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Cyclin-Dependent Kinase Inhibitor p21

Subscribe to New Research on Cyclin-Dependent Kinase Inhibitor p21

A cyclin-dependent kinase inhibitor that mediates TUMOR SUPPRESSOR PROTEIN P53-dependent CELL CYCLE arrest. p21 interacts with a range of CYCLIN-DEPENDENT KINASES and associates with PROLIFERATING CELL NUCLEAR ANTIGEN and CASPASE 3.

Also Known As:

CDK2-Associated Protein 20 kDa; CDKN1 Protein; CDKN1A Protein; Cdk-Interacting Protein 1; Cdk2 Inhibitor Protein; Cell Cycle Regulator p21; Cyclin Kinase Inhibitor p21; Cyclin-Dependent Kinase Inhibitor 1A Protein; Senescent Cell-Derived Inhibitor Protein 1; p21 Cell Cycle Regulator; p21 Cyclin Kinase Inhibitor; CDK2 Associated Protein 20 kDa; Cdk Interacting Protein 1; Cyclin Dependent Kinase Inhibitor 1A Protein; Cyclin Dependent Kinase Inhibitor p21; Senescent Cell Derived Inhibitor Protein 1

Networked: 194 relevant articles (3 outcomes, 13 trials/studies)

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Bio-Agent Context: Research Results

Experts

1.	Augenlicht, Leonard H: 4 articles (10/2005 - 08/2002)
2.	Weiss, Robert H: 3 articles (04/2011 - 03/2004)
3.	Safe, Stephen: 3 articles (07/2009 - 09/2002)
4.	Velcich, Anna: 3 articles (04/2005 - 08/2002)
5.	O'Reilly, M A: 3 articles (10/2001 - 04/2001)
6.	Kovacevic, Zaklina: 2 articles (01/2013 - 10/2011)
7.	Lovejoy, David B: 2 articles (01/2013 - 10/2011)
8.	Richardson, Des R: 2 articles (01/2013 - 10/2011)
9.	Zuckerbraun, Brian S: 2 articles (06/2012 - 01/2010)
10.	Song, Libing: 2 articles (05/2011 - 11/2010)

