT syndrome responsive to lamotrigine: documentation of the first Indian case."
2.	gabapentin (Neurontin)FDA LinkGeneric 12/01/2008 - "This study was designed to evaluate the efficacy of gabapentin (GBP) in the treatment of SUNCT syndrome on a relatively large sample of Persian patients. " 12/01/2008 - "Efficacy of gabapentin in the treatment of SUNCT syndrome." 06/01/2007 - "[Gabapentin in the treatment of SUNCT syndrome]." 06/01/2002 - "Gabapentin in the treatment of SUNCT syndrome." 04/01/2002 - "Gabapentin (neuronetin) in the treatment of SUNCT syndrome."
3.	Lidocaine (Xylocaine)FDA LinkGeneric 01/01/2010 - "Intravenous lidocaine should be considered in all patients with SUNCT syndrome. " 01/01/2010 - "We report a patient with SUNCT syndrome who showed a clear-cut and consistent response to intravenous lidocaine therapy, which proved superior to placebo in a single-blinded fashion. " 01/01/2010 - "Response to intravenous lidocaine in a patient with SUNCT syndrome." 11/01/2004 - "SUNCT syndrome responsive to intravenous lidocaine." 11/01/2008 - "Intravenous lidocaine is a novel treatment for chronic daily headache with medication overuse and SUNCT syndrome. "
4.	topiramate (Topamax)FDA LinkGeneric 04/01/2015 - "Based on the anamnesis, clinical examination and a magnetic resonance imaging scan, episodic SUNCT syndrome was diagnosed and pharmacological treatment with topiramate was started. " 06/28/2005 - "SUNCT syndrome: a possible bilateral case responding to topiramate." 12/01/2003 - "SUNCT syndrome successfully treated with topiramate: case reports." 04/23/2002 - "SUNCT syndrome: prolonged attacks, refractoriness and response to topiramate." 02/01/2008 - "[SUNCT syndrome (short-lasting unilateral neuralgiform headache with conjuntival injection and tearing): a rare case in a paediatric patient with favourable response to topiramate]."
5.	oxcarbazepine (Trileptal)FDA LinkGeneric 09/01/2006 - "SUNCT syndrome with dramatic response to oxcarbazepine." 11/01/2009 - "SUNCT syndrome successfully treated with the combination of oxcarbazepine and gabapentin."
6.	Dopamine Agonists (Dopamine Agonist)IBA 03/01/2006 - "Short-lasting unilateral neuralgiform headache with conjunctival injection and tearing (SUNCT) syndrome may be associated with pituitary prolactinoma and may be induced by treatment of prolactinoma with dopamine agonists. "
7.	Biological Markers (Surrogate Marker)IBA 01/01/2010 - "Short-lasting unilateral neuralgiform headache with conjunctival injection and tearing (SUNCT) syndrome represents a serious therapeutic and diagnostic challenge, since it is usually refractory to most drugs and lacks biological markers. "
8.	Verapamil (Calan)FDA LinkGeneric 06/01/2005 - "A case of SUNCT syndrome responsive to verapamil."
9.	SteroidsIBA 02/01/2009 - "SUNCT syndrome responding absolutely to steroids in two cases with different etiologies."
10.	Pilocarpine (Ocusert)FDA LinkGeneric 04/01/1993 - "The forehead sweating pattern in SUNCT syndrome may differ from the patterns in unilateral headaches like cluster headache, on the one hand (in which there is generally an asymmetry during heating and pilocarpine tests), and chronic paroxysmal hemicrania (CPH) and cervicogenic headache, on the other (where there is no systematic increase during attacks."

Therapies and Procedures

1.	Surgical Decompression 02/17/2009 - "Video NeuroImage: symptomatic SUNCT syndrome cured after trigeminal neurovascular contact surgical decompression."
2.	Drug Therapy (Chemotherapy) 01/01/2011 - "SUNCT syndrome can be an extremely challenging headache type to manage and has been considered refractory to pharmacotherapy. " 09/01/2002 - "Short-lasting, unilateral, neuralgiform headache attacks with conjunctival injection, tearing, rhinorrhea (SUNCT syndrome) is a headache form generally refractory to drug therapy. "
3.	Deep Brain Stimulation 02/01/2009 - "The authors report on a case of SUNCT syndrome successfully treated with hypothalamic deep brain stimulation and discuss the current literature."
4.	Lasers (Laser) 01/01/2010 - "We report a 53-year-old woman with laser iridotomy (LI)-resistant angle-closure and conjunctival injection, which was thought to be the cause of ciliochoroidal effusion associated with short-lasting unilateral neuralgiform headache with conjunctival injection and tearing (SUNCT) syndrome. "
5.	Injections 10/01/2006 - "SUNCT syndrome was treated with a balloon microcompression procedure of the trigeminal ganglion, and the myofascial pain with injections and physical therapy. "