Sodium-Phosphate Cotransporter Proteins (Sodium-Phosphate Cotransporter)

A family of symporters that facilitate sodium-dependent membrane transport of phosphate.

Also Known As:

Sodium-Phosphate Cotransporter; Sodium Phosphate Transporter; Sodium Phosphate Transporters; Sodium-Phosphate Symporters; Cotransporter Proteins, Sodium-Phosphate; Phosphate Transporter, Sodium; Phosphate Transporters, Sodium; Sodium Phosphate Cotransporter; Sodium Phosphate Cotransporter Proteins; Sodium Phosphate Symporters; Symporters, Sodium-Phosphate; Transporters, Sodium Phosphate

Networked: 60 relevant articles (2 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Carrier Proteins: 12999
    - Membrane Transport Proteins: 589
      - Ion Pumps: 61
        Symporters: 1442
        Sodium-Phosphate Cotransporter Proteins: 60
        E coli YjbB protein
        Type I Sodium-Phosphate Cotransporter Proteins
        Type II Sodium-Phosphate Cotransporter Proteins
        Type III Sodium-Phosphate Cotransporter Proteins
        Anion Transport Proteins: 2
        Phosphate Transport Proteins: 147
        Sodium-Phosphate Cotransporter Proteins: 60
        E coli YjbB protein
        Type I Sodium-Phosphate Cotransporter Proteins
        Type II Sodium-Phosphate Cotransporter Proteins
        Type III Sodium-Phosphate Cotransporter Proteins
    - Phosphate-Binding Proteins: 14
      - Phosphate Transport Proteins: 147
        Sodium-Phosphate Cotransporter Proteins: 60
        E coli YjbB protein
        Type I Sodium-Phosphate Cotransporter Proteins
        Type II Sodium-Phosphate Cotransporter Proteins
        Type III Sodium-Phosphate Cotransporter Proteins
  - Membrane Proteins: 10078
    - Membrane Transport Proteins: 589
      - Ion Pumps: 61
        Symporters: 1442
        Sodium-Phosphate Cotransporter Proteins: 60
        E coli YjbB protein
        Type I Sodium-Phosphate Cotransporter Proteins
        Type II Sodium-Phosphate Cotransporter Proteins
        Type III Sodium-Phosphate Cotransporter Proteins
        Anion Transport Proteins: 2
        Phosphate Transport Proteins: 147
        Sodium-Phosphate Cotransporter Proteins: 60
        E coli YjbB protein
        Type I Sodium-Phosphate Cotransporter Proteins
        Type II Sodium-Phosphate Cotransporter Proteins
        Type III Sodium-Phosphate Cotransporter Proteins

