E2F5 Transcription Factor

An E2F transcription factor that represses GENETIC TRANSCRIPTION required for CELL CYCLE entry and DNA synthesis. E2F5 recruits chromatin remodeling factors indirectly to target gene promoters through RETINOBLASTOMA LIKE PROTEIN P130.

Also Known As:

Networked: 5 relevant articles (1 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Al-Moundhri, Mansour S: 1 article (07/2017)
2.	Burney, Ikram: 1 article (07/2017)
3.	Gupta, Ishita: 1 article (07/2017)
4.	Tamimi, Yahya: 1 article (07/2017)
5.	Grützmann, Robert: 1 article (03/2010)
6.	Joensson, Peer: 1 article (03/2010)
7.	Pilarsky, Christian: 1 article (03/2010)
8.	Rückert, Felix: 1 article (03/2010)
9.	Saeger, Hans-Detlev: 1 article (03/2010)
10.	Bajic, Vladimir B: 1 article (02/2010)

Related Diseases

1.	Pancreatic Neoplasms (Pancreatic Cancer) 03/01/2010 - "Our results suggest that the improved response toward chemotherapy in LOLX2-silenced pancreatic cancer cells is possibly mediated by the transcription factor E2F5."
2.	Neoplasms (Cancer) 02/24/2010 - "Using a combination of computational (selection of candidate TF markers and malignancy prediction) and experimental approaches (tissue microarray and western blotting on patient samples) we identified and evaluated E2F5 transcription factor involved in cell proliferation, as a promising candidate regulatory target in early stage disease. " 03/25/2008 - "The retinoblastoma (Rb) gene family member p130 binds preferentially to the E2F5 transcription factor and forms a repressive E2F5/p130 complex that inhibits cell cycle progression and tumor growth. " 03/10/2009 - "Quantitative reverse transcriptase PCR detected overexpression of a cell cycle-related transcription factor, E2F-5, in ER-negative breast cancers, and fluorescence in situ hybridisation detected gene amplification of E2F-5 in 5 out of 57 (8.8%) breast cancer samples. "
3.	Retinoblastoma (Glioblastoma, Retinal) 03/25/2008 - "The retinoblastoma (Rb) gene family member p130 binds preferentially to the E2F5 transcription factor and forms a repressive E2F5/p130 complex that inhibits cell cycle progression and tumor growth. "
4.	Ovarian Neoplasms (Ovarian Cancer) 07/01/2017 - "Similarly, ChIP analysis revealed that relevant candidate genes were regulated by the E2F5 transcription factor in ovarian cancer tissue. "
5.	Breast Neoplasms (Breast Cancer) 03/10/2009 - "In conclusion, we identify, for the first time, a population of breast cancer cells that overexpress the cell cycle-related transcription factor, E2F-5. " 03/10/2009 - "Quantitative reverse transcriptase PCR detected overexpression of a cell cycle-related transcription factor, E2F-5, in ER-negative breast cancers, and fluorescence in situ hybridisation detected gene amplification of E2F-5 in 5 out of 57 (8.8%) breast cancer samples. "

Related Drugs and Biologics

1.	RNA-Directed DNA Polymerase (Reverse Transcriptase)

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)