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Vesicular Glutamate Transport Protein 1

Subscribe to New Research on Vesicular Glutamate Transport Protein 1

A vesicular glutamate transporter protein that is predominately expressed in TELENCEPHALON of the BRAIN.

Also Known As:

BNPI Protein; Brain-Specific Na-Dependent Inorganic Phosphate Cotransporter; VGLUT1 Protein; Brain Specific Na Dependent Inorganic Phosphate Cotransporter; Vesicular Glutamate Transporter 1

Networked: 18 relevant articles (0 outcomes, 6 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins
- Proteins: 90489
  - Carrier Proteins: 11456
    - Membrane Transport Proteins: 165
      - Ion Pumps: 30
        Antiporters: 21
        Vesicular Neurotransmitter Transport Proteins: 2
        Vesicular Glutamate Transport Proteins: 17
        Vesicular Glutamate Transport Protein 1: 18
        human SLC17A7 protein
        mouse Slc17a7 protein
        rat Slc17a7 protein
        Xenopus VGlut1 protein
      - Neurotransmitter Transport Proteins: 16
        Vesicular Neurotransmitter Transport Proteins: 2
        Vesicular Glutamate Transport Proteins: 17
        Vesicular Glutamate Transport Protein 1: 18
        human SLC17A7 protein
        mouse Slc17a7 protein
        rat Slc17a7 protein
        Xenopus VGlut1 protein
  - Membrane Proteins: 5300
    - Membrane Transport Proteins: 165
      - Ion Pumps: 30
        Antiporters: 21
        Vesicular Neurotransmitter Transport Proteins: 2
        Vesicular Glutamate Transport Proteins: 17
        Vesicular Glutamate Transport Protein 1: 18
        human SLC17A7 protein
        mouse Slc17a7 protein
        rat Slc17a7 protein
        Xenopus VGlut1 protein
      - Neurotransmitter Transport Proteins: 16
        Vesicular Neurotransmitter Transport Proteins: 2
        Vesicular Glutamate Transport Proteins: 17
        Vesicular Glutamate Transport Protein 1: 18
        human SLC17A7 protein
        mouse Slc17a7 protein
        rat Slc17a7 protein
        Xenopus VGlut1 protein

Experts

1.	McCullumsmith, Robert E: 2 articles (03/2013 - 04/2008)
2.	Haroutunian, Vahram: 2 articles (03/2013 - 04/2008)
3.	Meador-Woodruff, James H: 2 articles (03/2013 - 04/2008)
4.	Reynolds, G P: 2 articles (04/2007 - 01/2007)
5.	Harte, M K: 2 articles (04/2007 - 01/2007)
6.	Kim, Y S: 1 article (09/2015)
7.	Kim, T H: 1 article (09/2015)
8.	McKemy, D D: 1 article (09/2015)
9.	Bae, Y C: 1 article (09/2015)
10.	Robinson, John L: 1 article (09/2014)

Related Diseases

1.	Schizophrenia (Dementia Praecox) 12/01/2009 - "Resequencing and association study of vesicular glutamate transporter 1 gene (VGLUT1) with schizophrenia." 04/15/2008 - "We found increased VGLUT1 transcript and reduced VGLUT1 protein expression in the ACC, but not DLPFC, in schizophrenia. " 04/01/2007 - "Deficits in the VGluT1 (vesicular glutamate transporter-1) in both striatal and hippocampal regions support this observation, and the association of VGluT1 density with a genetic risk factor for schizophrenia points to genetic influences on these glutamatergic deficits. " 06/01/2010 - "Vesicular glutamate transporter 1, netrin-G2, and netrin-G1d and G1f were increased in bipolar disorder but not in schizophrenia. " 01/01/2014 - "This study utilized novel lentiviral short hairpin RNA (shRNA) vectors to target expression of the vesicular glutamate transporter 1 (VGLUT1) following injection into the dorsal hippocampus of adult mice, as partial reductions in VGLUT1 expression should attenuate glutamatergic signaling and similar reductions have been reported in schizophrenia. "
2.	Dementia (Dementias) 09/01/2014 - "Relative immunohistochemistry intensity measures were obtained for synaptophysin, Synaptic vesicle transporter Sv2 (now known as SV2A) and Vesicular glutamate transporter 1 in the outer molecular layer of the hippocampal dentate gyrus on the first 157 participants of 'The 90+ Study' who came to autopsy, including participants with dementia (n = 84), those with cognitive impairment but no dementia (n = 37) and those with normal cognition (n = 36). " 11/16/2010 - "We used homogenates prepared from gray matter from 2 neocortical regions (Brodmann area [BA] 9 and BA 20) and Western blotting to determine the concentrations of key components of the glutamatergic neurotransmitter system, vesicular glutamate transporter 1 (VGLUT1) and excitatory amino acid transporter EAAT2 (GLT-1), and the ubiquitous synaptic protein, synaptophysin, in 73 individuals-48 patients with cerebrovascular disease with and without dementia, 10 patients with AD, and 15 controls-in a case-control design. "
3.	Parkinsonian Disorders (Parkinsonism) 04/01/2011 - "Knowing that striatal glutamatergic afferents target dendritic spines, these data appear difficult to reconcile with evidence for an increased expression of the vesicular glutamate transporter 1 (vGluT1) in the striatum of PD patients and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-treated monkeys, as well as in some electrophysiological studies showing overactivity of the corticostriatal glutamatergic system in models of parkinsonism. "
4.	Ischemia 09/22/2008 - "In the current study, this phenomenon was not associated with diet- and or ischemia-related alterations of vesicular glutamate transporter 1 expression in various hippocampal regions although lower vesicular GABA transporter immunostaining was present in the CA1 stratum oriens and the CA3 stratum radiatum in FR sham and ischemic rats."
5.	Temporal Lobe Epilepsy 07/01/2009 - "Hippocampal distribution of vesicular glutamate transporter 1 in patients with temporal lobe epilepsy." 07/20/2007 - "The reorganizations of the overall intrinsic glutamatergic and gamma-aminobutyric acid (GABA)-ergic hippocampal networks as well as the time course of these reorganizations during development of pilocarpine-induced temporal lobe epilepsy were studied with in situ hybridization and immunohistochemistry experiments for the vesicular glutamate transporter 1 (VGLUT1) and the vesicular GABA transporter (VGAT). "

Related Drugs and Biologics

1.	Synaptophysin
2.	vesicular GABA transporter
3.	Excitatory Amino Acid Transporter 3
4.	Small Interfering RNA (siRNA)
5.	1- Methyl- 4- phenyl- 1,2,3,6- tetrahydropyridine (MPTP)
6.	salicylhydroxamic acid (SHAM)
7.	gamma-Aminobutyric Acid (GABA)
8.	Excitatory Amino Acid Transporter 1 (Glutamate Aspartate Transporter 1)
9.	Excitatory Amino Acids
10.	Glutamic Acid (Glutamate)