Inositol Oxygenase

A non-heme IRON enzyme that catalyzes the conversion of MYOINOSITOL to D-glucuronic acid. The reaction is the first committed step in MYOINOSITOL catabolic pathway. This enzyme was formerly characterized as EC 1.13.1.11 and 1.99.2.6.

Also Known As:

Networked: 25 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Kanwar, Yashpal S: 11 articles (01/2022 - 06/2010)
2.	Sharma, Isha: 5 articles (01/2022 - 01/2018)
3.	Sun, Lin: 5 articles (06/2019 - 06/2010)
4.	Xie, Ping: 4 articles (06/2019 - 06/2010)
5.	Deng, Fei: 3 articles (01/2022 - 11/2019)
6.	Dutta, Rajesh K: 3 articles (06/2019 - 01/2016)
7.	Zheng, Xiaoping: 2 articles (01/2022 - 01/2022)
8.	Gunay, Murat: 2 articles (05/2018 - 01/2018)
9.	Mertoglu, Cuma: 2 articles (05/2018 - 01/2018)
10.	Candar, Tuba: 1 article (08/2022)

Related Diseases

1.	Acute Kidney Injury (Acute Renal Failure) 05/01/2023 - "In our study, kidney injury molecule-1 (KIM-1) and myo-inositol oxygenase (MIOX) were used to compare acute kidney injury in patients that underwent PNL and RIRS. " 01/01/2020 - "Effectiveness of myo-inositol oxygenase in the early diagnosis of experimental acute kidney injury." 01/01/2018 - "Myo-inositol Oxygenase as a Novel Marker in the Diagnosis of Acute Kidney Injury." 01/01/2022 - "Serum myo-inositol oxygenase levels at hospital discharge predict progression to chronic kidney disease in community-acquired acute kidney injury." 01/01/2020 - "The effectiveness of the myo-inositol oxygenase (MIOX) enzyme was investigated in the diagnosis of acute kidney injury (AKI). "
2.	Diabetic Nephropathies (Diabetic Nephropathy) 01/01/2018 - "Contribution of myo-inositol oxygenase in AGE:RAGE-mediated renal tubulointerstitial injury in the context of diabetic nephropathy." 06/01/2015 - "Disruption of renal tubular mitochondrial quality control by Myo-inositol oxygenase in diabetic kidney disease." 06/01/2009 - "Increased expression of myo-inositol oxygenase is involved in the tubulointerstitial injury of diabetic nephropathy." 06/01/2010 - "Pathobiology of renal-specific oxidoreductase/myo-inositol oxygenase in diabetic nephropathy: its implications in tubulointerstitial fibrosis." 06/28/2019 - "Withdrawal: myo-Inositol oxygenase overexpression accentuates generation of reactive oxygen species and exacerbates cellular injury following high glucose ambience: A new mechanism relevant to the pathogenesis of diabetic nephropathy."
3.	Obesity 07/16/2020 - "Myo-inositol oxygenase (MIOX), a tubular enzyme, alters redox balance and subsequent tubular injury in the settings of obesity. " 01/15/2016 - "Transcriptional and Translational Modulation of myo-Inositol Oxygenase (Miox) by Fatty Acids: IMPLICATIONS IN RENAL TUBULAR INJURY INDUCED IN OBESITY AND DIABETES."
4.	Chronic Renal Insufficiency 01/01/2022 - "Serum myo-inositol oxygenase levels at hospital discharge predict progression to chronic kidney disease in community-acquired acute kidney injury."
5.	Diabetes Complications 01/20/2006 - "Expression of myo-inositol oxygenase in tissues susceptible to diabetic complications."

Related Drugs and Biologics

1.	Enzymes
2.	Biomarkers (Surrogate Marker)
3.	Reactive Oxygen Species (Oxygen Radicals)
4.	Proteins (Proteins, Gene)
5.	Oxidoreductases (Dehydrogenase)
6.	Inositol (Myoinositol)
7.	Glucose (Dextrose)
8.	Inflammasomes
9.	Hydroxyeicosatetraenoic Acids (HETE)
10.	Gentamicins (Gentamicin)