3-Hydroxyanthranilate 3,4-Dioxygenase (3 Hydroxyanthranilate 3,4 Dioxygenase)

An enzyme that catalyzes the conversion of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde. It was formerly characterized as EC 1.13.1.6.

Also Known As:

3 Hydroxyanthranilate 3,4 Dioxygenase; 3-HAA Oxygenase; 3-Hydroxyanthranilic Acid Oxygenase; 3 HAA Oxygenase; 3 Hydroxyanthranilic Acid Oxygenase; 3,4-Dioxygenase, 3-Hydroxyanthranilate; Acid Oxygenase, 3-Hydroxyanthranilic; Oxygenase, 3-HAA; Oxygenase, 3-Hydroxyanthranilic Acid

Networked: 8 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Oxidoreductases: 13671
    - Oxygenases: 333
      - Dioxygenases: 495
        3-Hydroxyanthranilate 3,4-Dioxygenase: 8
        S cerevisiae BNA1 protein

Experts

1.	Karlsson, Håkan: 1 article (01/2017)
2.	Li, Fang: 1 article (01/2017)
3.	Seifert, Josef: 1 article (11/2014)

Related Diseases

1.	Epilepsy (Aura) 07/15/1998 - "Increased expression of 3-hydroxyanthranilate 3,4-dioxygenase gene in brain of epilepsy-prone El mice." 02/14/1992 - "Abnormally high activity of 3-hydroxyanthranilate 3,4-dioxygenase in brain of epilepsy-prone El mice." 11/01/1995 - "We had shown that production of quinolinic acid is high in the brain of epilepsy-prone El mice and that this is due to an increase in the activity of 3-hydroxyanthranilate 3,4-dioxygenase (3-HAO, EC 1.13.11.6). " 11/01/1995 - "Increase in the level of mRNA for 3-hydroxyanthranilate 3,4-dioxygenase in brain of epilepsy-prone El mice." 08/13/1993 - "We have shown previously that the activity of 3-hydroxyanthranilate 3,4-dioxygenase, a QUIN-synthesizing enzyme, was abnormally high in the brains of epilepsy-prone E1 mice as compared with that of ddY mice. "
2.	Gliosis 01/01/1993 - "Analogous experiments with liver slices showed that > 93% of newly synthesized QUIN had entered the extracellular compartment within 30 min. Striatal and nigral slices obtained 7 days after an intrastriatal ibotenic acid injection showed severalfold increases in QUIN production compared with control tissues, in all likelihood due to astrogliosis and associated large increases in 3-hydroxyanthranilic acid oxygenase activity. " 03/29/1996 - "Excitotoxic lesions of the adult rat striatum result in reactive gliosis and an associated increase in the activities of the astrocytic enzymes 3-hydroxyanthranilic acid oxygenase (3HAO) and kynurenine aminotransferase (KAT), which are responsible for the biosynthesis of the neurotoxin quinolinic acid and the neuroprotectant kynurenic acid, respectively. "
3.	Infections 01/01/2017 - "Inhibition of IDO during the infection also resulted in reduction of virus-driven upregulation of 3-hydroxyanthranilate 3,4-dioxygenase (HAAO), but not kynurenine 3-monooxygenase (KMO), which are enzymes downstream in the kynurenine pathway. "
4.	Hyperglycemia 11/01/2014 - "In mouse livers, the altered levels of several enzymes of glucose metabolism were considered with regards to amelioration of hyperglycemia due to diazinon; the reduced levels of 3-hydroxyanthranilate 3,4-dioxygenase to the changes in the l-tryptophan to NAD metabolism caused by pyrimidinyl and crotonamide OPI; the reduced levels of catalase, peroxiredoxin and superoxide dismutase to OPI-increased lipid and/or kynurenine oxidation, the latter effect resulting also in increased urinary excretion of xanthurenic and kynurenic acids; and an increase in glutathione S-methyltransferase to OPI detoxification. "

Related Drugs and Biologics

1.	Enzymes
2.	Quinolinic Acid
3.	Neurotoxins
4.	Kynurenine
5.	Peroxiredoxins
6.	Kynurenine 3-Monooxygenase (Kynurenine 3 Monooxygenase)
7.	Neuroprotective Agents
8.	Tryptophan (L-Tryptophan)
9.	Superoxide Dismutase
10.	Messenger RNA (mRNA)