SUNCT Syndrome

A primary headache disorder that is characterized by frequent short-lasting, unilateral, neuralgiform pain attacks in the ocular area, with CONJUNCTIVA fluid-filling and tearing. SUNCT syndrome is usually resistant to treatment.

Also Known As:

Networked: 56 relevant articles (6 outcomes, 3 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Headache (Headaches)
2.	Headache Disorders (Headache Syndromes)
3.	Prescription Drug Overuse
4.	Prolactinoma (Prolactinomas)
5.	Pain (Aches)

Experts

1.	Goadsby, P J: 3 articles (10/2006 - 04/2002)
2.	Matharu, M S: 2 articles (11/2004 - 04/2002)
3.	Nappi, G: 2 articles (12/2003 - 11/2001)
4.	El Amrani, M: 2 articles (06/2002 - 01/2000)
5.	Benito-Leon, J: 2 articles (06/2002 - 04/2002)
6.	Berbel, A: 2 articles (06/2002 - 04/2002)
7.	Martinez-Salio, A: 2 articles (06/2002 - 04/2002)
8.	Porta-Etessam, J: 2 articles (06/2002 - 04/2002)
9.	Kawabata, Kazune: 1 article (03/2021)
10.	Sago, Teppei: 1 article (03/2021)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to SUNCT Syndrome:

1.	Lamotrigine (Lamictal)FDA LinkGeneric 09/01/2003 - "We concluded that lamotrigine is effective in treating SUNCT syndrome when used in high doses for a prolonged period of time." 09/01/2003 - "Influence of lamotrigine over the SUNCT syndrome: one patient follow-up for two years." 07/01/2003 - "SUNCT syndrome responsive to lamotrigine: documentation of the first Indian case." 09/01/2002 - "If the positive effect of lamotrigine in patients with SUNCT is confirmed in other cases, lamotrigine could become the first specific treatment for SUNCT syndrome." 09/01/2002 - "Both patients with SUNCT syndrome were successfully treated with lamotrigine. "
2.	Gabapentin (Neurontin)FDA LinkGeneric 12/01/2008 - "This study was designed to evaluate the efficacy of gabapentin (GBP) in the treatment of SUNCT syndrome on a relatively large sample of Persian patients. " 12/01/2008 - "Efficacy of gabapentin in the treatment of SUNCT syndrome." 06/01/2007 - "[Gabapentin in the treatment of SUNCT syndrome]." 06/01/2002 - "Gabapentin in the treatment of SUNCT syndrome." 04/01/2002 - "Gabapentin (neuronetin) in the treatment of SUNCT syndrome."
3.	Lidocaine (Xylocaine)FDA LinkGeneric 01/01/2010 - "Intravenous lidocaine should be considered in all patients with SUNCT syndrome. " 01/01/2010 - "Response to intravenous lidocaine in a patient with SUNCT syndrome." 11/01/2004 - "SUNCT syndrome responsive to intravenous lidocaine." 01/01/2010 - "We report a patient with SUNCT syndrome who showed a clear-cut and consistent response to intravenous lidocaine therapy, which proved superior to placebo in a single-blinded fashion. " 11/01/2008 - "Intravenous lidocaine is a novel treatment for chronic daily headache with medication overuse and SUNCT syndrome. "
4.	GlucocorticoidsIBA 10/01/2013 - "Complete remission of SUNCT syndrome by intravenous glucocorticoid treatment."
5.	Anesthetics (Anesthetic Agents)IBA 03/01/1995 - "SUNCT syndrome: trials of drugs and anesthetic blockades."
6.	Topiramate (Topamax)FDA LinkGeneric 04/01/2015 - "Based on the anamnesis, clinical examination and a magnetic resonance imaging scan, episodic SUNCT syndrome was diagnosed and pharmacological treatment with topiramate was started. " 06/28/2005 - "SUNCT syndrome: a possible bilateral case responding to topiramate." 12/01/2003 - "SUNCT syndrome successfully treated with topiramate: case reports." 04/23/2002 - "SUNCT syndrome: prolonged attacks, refractoriness and response to topiramate." 02/01/2008 - "[SUNCT syndrome (short-lasting unilateral neuralgiform headache with conjuntival injection and tearing): a rare case in a paediatric patient with favourable response to topiramate]."
7.	Oxcarbazepine (Trileptal)FDA LinkGeneric 09/01/2006 - "SUNCT syndrome with dramatic response to oxcarbazepine." 11/01/2009 - "SUNCT syndrome successfully treated with the combination of oxcarbazepine and gabapentin."
8.	Therapeutic UsesIBA 01/01/2002 - "However, caution is recommended when assessing any therapy in a disorder such as SUNCT syndrome, in which the rather chaotic and unpredictable temporal pattern makes the assessment of any drug/therapeutic effect per se a particularly difficult matter."
9.	Type A Botulinum Toxins (Botox)FDA Link 01/01/2016 - "Botulinum Toxin A for the Treatment of a Child with SUNCT Syndrome."
10.	Dopamine Agonists (Dopamine Agonist)IBA 03/01/2006 - "Short-lasting unilateral neuralgiform headache with conjunctival injection and tearing (SUNCT) syndrome may be associated with pituitary prolactinoma and may be induced by treatment of prolactinoma with dopamine agonists. "

Therapies and Procedures

1.	Surgical Decompression 02/17/2009 - "Video NeuroImage: symptomatic SUNCT syndrome cured after trigeminal neurovascular contact surgical decompression."
2.	Therapeutics 08/01/2010 - "So far, a clearly effective therapy for SUNCT syndrome has not been known. " 01/01/2006 - "The SUNCT syndrome is refractory to most commonly employed therapies. " 10/01/2004 - "For SUNCT syndrome, there is not such a drug which provides a practical approach to both diagnosis and therapy and its diagnosis depends on clinical features. " 01/01/1997 - "Consistent with previous reports, the present case of SUNCT syndrome was intractable to therapy. " 10/01/2012 - "This case represents the first case report of trigeminal autonomic cephalgia with SUNCT syndrome-like features illustrating possible problematic dental therapies. "
3.	Drug Therapy (Chemotherapy) 01/01/2011 - "SUNCT syndrome can be an extremely challenging headache type to manage and has been considered refractory to pharmacotherapy. " 09/01/2002 - "Short-lasting, unilateral, neuralgiform headache attacks with conjunctival injection, tearing, rhinorrhea (SUNCT syndrome) is a headache form generally refractory to drug therapy. "
4.	Intravenous Administration 03/01/2021 - "We present a case of SUNCT syndrome with successful pain relief by intravenous administration of ketamine, an N-methyl-D-aspartate receptor (NMDAR) antagonist. "
5.	Deep Brain Stimulation 02/01/2009 - "The authors report on a case of SUNCT syndrome successfully treated with hypothalamic deep brain stimulation and discuss the current literature."