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Proto-Oncogene Proteins c-ets

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A family of transcription factors that share a unique DNA-binding domain. The name derives from viral oncogene-derived protein oncogene protein v-ets of the AVIAN ERYTHROBLASTOSIS VIRUS.

Also Known As:

Proto-Oncogene Protein ets; c-ets Protein; ets Transcription Factors; Proto Oncogene Protein ets; Proto Oncogene Proteins c ets; Proto-Oncogene Proteins, c-ets; Proto-Oncogene Proteins, ets; Transcription Factors, ets; c ets Protein; c ets Proto Oncogene Proteins; c-ets, Proto-Oncogene Proteins; ets Proto Oncogene Proteins; c-ets Proto-Oncogene Proteins; ets Proto-Oncogene Proteins

Networked: 96 relevant articles (0 outcomes, 5 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins
- Proteins: 90489

Experts

1.	Chinnaiyan, Arul M: 8 articles (10/2013 - 10/2005)
2.	Tomlins, Scott A: 7 articles (02/2015 - 10/2005)
3.	Teixeira, Manuel R: 5 articles (03/2015 - 01/2012)
4.	Lothe, Ragnhild A: 5 articles (03/2015 - 01/2012)
5.	Mehra, Rohit: 5 articles (08/2013 - 10/2005)
6.	Paulo, Paula: 4 articles (03/2015 - 01/2012)
7.	Barros-Silva, João D: 4 articles (03/2015 - 01/2012)
8.	Henrique, Rui: 4 articles (07/2013 - 01/2012)
9.	Jerónimo, Carmen: 4 articles (07/2013 - 01/2012)
10.	Rubin, Mark A: 4 articles (02/2013 - 10/2005)

Related Diseases

1.	Neoplasms (Cancer) 05/01/2013 - "Lastly, population differences in the frequency of oncogenic erythroblast transformation-specific family of transcription factors (ETS)-related gene rearrangements were evaluated in three studies that showed that these alterations manifest themselves most commonly in tumors from men of European ancestry, but are significantly less frequent in men of African ancestry, whereas least common in men of Asian ancestry. " 01/01/2009 - "Ets transcription factors have been widely implicated in the control of tumorigenesis, with most studies suggesting tumor-promoting roles. " 07/01/2014 - "Based on an initial observation that CIC-DUX4-positive tumors show nuclear immunoreactivity for WT1 and ETS transcription factors, FLI1 and ERG, we performed a detailed immunohistochemical and molecular analysis including these markers, to further investigate the relationship between CIC-DUX4 tumors and ES. " 01/01/2014 - "We have previously shown that over-expression of "oncogenic" ETS transcription factors, which occurs in about one-half of prostate tumors due to chromosome rearrangement, can bypass the need for RAS/ERK signaling in the activation of a cell migration gene expression program. " 03/29/2013 - "Myeloid ELF1-like factor (MEF/ELF4), a member of the ETS transcription factors, can function as an oncogene in murine cancer models and is overexpressed in various human cancers. "
2.	Sarcoma (Soft Tissue Sarcoma) 08/01/2014 - "Translocations involving ETS-transcription factors, most commonly leading to the EWSR1-FLI1 fusion protein, are the hallmark of Ewing sarcoma. " 07/01/2014 - "Expression profiling validated by q-PCR revealed a distinct gene signature associated with CIC-DUX4 fusion, with upregulation of ETS transcription factors (ETV4, ETV1, and ETV5) and WT1, among top overexpressed genes compared to ES, other sarcomas and normal tissue. " 04/01/2006 - "In this study, STAT3 activation was assessed in the Ewing sarcoma family of tumours (ESFT), which is characterized by fusion of the EWS gene with one of several Ets transcription factors, most commonly EWS-FLI1. " 10/01/1999 - "Ewing sarcoma and related peripheral primitive neuroectodermal tumours share recurrent translocations that fuse the gene EWSR1 (formerly EWS) from 22q-12 to FLI1 and genes encoding other ETS transcription factors (which bind DNA through the conserved ETS domain). " 01/09/2003 - "The chromosomal translocation specifically linked to the Ewing sarcoma family results in the generation of fusion proteins comprising the amino terminal portion of EWS and the DNA-binding domain of ets transcription factors. "
3.	B-Cell Chronic Lymphocytic Leukemia (Chronic Lymphocytic Leukemia) 12/01/2011 - "In the present study, we explored the global gene expression profiles of the glial cell line-derived neurotrophic factor (GDNF)-regulated transcription factors Ets (E-twenty-six) variant gene 5 (Etv5); B-cell chronic lymphocytic leukemia (CLL)/lymphoma 6, member B (Bcl6b); and POU domain, class-3 transcription factor 1 (Pou3f1). "
4.	Skin Neoplasms (Skin Cancer) 11/03/2015 - "The results from this study show occurrence of frequent somatic non-coding mutations adjacent to a pre-existing binding site for Ets transcription factors within the directional promoter of DPH3 and OXNAD1 genes in three major skin cancers. "
5.	Lymphoma (Lymphomas) 12/01/2011 - "In the present study, we explored the global gene expression profiles of the glial cell line-derived neurotrophic factor (GDNF)-regulated transcription factors Ets (E-twenty-six) variant gene 5 (Etv5); B-cell chronic lymphocytic leukemia (CLL)/lymphoma 6, member B (Bcl6b); and POU domain, class-3 transcription factor 1 (Pou3f1). "

Related Drugs and Biologics

1.	Glial Cell Line-Derived Neurotrophic Factor (GDNF)
2.	Transcription Factors (Transcription Factor)
3.	EWS-FLI1 fusion protein
4.	Proteins (Proteins, Gene)
5.	DNA (Deoxyribonucleic Acid)
6.	Serine Proteases (Serine Protease)
7.	Matrix Metalloproteinases
8.	Toll-Like Receptors (Toll-Like Receptor)
9.	Integrin alpha3
10.	RNA-Binding Protein EWS