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Qa-SNARE Proteins (Syntaxin)

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A subfamily of Q-SNARE PROTEINS which occupy the same position as syntaxin 1A in the SNARE complex and which also are most similar to syntaxin 1A in their AMINO ACID SEQUENCE. This subfamily is also known as the syntaxins, although a few so called syntaxins are Qc-SNARES.

Also Known As:

Syntaxin; Qa-SNAREs; Syntaxin 10; Syntaxin 10 Protein; Syntaxin 11; Syntaxin 11 Protein; Syntaxin 13; Syntaxin 13 Protein; Syntaxin 17; Syntaxin 17 Protein; Syntaxin 18; Syntaxin 18 Protein; Syntaxin 1A Homologs; Syntaxin 3; Syntaxin 3 Protein; Syntaxin 3A; Syntaxin 3A Protein; Syntaxin 3B; Syntaxin 3B Protein; Syntaxin 3C; Syntaxin 3C Protein; Syntaxin 3D; Syntaxin 3D Protein; Syntaxin 4; Syntaxin 4 Protein; Syntaxin 5; Syntaxin 5 Protein; Syntaxin 6; Syntaxin 6 Protein; Syntaxin 7; Syntaxin 7 Protein; Syntaxin 8; Syntaxin 8 Protein; Syntaxin Protein; Syntaxin Proteins; Syntaxins; 11 Protein, Syntaxin; Protein, Syntaxin; Protein, Syntaxin 11; Proteins, Syntaxin; Qa SNARE Proteins; Qa SNAREs

Networked: 125 relevant articles (0 outcomes, 11 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins
- Proteins: 90489
  - Membrane Proteins: 5300
    - Membrane Fusion Proteins: 1
      - SNARE Proteins: 165
        Q-SNARE Proteins
        Qa-SNARE Proteins: 125
        Syntaxin 1: 46
        Arabidopsis ATPEP12 protein
        Arabidopsis KNOLLE protein
        Arabidopsis PEN1 protein
        Arabidopsis SYP124 protein
        Arabidopsis SYP31 protein
        Arabidopsis SYP41 protein
        Arabidopsis SYP61 protein
        Arabidopsis Vam3 protein
        C elegans Syn-1 protein
        human STX11 protein
        human STX12 protein
        human STX17 protein
        mouse Stx11 protein
        mouse syntaxin 12
        Nicotiana tabacum NtSyr1 protein
        rat syntaxin 12
        S cerevisiae PEP12 protein
        S cerevisiae Sed5 protein
        S cerevisiae SSO1 protein
        S cerevisiae SSO2 protein
        S cerevisiae TLG2 protein
        S cerevisiae UFE1 protein
        S cerevisiae VAM3 protein
        S pombe Psy1 protein
        Syntaxin 16
    - Vesicular Transport Proteins
      - SNARE Proteins: 165
        Q-SNARE Proteins
        Qa-SNARE Proteins: 125
        Syntaxin 1: 46
        Arabidopsis ATPEP12 protein
        Arabidopsis KNOLLE protein
        Arabidopsis PEN1 protein
        Arabidopsis SYP124 protein
        Arabidopsis SYP31 protein
        Arabidopsis SYP41 protein
        Arabidopsis SYP61 protein
        Arabidopsis Vam3 protein
        C elegans Syn-1 protein
        human STX11 protein
        human STX12 protein
        human STX17 protein
        mouse Stx11 protein
        mouse syntaxin 12
        Nicotiana tabacum NtSyr1 protein
        rat syntaxin 12
        S cerevisiae PEP12 protein
        S cerevisiae Sed5 protein
        S cerevisiae SSO1 protein
        S cerevisiae SSO2 protein
        S cerevisiae TLG2 protein
        S cerevisiae UFE1 protein
        S cerevisiae VAM3 protein
        S pombe Psy1 protein
        Syntaxin 16

Experts

1.	Honer, William G: 5 articles (09/2015 - 07/2004)
2.	Barr, Alasdair M: 3 articles (09/2015 - 07/2004)
3.	Honer, W G: 3 articles (01/2012 - 08/2000)
4.	Dwork, Andrew J: 2 articles (09/2015 - 04/2010)
5.	Beasley, Clare L: 2 articles (09/2015 - 04/2010)
6.	Mann, J John: 2 articles (09/2015 - 04/2010)
7.	Oh, Eunjin: 2 articles (05/2014 - 03/2010)
8.	Thurmond, Debbie C: 2 articles (05/2014 - 03/2010)
9.	Sundström, Elisabeth: 2 articles (01/2014 - 01/2014)
10.	Andersson, Leif: 2 articles (01/2014 - 01/2014)

