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Crk-Associated Substrate Protein

A highly phosphorylated 130 kDa protein that associates with ONCOGENE PROTEIN CRK and ONCOGENE PROTEIN SRC. It undergoes tyrosine PHOSPHORYLATION in signaling pathways that regulate CELL MIGRATION and CELL PROLIFERATION.
Also Known As:
BCAR1 Protein; BCAR1 p130Cas Protein; Breast Cancer Anti-Estrogen Resistance 1 Protein; CRKAS Protein; Crk-Associated Substrate; p130 Cas Protein; p130 Crk-Associated Substrate; p130Cas Protein; Breast Cancer Anti Estrogen Resistance 1 Protein; Crk Associated Substrate; Crk Associated Substrate Protein; Protein, BCAR1 p130Cas; Protein, CRKAS; p130 Crk Associated Substrate; p130Cas Protein, BCAR1
Networked: 44 relevant articles (0 outcomes, 3 trials/studies)

Bio-Agent Context: Research Results

Experts

1. Kirsch, Kathrin H: 4 articles (08/2016 - 02/2012)
2. Kumbrink, Joerg: 4 articles (08/2016 - 02/2012)
3. Honda, Hiroaki: 3 articles (04/2020 - 12/2011)
4. Brinkman, Arend: 3 articles (09/2004 - 08/2004)
5. Dorssers, Lambert C J: 3 articles (09/2004 - 08/2004)
6. Foekens, John A: 3 articles (09/2004 - 08/2004)
7. Geurts-Moespot, Anneke: 3 articles (09/2004 - 08/2004)
8. Grebenchtchikov, Nicolai: 3 articles (09/2004 - 08/2004)
9. Span, Paul N: 3 articles (09/2004 - 08/2004)
10. Brinkman, A: 3 articles (07/2001 - 01/2000)

Related Diseases

1. Colorectal Neoplasms (Colorectal Cancer)
04/18/2013 - "We show that p130 Crk-associated substrate (p130Cas) is a direct substrate of PTPN14 and that PTPN14 specifically regulates p130Cas phosphorylation at tyrosine residue 128 (Y128) in colorectal cancer (CRC) cells. "
01/01/2004 - "The purpose of the present study was to determine the effects of G17 amide on tyrosine phosphorylation of focal adhesion kinase (FAK), paxillin, and p130 Crk-associated substrate (p130(Cas)) in Colo 320 cells, a human colorectal cancer cell line which expresses CCK(2) receptors. "
12/01/2021 - ": CRC: colorectal cancer; SCFAs: short chain fatty acids; HDAC: histone deacetylase; TCA cycle: tricarboxylic acid cycle; CoA: cytosolic acyl coenzyme A; SCAD: short chain acyl CoA dehydrogenase; HDAC: histone deacetylase; MiR-92a: microRNA-92a; KLF4: kruppel-like factor; PTEN: phosphatase and tensin homolog; PI3K: phosphoinositide 3-kinase; PIP2: phosphatidylinositol 4, 5-biphosphate; PIP3: phosphatidylinositol-3,4,5-triphosphate; Akt1: protein kinase B subtype α; ERK1/2: extracellular signal-regulated kinases 1/2; EMT: epithelial-to-mesenchymal transition; NEDD9: neural precursor cell expressed developmentally down-regulated9; CAS: Crk-associated substrate; JNK: c-Jun N-terminal kinase; PRMT1: protein arginine methyltransferase 1; UDCA: ursodeoxycholic acid; BA: bile acids; CA: cholic acid; CDCA: chenodeoxycholic acid; DCA: deoxycholic acid; LCA: lithocholic acid; CSCs: cancer stem cells; MHC: major histocompatibility; NF-κB: NF-kappaB; GPR: G protein-coupled receptors; ROS: reactive oxygen species; RNS: reactive nitrogen substances; BER: base excision repair; DNA: deoxyribonucleic acid; EGFR: epidermal growth factor receptor; MAPK: mitogen activated protein kinase; ERKs: extracellular signal regulated kinases; AKT: protein kinase B; PA: phosphatidic acid; TMAO: trimethylamine n-oxide; TMA: trimethylamine; FMO3: flavin-containing monooxygenase 3; H2S: Hydrogen sulfide; SRB: sulfate-reducing bacteria; IBDs: inflammatory bowel diseases; NSAID: non-steroidal anti-inflammatory drugs; BFT: fragile bacteroides toxin; ETBF: enterotoxigenic fragile bacteroides; E-cadherin: extracellular domain of intercellular adhesive protein; CEC: colonic epithelial cells; SMOX: spermine oxidase; SMO: smoothened; Stat3: signal transducer and activator of transcription 3; Th17: T helper cell 17; IL17: interleukin 17; AA: amino acid; TCF: transcription factor; CDT: cytolethal distending toxin; PD-L1: programmed cell death 1 ligand 1."
2. Endometrioid Carcinoma
3. Prostatic Neoplasms (Prostate Cancer)
4. Breast Neoplasms (Breast Cancer)
5. Neoplasms (Cancer)

Related Drugs and Biologics

1. Paxillin
2. Tyrosine (L-Tyrosine)
3. Focal Adhesion Protein-Tyrosine Kinases
4. Amides
5. Proteins (Proteins, Gene)
6. Tamoxifen
7. Estrogen Receptor Modulators (Antiestrogen)
8. Integrins
9. Estrogens (Estrogen)
10. ErbB Receptors (EGF Receptor)

Related Therapies and Procedures

1. Therapeutics