Related Diseases

1.	Neoplasms (Cancer) 04/01/2005 - "In the Apc1638(+/-) mouse model of intestinal tumorigenesis, targeted inactivation of the cyclin-dependent kinase inhibitor p21(WAF1/cip1) is highly effective in enhancing Apc-initiated tumor formation in the intestine. " 08/01/2010 - "In this study, we investigated the importance of the cyclin-dependent kinase inhibitor p21/Waf-1, on viral replication and tumor growth. " 02/08/2010 - "In this study, we show that in otherwise diploid human cells, chromosome missegregation causes a cell cycle delay with nuclear accumulation of the tumor suppressor p53 and the cyclin kinase inhibitor p21. " 01/01/2015 - "Mechanistically, we show that IL-1β activates the tumor suppressor p53 through an oxidative stress-dependent mechanism resulting in p53-mediated induction of the cyclin-dependent kinase inhibitor p21 and the proapoptotic Bcl-2 (B-cell lymphoma-2) family members Puma (p53-upregulated modulator of apoptosis) and Noxa. " 09/01/2013 - "The cyclin-dependent kinase inhibitor p21 is an important transcriptional target of several tumor suppressors, which promotes cell cycle arrest in response to many stimuli. "
2.	Ovarian Neoplasms (Ovarian Cancer) 11/01/2011 - "In this study, we showed that LPA upregulated expression of the cyclin-dependent kinase inhibitor p21(Waf1) in TGFβ-sensitive breast and ovarian cancer cells, but not in TGFβ-resistant ones. " 10/01/2004 - "Persistence of ARHI expression in epithelial ovarian cancers correlated with prolonged disease free survival and expression of the cyclin dependent kinase inhibitor p21(WAF1/CIP1)." 06/10/1998 - "We have demonstrated over-expression of the cyclin-dependent kinase inhibitor p21 in various ovarian-cancer cell lines as well as in ovarian-tumor biopsies. " 06/01/2007 - "Heterologous expression of ERbeta1, but not of the exon-deleted ERbeta variants resulted in notably slower cell growth of SK-OV-3 ovarian cancer cells, an effect accompanied by more than tenfold increase of cyclin-dependent kinase inhibitor p21(WAF1) transcript levels and a significant reduction of cyclin A2 mRNA levels. "
3.	Breast Neoplasms (Breast Cancer) 06/01/2013 - "Cell cycle regulator p21(CIP1) has controversial biological effects in breast cancer since in spite of its role as cell cycle inhibitor and promoter of cellular senescence, it also induces cell proliferation and chemoteraphy resistance. " 05/01/2012 - "Activation of AMPK by these EGCG analogs resulted in inhibition of cell proliferation, up-regulation of the cyclin-dependent kinase inhibitor p21, down-regulation of mTOR pathway, and suppression of stem cell population in human breast cancer cells. " 11/01/2010 - "Moreover, we demonstrated that the anti-proliferative effect of silencing Sam68 on breast cancer cells was associated with up-regulation of cyclin-dependent kinase inhibitor p21(Cip1) and p27(Kip1), enhanced transactivation of FOXO factors, and attenuation of Akt/GSK-3β signalling. " 11/01/2007 - "Expression of SphK2, which is enriched in the nucleus of MCF7 human breast cancer cells, increased expression of the cyclin-dependent kinase inhibitor p21 but had no effect on p53 or its phosphorylation. " 01/01/1997 - "Antiprogestin inhibition of cell cycle progression in T-47D breast cancer cells is accompanied by induction of the cyclin-dependent kinase inhibitor p21."
4.	Hyperoxia 10/01/2002 - "Our recent observation that hyperoxia inhibits proliferation through induction of the cyclin-dependent kinase inhibitor p21(Cip1/WAF1/Sdi1), which also facilitates DNA repair, suggested that p21 may participate in remodeling. " 04/01/2001 - "Previous studies have shown that hyperoxia inhibits proliferation and increases the expression of the tumor suppressor p53 and its downstream target, the cyclin-dependent kinase inhibitor p21(CIP1/WAF1), which inhibits proliferation in the G1 phase of the cell cycle. " 05/01/2005 - "Exposure to chronic oxidative stress during elevated oxygen (hyperoxia) damages DNA and inhibits cell proliferation in G(1) through induction of the cyclin-dependent kinase inhibitor p21. " 06/01/2001 - "Although hyperoxia induces the tumor suppressor p53 and its downstream target, the cyclin-dependent kinase inhibitor p21(Cip1/WAF1/Sdi1) (p21), their role in pulmonary injury remains unknown. " 05/01/2011 - "Given recent data on altered histone deacetylase (HDAC) activity in lungs of humans and animal models with airspace enlargement/emphysema, we hypothesized that alveolar hypoplasia from hyperoxia exposure in neonatal mice is a consequence of cell cycle arrest and reduced HDAC activity and up-regulation of the cyclin-dependent kinase inhibitor, p21. "
5.	Hepatocellular Carcinoma (Hepatoma) 06/01/2007 - "Hepatocyte senescence in end-stage chronic liver disease: a study of cyclin-dependent kinase inhibitor p21 in liver biopsies as a marker for progression to hepatocellular carcinoma." 05/01/2013 - "These findings correlated with decreased levels of the cyclin-dependent kinase inhibitor p21(Waf1/Cip1) and concurrent activation (phosphorylation) of PDGFRα in the hepatocellular carcinomas generated in the decorin-null vis-à-vis wild-type mice. " 10/01/2010 - "To investigate the effects of simvastatin on the proliferation, cell cycle and expression of cyclin-dependent kinase inhibitor p21 protein in human hepatocellular carcinoma (HepG2) cells in vitro. " 01/30/2004 - "We reported here that overexpression of integrin beta1 imposed a growth inhibitory effect on the hepatocellular carcinoma cell line SMMC-7721, and this phenomenon was mainly attributed to the cyclin-dependent kinase inhibitor p21(CIP1). "

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Related Therapies and Procedures

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4.	Aftercare (After-Treatment)