E2F2 Transcription Factor

An E2F transcription factor that interacts directly with RETINOBLASTOMA PROTEIN and CYCLIN A. E2F2 activates GENETIC TRANSCRIPTION required for CELL CYCLE entry and DNA synthesis.

Also Known As:

E2F Transcription Factor 2 Protein; E2F-2 Protein; E2F2 Protein; Transcription Factor E2F-2; E2F-2, Transcription Factor; Transcription Factor E2F 2; Transcription Factor, E2F2

Networked: 5 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Transcription Factors: 38804
    - E2F Transcription Factors: 483
      - E2F2 Transcription Factor: 5
        Drosophila E2f2 protein
        human E2F2 protein
        mouse E2f2 protein

Experts

1.	Chen, Mo: 1 article (11/2021)
2.	Hou, Ya-Xuan: 1 article (11/2021)
3.	Kong, Wei-Jia: 1 article (11/2021)
4.	Li, Yu-Qing: 1 article (11/2021)
5.	Lu, Mei-Xia: 1 article (11/2021)
6.	Qi, Hong-Jiao: 1 article (11/2021)
7.	Tian, Ting-Ting: 1 article (11/2021)
8.	Wang, Gui-Yang: 1 article (11/2021)
9.	Xu, Wen-Mao: 1 article (11/2021)
10.	Zhou, Meng: 1 article (11/2021)

Related Diseases

1.	Neoplasms (Cancer) 10/01/2014 - "Since the encoded E2F2 transcription factor has been implicated in both tumor suppression and tumor development, we conducted a functional study to investigate the pertinence of E2F2 to human gliomagenesis. " 11/12/2021 - "In terms of mechanism, compared with rs2075993 allele T, we found that the protective variant rs2075993 allele C interfered with the translational inhibition of E2F2 by miR-940, resulting in increased expression of E2F2 protein, which further reduced the proliferation, migration, invasion, and increased the senescence of tumor cells." 12/01/2022 - "Atypical E3 ligase ZFP91 promotes small-molecule-induced E2F2 transcription factor degradation for cancer therapy."
2.	Squamous Cell Carcinoma of Head and Neck 03/28/2023 - "This study aimed to analyse the expression of the E2F2 gene and E2F2 protein and demonstrate E2F2 target microRNAs (miRNAs) candidates (miR-125b-5p, miR-155-3p, and miR-214-5p) in oral squamous cell carcinoma tumour and margin samples. "
3.	Ovarian Neoplasms (Ovarian Cancer) 01/01/2021 - "Circular RNA circE2F2 promotes malignant progression of ovarian cancer cells by upregulating the expression of E2F2 protein via binding to HuR protein."

Related Drugs and Biologics

1.	MicroRNAs (MicroRNA)
2.	Ubiquitin-Protein Ligases (Ubiquitin-Protein Ligase)
3.	Circular RNA
4.	ELAV-Like Protein 1

Related Therapies and Procedures

1.	Therapeutics