Related Diseases

1.	Schizophrenia (Dementia Praecox) 04/01/2010 - "In schizophrenia samples, compared with controls, SNAP-25 was 32% lower (P=0.015) and syntaxin was 26% lower (P=0.006) in the VMC. " 02/01/2010 - "On the basis of previous studies reporting reductions in the levels and activity of CK2 (also know as casein kinase 2 or II) in the brain of subjects with schizophrenia, we hypothesized that CK2-mediated phosphorylation of the presynaptic protein syntaxin 1 (Stx 1) is deficient in schizophrenia. " 07/01/2004 - "Both microarray and candidate molecule studies have demonstrated that protein and mRNA expression of syntaxin and other genes involved in synaptic function are altered in the cerebral cortex of patients with schizophrenia. " 07/01/2004 - "CDCrel-1 modulates dopamine neurotransmission, binds to the SNARE protein syntaxin and maps onto a region of chromosome 22q11 deleted in velo-cardio-facial and DiGeorge syndromes, which are associated with increased prevalence of schizophrenia. " 05/01/1997 - "Controlled for age and post mortem interval, syntaxin immunoreactivity was significantly elevated in schizophrenia (P=0.004), and neural cell adhesion molecule immunoreactivity was also elevated (P=0.05). "
2.	Infection 06/01/2005 - "Genetic studies identified a highly conserved L2 domain, DKILK, comprising residues 40 to 44 that mediated BPV1 trafficking through the ER during infection via an interaction with the tSNARE syntaxin 18. " 01/19/2012 - "During infection there is noncanonical pairing of the SNARE protein Sec22b on ER-derived vesicles with plasma membrane (PM)-localized syntaxin proteins on the vacuole. " 09/01/2011 - "In contrast, syntaxin in innate immunity does not need upregulation of expression but instead requires pathogen-induced and endocytosis-dependent retargeting to the infection site. " 07/01/2007 - "These results support the dependence of syntaxin 18 during BPV1 infection and the ability to interfere with infection by targeting the L2-syntaxin 18 interaction and further define the infectious route of BPV1 mediated by the L2 protein." 07/01/2007 - "In this paper, we describe that syntaxin 18 colocalizes with infectious bovine papillomavirus type 1 (BPV1) pseudovirions during infection but does not colocalize with the noninfectious BPV1 pseudovirions made with an L2 mutant at residues 41 to 44. "
3.	Neuroblastoma 06/01/2009 - "Identification of the neuroblastoma-amplified gene product as a component of the syntaxin 18 complex implicated in Golgi-to-endoplasmic reticulum retrograde transport." 03/01/1999 - "These genes are also expressed in human peripheral blood lymphocytes and SH-SY5Y neuroblastoma cells, which, unlike neutrophils, also expressed syntaxin 10. " 06/01/2009 - "In the present study, we showed that a peripheral membrane protein encoded by the neuroblastoma-amplified gene (NAG) is a subunit of the syntaxin 18 complex. " 08/01/2001 - "The demonstration, using BoNTs, of the crucial role of SNAP-25, VAMP and syntaxin in SH-SY5Y cells suggests the use of this neuroblastoma as a model in the study of these proteins in neurotransmitter release." 04/01/1997 - "Western blot analysis showed that the human neuroblastoma SH-SY5Y expresses the proteins synaptotagmin l, synaptobrevin, synapsin-l, rab3a, syntaxin, SNAP-25, NSF, alpha-SNAP, and munc-18, which have been implicated in the movement, docking, and fusion of vesicles during exocytosis from other neuroendocrine cells. "
4.	Hemophagocytic Lymphohistiocytosis (Hemophagocytic Syndrome) 09/20/2012 - "In the present study, we tested these conclusions using platelets from syntaxin-knockout mouse strains and from a Familial Hemophagocytic Lymphohistiocytosis type 4 (FHL4) patient. " 03/01/2016 - "We report the first Far Eastern case of a Korean child with familial hemophagocytic lymphohistiocytosis (HLH) caused by a novel syntaxin 11 (STX11) mutation. " 03/01/2016 - "A Novel Syntaxin 11 Gene (STX11) Mutation c.650T>C, p.Leu217Pro, in a Korean Child With Familial Hemophagocytic Lymphohistiocytosis." 01/01/2014 - "Natural killer (NK) cell secretory lysosome exocytosis and cytotoxicity are impaired in familial hemophagocytic lymphohistiocytosis type 4 (FHL-4), a disorder caused by mutations in the gene encoding the SNARE protein syntaxin 11. " 11/19/2013 - "Mutations in either syntaxin 11 (Stx11) or Munc18-2 abolish cytotoxic T lymphocytes (CTL) and natural killer cell (NK) cytotoxicity, and give rise to familial hemophagocytic lymphohistiocytosis (FHL4 or FHL5, respectively). "
5.	Dementia (Dementias) 01/01/2012 - "After accounting for AD pathology and infarcts, greater amounts of vesicle-associated membrane protein, complexins I and II and the SNAP-25/syntaxin interaction were associated with lower odds of dementia (odds ratio = 0.36-0.68, P < 0.001 to P = 0.03) and better cognitive function (P < 0.001 to P = 0.03). " 01/01/2012 - "Greater cortical atrophy, a putative dementia biomarker, was not associated with AD pathology, but was associated with lower complexin-II (P = 0.01) and lower SNAP-25/syntaxin interaction (P < 0.001). " 01/01/2009 - "In comparison with the control group and the dementia groups without LBs, the LBV group had significantly lower levels of syntaxin and SNAP-25 (23%) in the neocortex, and depletion of MAP2 (64%), SNAP-25 (34%), and alpha-synuclein (44%) proteins in the medial temporal lobes. " 08/01/2000 - "Contrary to previous studies, we report increases in the levels of synaptophysin, syntaxin, and SNAP-25 at stage 3 and of alpha-synuclein and MAP2 at stage 4. Minimal and mild clinical grades of dementia were associated with either unchanged or elevated levels of synaptic proteins in the neocortex. "

Related Drugs and Biologics

1.	Proteins (Proteins, Gene)
2.	Synaptophysin
3.	Synaptotagmins (Synaptotagmin)
4.	SNARE Proteins (SNAREs)
5.	Neurotransmitter Agents (Neurotransmitter)
6.	Messenger RNA (mRNA)
7.	alpha-Synuclein
8.	Vesicle-Associated Membrane Protein 2 (VAMP2)
9.	Membrane Proteins (Integral Membrane Proteins)
10.	Immunoglobulin E (IgE)

Related Therapies and Procedures

1.	Transplants (Transplant)