Squalene Monooxygenase (Squalene Epoxidase)

The second enzyme in the committed pathway for CHOLESTEROL biosynthesis, this enzyme catalyzes the first oxygenation step in the biosynthesis of STEROLS and is thought to be a rate limiting enzyme in this pathway. Specifically, this enzyme catalyzes the conversion of SQUALENE to (S)-squalene-2,3-epoxide.

Also Known As:

Networked: 79 relevant articles (3 outcomes, 2 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Li, Chuangen: 3 articles (11/2022 - 01/2018)
2.	Liu, Dabin: 3 articles (11/2022 - 01/2018)
3.	Wong, Chi Chun: 3 articles (11/2022 - 01/2018)
4.	Yu, Jun: 3 articles (11/2022 - 01/2018)
5.	Zhou, Yunfei: 3 articles (11/2022 - 01/2018)
6.	Brown, Andrew J: 3 articles (01/2021 - 01/2019)
7.	Ballestrero, Alberto: 3 articles (11/2020 - 01/2016)
8.	Zoppoli, Gabriele: 3 articles (11/2020 - 01/2016)
9.	Chen, Ying: 2 articles (03/2022 - 01/2019)
10.	He, Luwei: 2 articles (03/2022 - 01/2021)

Related Diseases

1.	Tinea (Ringworm) 10/01/2023 - "The gold standard treatment for dermatophytosis is the squalene epoxidase (SQLE) inhibitor terbinafine. " 10/01/2021 - "In refractory and recurrent dermatophytoses, terbinafine resistance should be considered, especially in T. mentagrophytes and T. rubrum, and in vitro resistance testing of the dermatophyte and point mutation analysis of squalene epoxidase (SQLE) should be performed. " 01/01/2021 - "Checkerboard Analysis To Evaluate Synergistic Combinations of Existing Antifungal Drugs and Propylene Glycol Monocaprylate in Isolates from Recalcitrant Tinea Corporis and Cruris Patients Harboring Squalene Epoxidase Gene Mutation." 12/01/2018 - "Correlation of In Vitro Susceptibility Based on MICs and Squalene Epoxidase Mutations with Clinical Response to Terbinafine in Patients with Tinea Corporis/Cruris." 01/01/2022 - "Extensive dermatophytosis caused by terbinafine-resistant Trichophyton indotineae harboring Phe397Leu and Leu393Ser substitutions in the squalene epoxidase enzyme was diagnosed in France. "
2.	Hypercholesterolemia 12/01/2011 - "Research on new squalene monooxygenase inhibitors is important due to the prevalence of hypercholesterolemia and the lack of both sufficient and safe remedies. " 07/15/1991 - "From these observations, squalene epoxidase inhibitor is expected to be highly effective in the treatment of hypercholesterolemia and also is very useful as a research tool for studying the regulation of cholesterol metabolism." 12/01/2011 - "In this paper we (i) review data on activity and the structure of squalene monooxygenase, (ii) present its inhibitors, (iii) compare current strategies of lowering cholesterol level in blood with some of the most promising strategies, (iv) underline advantages of squalene monooxygenase as a target for hypercholesterolemia therapy, and (v) discuss safety concerns about hypercholesterolemia therapy based on inhibition of cellular cholesterol biosynthesis and potential usage of squalene monooxygenase inhibitors in clinical practice. " 12/01/2011 - "Squalene monooxygenase downregulation in vertebrates and fungi decreases synthesis of cholesterol and ergosterol, respectively, which makes squalene monooxygenase a potent and attractive target of hypercholesterolemia and antifungal therapies. "
3.	Infections 01/01/2022 - "Terbinafine therapy is usually effective in eradicating infections due to these species by inhibiting their squalene epoxidase (SQLE) enzyme, but increasing numbers of clinically resistant cases and mutations in the SQLE gene have been documented recently. "
4.	Neoplasms (Cancer) 10/14/2023 - "Squalene epoxidase (SQLE) is a crucial regulator of ferroptosis and has been associated with promoting cell growth and invasion in different types of human cancers. " 01/01/2023 - "Drugs that block squalene monooxygenase activity have been shown to stop cancer cells from growing, but unfortunately these drugs are also toxic to mammals. " 01/01/2022 - "Recently, increasing attention has been paid to the role of Squalene epoxidase (SQLE) in several types of cancers. " 01/01/2022 - "Accumulating evidence suggests that squalene epoxidase (SQLE) plays a pivotal role in the development and progression of several cancer types in humans. " 01/01/2019 - "The shape of human squalene epoxidase expands the arsenal against cancer."
5.	Alopecia (Baldness) 04/01/2021 - "This study analyzes Trichophyton cacao compounds as anti-alopecia by inhibiting the squalene epoxidase enzyme formation, in silico. "

Related Drugs and Biologics

1.	Terbinafine (Lamisil)
2.	Enzymes
3.	Cholesterol
4.	Squalene
5.	Tellurium
6.	Messenger RNA (mRNA)
7.	Proteins (Proteins, Gene)
8.	Ergosterol (Lumisterol)
9.	Allylamine
10.	Squalene Monooxygenase (Squalene Epoxidase)

Related Therapies and Procedures

1.	Therapeutics
2.	Radiotherapy
3.	Castration