Experts

1.	Konrad, Martin: 2 articles (08/2020 - 02/2016)
2.	Schlingmann, Karl P: 2 articles (08/2020 - 02/2016)
3.	Levine, Michael A: 2 articles (01/2020 - 11/2009)
4.	Molin, Arnaud: 2 articles (01/2019 - 10/2018)
5.	Hernando, Nati: 2 articles (01/2018 - 02/2016)
6.	Wagner, Carsten A: 2 articles (01/2018 - 02/2016)
7.	Khan, Saeed R: 2 articles (09/2011 - 05/2008)
8.	Bergwitz, Clemens: 2 articles (10/2008 - 02/2006)
9.	Demer, Linda L: 2 articles (09/2008 - 07/2002)
10.	Tintut, Yin: 2 articles (09/2008 - 07/2002)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2021 - "SLC34A2/NaPi2b is a sodium phosphate transporter expressed in a variety of human tumors including lung and ovarian carcinoma, as well as the normal tissues from which these tumors arise. " 11/15/2015 - "Here, we have appended monomethyl auristatin E (MMAE) to an antibody recognizing the SLC34A2 gene product NaPi2b, the type II sodium-phosphate cotransporter, which is highly expressed on tumor surfaces of the lung, ovary, and thyroid as well as on normal lung pneumocytes. " 11/01/2016 - "These include the Fanconi syndrome, various genetic mutations of fibroblast growth factor 23 (FGF23) handling and the sodium/phosphate cotransporter, and those due to FGF23 secretion by mesenchymal tumors. " 01/01/2013 - "Rebmab200, a humanized monoclonal antibody targeting the sodium phosphate transporter NaPi2b displays strong immune mediated cytotoxicity against cancer: a novel reagent for targeted antibody therapy of cancer." 01/01/2022 - "The widely expressed mammalian sodium/phosphate cotransporter SLC20A1/PiT1 mediates phosphate uptake into most cell types; however, while SLC20A1 is required for development, and elevated SLC20A1 expression is associated with vascular calcification and aggressive tumor growth, the mechanisms regulating SLC20A1 protein abundance are unknown. "
2.	Hypophosphatemic Rickets 02/06/2004 - "FGF-23 transgenic mice demonstrate hypophosphatemic rickets with reduced expression of sodium phosphate cotransporter type IIa." 11/01/2009 - "Hypophosphatemic rickets with hypercalciuria due to mutation in SLC34A3/type IIc sodium-phosphate cotransporter: presentation as hypercalciuria and nephrolithiasis." 08/01/2007 - "Original reports published in 2006/2007 bring valuable pieces of information that enable better understanding of the physiological regulation of phosphate homeostasis by more precisely defining the interplay between PHEX, vitamin D, and phosphatonins; identification of new genes causing hypophosphatemic rickets, aside from PHEX and fgf23, namely the genes encoding for a renal sodium-phosphate cotransporter, NaPiIIc, and for a bone matrix protein, DmpI; and improved diagnosis of tumor-induced osteomalacia with more precise imaging techniques for tumor localization and more precise fibroblast growth factor 23 assays. "
3.	Acute Kidney Injury (Acute Renal Failure) 04/23/2010 - "We created transgenic (TG) mice with kidney-specific overexpression of Sirt1 using the promoter sodium-phosphate cotransporter IIa (Npt2) driven specifically in proximal tubules and investigated the kidney-specific role of Sirt1 in the protection against acute kidney injury (AKI). "
4.	Oncogenic osteomalacia 08/01/2007 - "Original reports published in 2006/2007 bring valuable pieces of information that enable better understanding of the physiological regulation of phosphate homeostasis by more precisely defining the interplay between PHEX, vitamin D, and phosphatonins; identification of new genes causing hypophosphatemic rickets, aside from PHEX and fgf23, namely the genes encoding for a renal sodium-phosphate cotransporter, NaPiIIc, and for a bone matrix protein, DmpI; and improved diagnosis of tumor-induced osteomalacia with more precise imaging techniques for tumor localization and more precise fibroblast growth factor 23 assays. "
5.	Hyperphosphatemia 01/01/2022 - "Targeting sodium phosphate cotransporter 2a (Npt2a) offers a novel strategy for treating hyperphosphatemia in chronic kidney disease (CKD). " 11/01/2019 - "The sodium-phosphate cotransporter Npt2a, which mediates a large proportion of phosphate reabsorption in the kidney, might be a good therapeutic target for new medications for hyperphosphatemia. " 11/01/2018 - "Collectively, mice with a deletion of PTH1R alone in proximal tubules results in only minor changes in phosphate regulation, whereas deletion of both PTH1R and Klotho leads to a severe disturbance, including hyperphosphatemia with increased sodium/phosphate cotransporter expression in BBM. " 11/01/2009 - "Hyperphosphatemia in Hyp/klotho(-/-) mice was associated with increased renal expression of sodium/phosphate cotransporter 2a (NaPi2a) protein. " 11/01/2007 - "Correlation among hyperphosphatemia, type II sodium phosphate transporter activity, and vitamin D metabolism in Fgf-23 null mice."

Related Drugs and Biologics

1.	Phosphates (Orthophosphate)
2.	Proteins (Proteins, Gene)
3.	Fibroblast Growth Factor-23
4.	Vitamin D
5.	Sirtuin 1
6.	dimyristoylphosphatidylinositol
7.	Vitamin D3 24-Hydroxylase
8.	Organic Anion Transporters
9.	Peptides (Polypeptides)
10.	Parathyroid Hormone (Parathormone)

Related Therapies and Procedures

1.	Therapeutics
2.	Denervation