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STAT1 Transcription Factor

Subscribe to New Research on STAT1 Transcription Factor

A signal transducer and activator of transcription that mediates cellular responses to INTERFERONS. Stat1 interacts with P53 TUMOR SUPPRESSOR PROTEIN and regulates expression of GENES involved in growth control and APOPTOSIS.

Also Known As:

Gamma-Activated Factor, 91 kDa; STAT-91 Protein; STAT-91 Transcription Factor; STAT1 Protein; STAT91 Transcription Factor; Signal Transducer and Activator of Transcription 1; Transcription Factor STAT91; Gamma Activated Factor, 91 kDa; STAT 91 Protein; STAT 91 Transcription Factor; Transcription Factor, STAT-91; Transcription Factor, STAT1; Transcription Factor, STAT91

Networked: 181 relevant articles (1 outcomes, 18 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins
- Proteins: 90489
- Peptides: 22950
  - Intracellular Signaling Peptides and Proteins: 22
    - Signal Transducing Adaptor Proteins
      - STAT Transcription Factors: 25
        STAT1 Transcription Factor: 181
        human STAT1 protein
        mouse Stat1 protein
        rat Stat1 protein
        Xenopus Stat1 protein
        zebrafish stat1 protein
      - Interferon-Stimulated Gene Factor 3: 6
        alpha Subunit Interferon-Stimulated Gene Factor 3
        STAT1 Transcription Factor: 181
        human STAT1 protein
        mouse Stat1 protein
        rat Stat1 protein
        Xenopus Stat1 protein
        zebrafish stat1 protein

Experts

1.	Lesinski, Gregory B: 5 articles (02/2010 - 01/2004)
2.	Fan, Xian-ming: 5 articles (10/2009 - 01/2003)
3.	Holland, Steven M: 4 articles (08/2014 - 09/2002)
4.	Wormley, Floyd L: 3 articles (12/2015 - 10/2012)
5.	Wozniak, Karen L: 3 articles (12/2015 - 10/2012)
6.	Hole, Camaron R: 3 articles (12/2015 - 10/2012)
7.	Müller, Mathias: 3 articles (08/2013 - 09/2010)
8.	Behrmann, Iris: 3 articles (07/2012 - 02/2004)
9.	Zimmerer, Jason M: 3 articles (02/2010 - 09/2007)
10.	Carson, William E: 3 articles (02/2010 - 09/2007)

Related Diseases

1.	Carcinoma (Carcinomatosis) 09/01/2010 - "The objective of this study was investigate signal transducer and activator of transcription 1 and matrix metalloproteinase 3 genetic expression and clinical significance on urothelial carcinoma after renal transplantation. " 01/01/2014 - "The increase of the expression of type I interferon (IFN) and its classical effective molecules and the phosphorylation of signal transducers and activators of transcription (STAT1) protein indicated that miR-122 might enhance type I interferon in cervical carcinoma cells, which explained the significant reduction of HPV16 E7 and E6*I mRNA expression. " 02/01/2002 - "Interferon-alpha resistance in renal carcinoma cells is associated with defective induction of signal transducer and activator of transcription 1 which can be restored by a supernatant of phorbol 12-myristate 13-acetate stimulated peripheral blood mononuclear cells."
2.	Neoplasms (Cancer) 08/01/2015 - "The current study was designed to explore the role of signal transducer and activator of transcription 1 (Stat1) during tumor promotion using the mouse skin multistage carcinogenesis model. " 04/01/2011 - "This study aimed to investigate the effect of radiation on the levels of signal transducer and activator of transcription 1 (STAT1) in mammospheres of cancer-initiating cells and monolayer cultures of MCF-7 cells. " 10/20/2015 - "In this context, the selectivity of inhibitors against the STAT1 transcription factor is crucial as STAT3 and STAT1 play opposite roles in the apoptosis of tumor cells and polarization of the immune response. " 04/28/2015 - "The signal transducer and activator of transcription 1 (Stat1) functions as a tumor suppressor via immune regulatory and cell-autonomous pathways. " 01/01/2014 - "Loss of STAT1 (Signal Transducer and Activator of Transcription-1) has been implicated in the pathobiology of a number of cancer types. "
3.	Infection 01/01/2004 - "This study was designed to determine the roles of STAT1 protein in defense against mycobacterial infection. " 12/01/2015 - "neoformans infection is associated with the generation of a T helper 1 (Th1)-type immune response and signal transducer and activator of transcription 1 (STAT1)-mediated classical (M1) macrophage activation. " 11/01/2015 - "muridarum infection significantly increased STAT1 gene expression and protein activation in WT OE cells; however, TLR3-deficient OE cells showed diminished STAT1 protein activation and gene expression. " 06/01/2015 - "Signal transducer and activator of transcription 1 (STAT-1) plays a critical role in control of Trypanosoma cruzi infection." 02/01/2015 - "In contrast, RSV-infected RAW 264.7 cells increased expression of the STAT1 protein occurred at between 6 and 12h post-infection, which coincided with the appearance of P-STAT1. "
4.	Inflammation 09/01/2009 - "Ongoing microarray studies indicate that suppressive ODN interfere with the phosphorylation of signal transducer and activator of transcription 1 (STAT1) and STAT4, thereby blocking the inflammation mediated by STAT-associated signaling cascades. " 09/01/2015 - "However, C-BF significantly induced the phosphorylation of signal transducer and activator of transcription 1 (STAT-1) to enhance the phagocytosis of macrophages when inflammation was suppressed. " 01/01/2015 - "However, deletion of the PDGFRβ-activated transcription factor STAT1 in VSMCs alleviates inflammation of the arterial wall and reduces plaque burden. " 01/16/2014 - "Repeat inflammation induced IL-6-mediated T helper 1 (Th1) cell effector commitment and the emergence of STAT1 (signal transducer and activator of transcription-1) activity within the peritoneal membrane. " 11/26/2010 - "The molecular pathways regulating signal transducer and activator of transcription 1 (STAT1) levels in states of inflammation are incompletely understood. "
5.	Reperfusion Injury 05/01/2010 - "This study focuses on Janus kinase-2 (JAK2), which functions upstream of signal transducer and activator of transcription 1 (STAT1) in JAK/STAT, and its role in the mechanism of liver ischemia/reperfusion injury (IRI). " 02/01/2012 - "Previous studies have shown that the transcription factor signal transducer and activator of transcription 1 (STAT1) activation is increased in primary cardiac myocytes exposed to simulated ischaemia/reperfusion injury. " 11/01/2008 - "In an in vitro model of renal ischemia/reperfusion injury (IRI), we investigated the role of Jak2 kinase inhibition on signal transducer and activator of transcription 1 (Stat1) and Stat3 activations as well as apoptosis of human proximal tubular epithelial cells (HKCs) induced by adenosine triphosphate (ATP) depletion/recovery. "

Related Drugs and Biologics

1.	Messenger RNA (mRNA)
2.	Interferon Type I
3.	Transcription Factors (Transcription Factor)
4.	STAT1 Transcription Factor
5.	Interferons
6.	Interferon-gamma (Interferon, gamma)
7.	Caspase 8 (Caspase-8)
8.	Protein-Tyrosine Kinases (Tyrosine Kinase)
9.	DNA (Deoxyribonucleic Acid)
10.	interferon gamma receptor

Related Therapies and Procedures

1.	Kidney Transplantation
2.	Drug Therapy (Chemotherapy)