E2F7 Transcription Factor

An E2F transcription factor that represses GENETIC TRANSCRIPTION required for CELL CYCLE entry and DNA synthesis. E2F7 has two separate DNA-binding domains and binds to DNA independently of a dimerization partner.

Also Known As:

E2F Transcription Factor 7 Protein; Transcription Factor E2F-7; Transcription Factor E2F 7; Transcription Factor, E2F7

Networked: 5 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Transcription Factors: 38804
    - E2F Transcription Factors: 483
      - E2F7 Transcription Factor: 5
        human E2F7 protein
        mouse E2f7 protein

Experts

1.	Chen, Rui: 1 article (01/2018)
2.	Dong, Gaochao: 1 article (01/2018)
3.	Fang, Tian: 1 article (01/2018)
4.	Hu, Jingwen: 1 article (01/2018)
5.	Ma, Zhifei: 1 article (01/2018)
6.	Qiu, Mantang: 1 article (01/2018)
7.	Wang, Jie: 1 article (01/2018)
8.	Wang, Jun: 1 article (01/2018)
9.	Wang, Siwei: 1 article (01/2018)
10.	Xia, Wenjia: 1 article (01/2018)

Related Diseases

1.	Neoplasms (Cancer) 08/19/2022 - "The E2F7 transcription factor has been confirmed to be related to the occurrence and development of a variety of solid tumors, but the relationship with the prognosis of lung cancer is still unclear. " 01/01/2018 - "circPRKCI functioned as a sponge for both miR-545 and miR-589 and abrogated their suppression of the protumorigenic transcription factor E2F7 Intratumor injection of cholesterol-conjugated siRNA specifically targeting circPRKCI inhibited tumor growth in a patient-derived lung adenocarcinoma xenograft model. "
2.	Triple Negative Breast Neoplasms 01/01/2023 - "Natural compound So-2 suppresses triple-negative breast cancer through inducing ferroptosis via downregulating transcription factor E2F7."
3.	Melanoma (Melanoma, Malignant) 01/01/2023 - "The miR-30a-5p loaded rMMNs nanodrug (miR-30a-5p@rMMNs) upregulated miR-30a-5p level and inhibited malignant phenotypes of ocular melanoma by targeting the transcription factor E2F7 both in vitro and in vivo. "
4.	Lung Neoplasms (Lung Cancer) 08/19/2022 - "The E2F7 transcription factor has been confirmed to be related to the occurrence and development of a variety of solid tumors, but the relationship with the prognosis of lung cancer is still unclear. "
5.	Uterine Cervical Neoplasms (Cancer of the Cervix) 10/01/2023 - "CISD2 transcriptional activated by transcription factor E2F7 promotes the malignant progression of cervical cancer."

Related Drugs and Biologics

1.	Small Interfering RNA (siRNA)
2.	Cholesterol