STAT Transcription Factors

A family of transcription factors containing SH2 DOMAINS that are involved in CYTOKINE-mediated SIGNAL TRANSDUCTION. STAT transcription factors are recruited to the cytoplasmic region of CELL SURFACE RECEPTORS and are activated via PHOSPHORYLATION. Once activated they dimerize and translocate into the CELL NUCLEUS where they influence GENE expression. They play a role in regulating CELL GROWTH PROCESSES and CELL DIFFERENTIATION. STAT transcription factors are inhibited by SUPPRESSOR OF CYTOKINE SIGNALING PROTEINS and PROTEIN INHIBITORS OF ACTIVATED STAT.

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Networked: 45 relevant articles (1 outcomes, 2 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Dötsch, Volker: 1 article (01/2022)
2.	Fester, Niclas: 1 article (01/2022)
3.	Frombach, Ann-Sophie: 1 article (01/2022)
4.	Goldmann, Jakob: 1 article (01/2022)
5.	Gutfreund, Niklas: 1 article (01/2022)
6.	Müller-Kuller, Uta: 1 article (01/2022)
7.	Rajalingam, Krishnaraj: 1 article (01/2022)
8.	Riegel, Kristina: 1 article (01/2022)
9.	Schleiff, Enrico: 1 article (01/2022)
10.	Simm, Stefan: 1 article (01/2022)

Related Diseases

1.	Reperfusion Injury 05/01/2004 - "Heat shock proteins (HSPs) have been shown to be protective against ischemia-reperfusion injury, and STAT (Signal Transducers and Activators of Transcription) proteins are pivotal determinants of the cellular response to reperfusion injury. "
2.	Glioma (Gliomas) 08/01/2002 - "The purpose of this study was to compare the effects of neurotrophic cytokines on the JAK/STAT transcription factors and the immediate early gene, c-fos, in C6 glioma cells and in primary astrocyte cultures. "
3.	Acute-Phase Reaction 01/01/2009 - "The present study aimed at determining whether chronic dietary restriction affects haptoglobin blood levels through changing levels and/or activities of IL-6-related transcription factors STAT and C/EBP in the liver as is the case during the acute phase response. "
4.	Neoplasms (Cancer) 01/01/2013 - "This represents a new type of intercellular signaling and a new way of activating the STAT transcription factors that could be of interest for the design of cancer treatments. " 04/01/2012 - "This review details the cell signaling pathways involving STAT transcription factors as well as the corresponding compounds from nature able to interfere with this regulatory system in human cancer." 03/01/2008 - "Constitutive JAK activation leads to persistent activation of STAT transcription factors, and several cancers exhibit constitutive STAT activation, in the absence of JAK or STAT activating mutations. " 05/02/2006 - "Aberrant activation of STAT transcription factors has been implicated in a variety of cancers. " 01/01/2022 - "Signal transducers and activators of transcription (STAT) transcription factors, a family of genes encoding transcription factors, have been linked to the development of numerous types of tumors. "
5.	Carcinogenesis 01/20/2012 - "STAT transcription factors play critical roles in mammary gland tumorigenesis, but the precise role of STAT1 remains unclear. " 01/01/2009 - "Stat transcription factors have been implicated in tumorigenesis in mice and men. " 01/01/2001 - "Stat transcription factors in mammary gland development and tumorigenesis." 03/01/2007 - "Stat transcription factors are activated by cytokines and can activate pathways important in oncogenesis. " 05/01/1998 - "While signal transducers and activators of transcription (STATs) were originally discovered as intracellular effectors of normal signaling by cytokines, increasing evidence also points to a role for STAT transcription factors in oncogenesis. "

Related Drugs and Biologics

1.	Heat-Shock Proteins (Heat-Shock Protein)
2.	Cytokines
3.	Haptoglobins
4.	Transcription Factor AP-1 (Transcription Factor AP 1)
5.	NF-kappa B (NF-kB)
6.	Transcription Factors (Transcription Factor)
7.	Proteins (Proteins, Gene)
8.	Janus Kinases
9.	Interferon Regulatory Factors
10.	Intercellular Signaling Peptides and Proteins (Growth Factors)

Related Therapies and Procedures

1.	Diet Therapy (Therapy, Diet)
2.	Immunotherapy
3.	Drug Therapy (Chemotherapy)