STAT4 Transcription Factor

A signal transducer and activator of transcription that mediates cellular responses to INTERLEUKIN-12 in T-LYMPHOCYTES. Stat4 is an important signaling molecule for differentiation in TH1 CELLS.

Also Known As:

STAT4 Protein; STAT4A Transcription Factor; STAT4alpha Protein; STAT4b Transcription Factor; STAT4beta Protein; Signal Transducer and Activator of Transcription 4; Transcription Factor STAT4; Transcription Factor, STAT4; Transcription Factor, STAT4A; Transcription Factor, STAT4b

Networked: 84 relevant articles (0 outcomes, 17 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Kaplan, Mark H: 2 articles (01/2021 - 01/2005)
2.	Eloranta, Maija-Leena: 2 articles (01/2018 - 01/2013)
3.	Hagberg, Niklas: 2 articles (01/2018 - 01/2013)
4.	Rönnblom, Lars: 2 articles (01/2018 - 01/2013)
5.	Syvänen, Ann-Christine: 2 articles (01/2018 - 01/2013)
6.	Aslani, Saeed: 2 articles (06/2017 - 01/2017)
7.	Mahmoudi, Mahdi: 2 articles (06/2017 - 01/2017)
8.	Poursani, Shiva: 2 articles (06/2017 - 01/2017)
9.	Rezaei, Nima: 2 articles (06/2017 - 01/2017)
10.	Salmaninejad, Arash: 2 articles (06/2017 - 01/2017)

Related Diseases

1.	Systemic Lupus Erythematosus (Libman-Sacks Disease) 11/01/2010 - "Recent studies have identified signal transducer and activator of transcription 4 (STAT4) as a susceptibility gene for systemic lupus erythematosus (SLE) in different populations. " 10/01/2009 - "Recent studies have identified signal transducer and activator of transcription 4 (STAT4) as a susceptibility gene for systemic lupus erythematosus (SLE) in different populations. " 02/01/2021 - "Association of signal transducer and activator of transcription 4 (STAT4) gene rs7574865, rs10168266 polymorphisms with systemic lupus erythematosus (SLE) risk remains unclear. " 01/01/2018 - "Genetic variants in the transcription factor STAT4 are associated with increased susceptibility to systemic lupus erythematosus (SLE) and a more severe disease phenotype. " 02/01/2011 - "Polymorphisms in the transcription factor Stat4 gene have been implicated as risk factors for systemic lupus erythematosus. "
2.	Rheumatoid Arthritis 08/01/2014 - "The gene encoding signal transducer and activator of transcription 4 (STAT4) has been reported to be associated with rheumatoid arthritis (RA) in several populations. " 08/01/2014 - "Signal transducer and activator of transcription 4 (STAT4) G>T gene polymorphism in Egyptian cases with rheumatoid arthritis." 01/01/2014 - "An updated meta-analysis of the signal transducer and activator of transcription 4 (STAT4) rs7574865 G/T polymorphism and rheumatoid arthritis risk in an Asian population." 08/01/2011 - "Signal transducer and activator of transcription 4 gene polymorphisms associated with rheumatoid arthritis in Northwestern Chinese Han population." 12/01/2019 - "This study aims to investigate the association of polymorphism rs10181656 (C>G) of signal transducer and activator of transcription 4 (STAT4) gene with rheumatoid arthritis (RA) and systemic sclerosis (SSc) in the southwest of Iran as well as the probable relationship between the polymorphism with clinical features and disease activity parameters in both diseases. "
3.	Chronic Obstructive Pulmonary Disease (COPD) 07/01/2004 - "In conclusion, this study suggests that stable mild/moderate chronic obstructive pulmonary disease is associated with an active T-helper 1 cell/type-1 cytotoxic T-cell inflammatory process involving activation of signal transducer and activator of transcription 4 and interferon-gamma production." 07/01/2021 - " mRNA expressions of matrix metalloproteinase 2 (MMP-2),matrix metalloproteinase 12 (MMP-12),matrix metalloproteinase inhibitor 1 (TIMP-1),interleukin-6 (IL-6),and transforming growth factor-β1 (TGF-β1) were significantly reduced (P<0.01);whereas relative mRNA expressions of matrix metalloproteinase 9(MMP-9) and matrix metalloproteinase inhibitor 2 (TIMP-2) were increased significantly (P<0.01).The mRNA and protein expression levels of T-box transcription factor (T-bet),interleukin-12 (IL-12) and signal transducer and activator of transcription 4(STAT4) reduced to varying degrees (P<0.01,P<0.05).The mRNA of transcription factor GATA3 (binding protein-3),interleukin-4 (IL-4) and signal transducer and activator of transcription 6 (STAT6) in rat lung tissues and the protein expression levels of IL-4 and STAT6 were increased to varying degrees (P<0.01,P<0.05).In conclusion,anemoside B4 has a certain protective effect on COPD rats caused by cigarette smoke exposure and combined with LPS.The"
4.	Chronic Hepatitis B 01/01/2015 - "Recent studies demonstrated that single nucleotide polymorphisms (SNPs) rs2293152 in signal transducer and activator of transcription 3 (STAT3) and rs7574865 in signal transducer and activator of transcription 4 (STAT4) are associated with chronic hepatitis B (CHB)-related HCC in the Chinese population. " 01/01/2022 - "A variant in signal transducer and activator of transcription 4 (STAT4) was reported to correlate with the response of interferon-α (IFN-α) in a retrospective study in hepatitis B e antigen (HBeAg)-positive chronic hepatitis B virus (CHB) patients. "
5.	Hepatocellular Carcinoma (Hepatoma) 01/01/2016 - "Recent studies showed that signal transducer and activator of transcription 4 (STAT4) was downregulated in hepatocellular carcinoma (HCC) tissues. " 01/01/2022 - "We report the mechanism by which signal transducer and activator of transcription 4 (stat4) rs7574865 promotes the occurrence and progression of hepatocellular carcinoma (HCC). "

Related Drugs and Biologics

1.	Interleukins
2.	Interferon-gamma (Interferon, gamma)
3.	Cytokines
4.	Proteins (Proteins, Gene)
5.	Metalloproteases (Metalloproteinases)
6.	Nitric Oxide Synthase (NO Synthase)
7.	Interleukin-13
8.	HLA-DRB1 Chains (HLA DRB1)
9.	Non-Receptor Type 22 Protein Tyrosine Phosphatase
10.	Janus Kinase 2

Related Therapies and Procedures

1.	Immunomodulation
2.	Immunotherapy
3.	Drug Therapy (Chemotherapy)