Vesicular Glutamate Transport Protein 2

A vesicular glutamate transporter protein that is predominately expressed in the DIENCEPHALON and lower brainstem regions of the CENTRAL NERVOUS SYSTEM.

Also Known As:

DNPI Protein; Differentiation-Associated Na-Dependent Inorganic Phosphate Cotransporter; VGLUT2 Protein; Differentiation Associated Na Dependent Inorganic Phosphate Cotransporter; Vesicular Glutamate Transporter 2

Networked: 25 relevant articles (1 outcomes, 4 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Carrier Proteins: 12999
    - Membrane Transport Proteins: 589
      - Ion Pumps: 61
        Antiporters: 369
        Vesicular Neurotransmitter Transport Proteins: 3
        Vesicular Glutamate Transport Proteins: 77
        Vesicular Glutamate Transport Protein 2: 25
        human SLC17A6 protein
        mouse Slc17a6 protein
        rat Slc17a6 protein
      - Neurotransmitter Transport Proteins: 24
        Vesicular Neurotransmitter Transport Proteins: 3
        Vesicular Glutamate Transport Proteins: 77
        Vesicular Glutamate Transport Protein 2: 25
        human SLC17A6 protein
        mouse Slc17a6 protein
        rat Slc17a6 protein
  - Membrane Proteins: 10078
    - Membrane Transport Proteins: 589
      - Ion Pumps: 61
        Antiporters: 369
        Vesicular Neurotransmitter Transport Proteins: 3
        Vesicular Glutamate Transport Proteins: 77
        Vesicular Glutamate Transport Protein 2: 25
        human SLC17A6 protein
        mouse Slc17a6 protein
        rat Slc17a6 protein
      - Neurotransmitter Transport Proteins: 24
        Vesicular Neurotransmitter Transport Proteins: 3
        Vesicular Glutamate Transport Proteins: 77
        Vesicular Glutamate Transport Protein 2: 25
        human SLC17A6 protein
        mouse Slc17a6 protein
        rat Slc17a6 protein

Experts

1.	Wallén-Mackenzie, Åsa: 3 articles (01/2018 - 04/2011)
2.	Kullander, Klas: 3 articles (10/2014 - 04/2011)
3.	Lagerström, Malin C: 3 articles (10/2014 - 04/2011)
4.	Rogoz, Katarzyna: 3 articles (10/2014 - 04/2011)
5.	Chen, Lixue: 1 article (11/2020)
6.	Niu, Yingying: 1 article (11/2020)
7.	Qin, Guangcheng: 1 article (11/2020)
8.	Zeng, Xiaoxu: 1 article (11/2020)
9.	Zhang, Dunke: 1 article (11/2020)
10.	Zhou, Jiying: 1 article (11/2020)

Related Diseases

1.	Substance Withdrawal Syndrome (Withdrawal Symptoms) 10/01/2020 - "We found that conditional deletion of MORs from glutamatergic neurons expressing vesicular glutamate transporter 2 (Vglut2+) largely eliminated the naloxone-precipitated withdrawal symptoms. "
2.	Ganglion Cysts (Ganglion) 07/01/2015 - "A previous study found vesicular glutamate transporter 2 (vGluT2) mRNA in the pigeon retina, suggesting that bipolar and ganglion cells are glutamatergic. "
3.	Panic Disorder (Panic Attack) 05/01/2010 - "Using whole-cell patch-clamp preparations, we also show that bath applications of NaLac (positive control), but not lactic acid (lactate stimulus) or D-mannitol (osmolar stimulus), increases the firing rates of neurons in the A3Vr, which are retrogradely labeled from the DMH/PeF and which are most likely glutamatergic based on a separate study using retrograde tracing from the DMH/PeF in combination with in situ hybridization for vesicular glutamate transporter 2. These data show that hypertonic sodium, but not hyper-osmolarity or changes in lactate, is the key stimulus that provokes panic attacks in panic disorder, and is consistent with human studies."
4.	Body Weight (Weight, Body) 01/01/2019 - "In this study, the body weight, glutamate content, and expression of vesicular glutamate transporter 2 (VGLUT2) and metabotropic glutamate receptors mGluR2 and mGluR3 was examined in the striatum of offspring following treatment of the dams with As (10 or 100 mg/L NaAsO2 in drinking water). "
5.	Painful Neuropathy 10/01/2020 - "Given the significance of spinal cord glutamate transporters in neuronal plasticity and central sensitization, this study investigated the role of excitatory amino acid transporter 2 (EAAT2) and vesicular-glutamate transporter 2 (VGLUT2) in the development of paclitaxel-induced painful neuropathy. "

Related Drugs and Biologics

1.	Naloxone (Narcan)
2.	Glutamic Acid (Glutamate)
3.	Messenger RNA (mRNA)
4.	Drinking Water
5.	Excitatory Amino Acid Transporter 2
6.	Lactic Acid (Lactate)
7.	Metabotropic Glutamate Receptors (Metabotropic Glutamate Receptor)
8.	Paclitaxel (Taxol)
9.	Sodium
10.	Mannitol (Osmitrol)