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Protoporphyrinogen Oxidase (Protox)

A membrane-bound flavoenzyme that catalyzes the oxygen-dependent aromatization of protoporphyrinogen IX (Protogen) to protoporphyrin IX (Proto IX). It is the last enzyme of the common branch of the HEME and CHLOROPHYLL pathways in plants, and is the molecular target of diphenyl ether-type herbicides. VARIEGATE PORPHYRIA is an autosomal dominant disorder associated with deficiency of protoporphyrinogen oxidase.
Also Known As:
Protox; Oxidase, Protoporphyrinogen; Protoporphyrinogen Dehydrogenase; Protoporphyrinogen IX Oxidase; Protoporphyrinogenase; Dehydrogenase, Protoporphyrinogen; Oxidase, Protoporphyrinogen IX
Networked: 120 relevant articles (0 outcomes, 5 trials/studies)

Bio-Agent Context: Research Results

Experts

1. Frank, J: 5 articles (02/2012 - 01/2001)
2. Deybach, Jean-Charles: 4 articles (11/2019 - 02/2002)
3. Frank, Jorge: 4 articles (03/2015 - 07/2006)
4. Poblete-Gutiérrez, Pamela: 4 articles (03/2015 - 07/2006)
5. Gouya, Laurent: 3 articles (09/2021 - 02/2004)
6. Puy, Hervé: 3 articles (11/2019 - 02/2002)
7. Ichimura, Ryohei: 3 articles (01/2017 - 01/2016)
8. Inoue, Kaoru: 3 articles (01/2017 - 01/2016)
9. Kodama, Yukio: 3 articles (01/2017 - 01/2016)
10. Kuwata, Kazunori: 3 articles (01/2017 - 01/2016)

Related Diseases

1. Variegate Porphyria (Protoporphyrinogen Oxidase Deficiency)
2. Acute Intermittent Porphyria (Porphyria, Acute)
3. Pancreatic Neoplasms (Pancreatic Cancer)
4. Body Weight (Weight, Body)
5. Porphyrias (Porphyria)

Related Drugs and Biologics

1. Enzymes
2. Heme (Haem)
3. Hydroxymethylbilane Synthase (Porphobilinogen Deaminase)
4. Herbicides
5. Coproporphyrinogen Oxidase (Coproporphyrinogen III Oxidases)
6. Porphyrins
7. protoporphyrin IX
8. Ferrochelatase (Heme Synthetase)
9. Proteins (Proteins, Gene)
10. Uroporphyrinogen Decarboxylase (Uroporphyrinogen III Decarboxylase)

Related Therapies and Procedures

1. Photochemotherapy (Photodynamic Therapy)
2. Lasers (Laser)